Differentiation pathways in primary invasive breast carcinoma as suggested by intermediate filament and biopathological marker expression

Journal of Pathology

Volumn 179, Issue 4, 1996, Pages 386-391

  Santini, Donatella ^a,b   Ceccarelli, Claudio ^a   Taffurelli, Mario ^a   Pileri, Stefano ^a   Marrano, Domenico ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Breast cancer; Epidermal growth factor rceptor; Immunohistochemistry; Intermediate filaments

Indexed keywords

ACTIN; CYTOKERATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; INTERMEDIATE FILAMENT PROTEIN; MONOCLONAL ANTIBODY KI 67; PROGESTERONE RECEPTOR; VIMENTIN;

ARTICLE; BREAST CARCINOMA; CANCER GROWTH; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL DIFFERENTIATION; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; INTERMEDIATE FILAMENT PROTEINS; KI-67 ANTIGEN; NEOPLASM PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; TUMOR MARKERS, BIOLOGICAL;

EID: 0029793758     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199608)179:4<386::AID-PATH631>3.0.CO;2-V     Document Type: Article

References (40)

1. Franke WW, Schmid E, Schiller DL, et al. Differentiation-related patterns of expression of proteins of intermediate-sized filaments in tissues and cultured cells. Cold Spring Harb Symp Quant Biol 1982; 46: 431-453.
2. Osborn M, Weber K. Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology. Lab Invest 1983; 48: 372-388.
3. Fuchs E, Tyner AL, Giudice GJ, et al. The human keratin genes and their differential expression. Curr Top Dev Biol 1987; 22: 5-34.
4. Nagle RB. Intermediate filaments: a review of the basic biology. Am J Surg Pathol 1988; 12(Suppl 1): 4-16.
5. Alberts K, Fuchs E. The molecular biology of intermediate filaments. Int Rev Cytol 1992; 134: 243-279.
6. Connel ND, Rheinwald JG. Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture. Cell 1983; 34: 245-253.
7. Schmid E, Schiller DL, Grund C, Stadler J, Franke WW. Tissue type-specific expression of intermediate filament proteins in a cultured epithelial cell line from bovine mammary gland. J Cell Biol 1983; 96: 37-50.
8. Ben-Ze'ev A. Differential control of cytokeratins and vimentin synthesis by cell-cell contact and cell spreading in cultured epithelial cells. J Cell Biol 1984; 99: 1424-1433.
9. Ben-Ze'ev A. Cell-cell interaction and cell configuration related control of cytokeratins and vimentin expression in epithelial cells and in fibroblasts. In: Wang E, et al. eds. Intermediate Filaments. Ann NY Acad Sci 1985; 445: 597.
10. Rheinwald JG, O'Connell TM, Connell ND, et al. Expression of specific keratin subsets and vimentin in normal human epithelial cells: a function of cell type and conditions of a growth during serial culture. Cancer Cells 1986; 1:217.
11. Agnor C, Walker-Jones D, Valverins E, et al. Vimentin expression characterizes hormone-independent breast cancer cell lines and mammary epithelial cells transformed by two oncogenes. Proc Am Assoc Cancer Res 1987; 28: 11 (Abstract 41).
12. Fuchs E. Epidermal differentiation. Curr Op Cell Biol 1990; 2: 1028-1035.
13. Moll R, Franke WW, Schiller DL, Geiger B, Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors, and cultured cells. Cell 1982; 31: 11-24.
14. Taylor-Papadimitriou J, Lane EB. Keratin expression in the mammary gland. In: Neville MC, Daniels C, eds. The Mammary Gland: Development, Regulation, and Function. New York: Plenum Press, 1987; 181-215.
15. Bocker W, Bier B, Freytag G, et al. An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part 1: normal breast and benign proliferative lesions. Virchows Arch A [Pathol Anat] 1992; 421: 315-322.
16. Altmannsberger M, Osborn M, Holscher A, Schauer A, Weber K. The distribution of keratin type intermediate filaments in human breast cancer. Virchows Arch B [Cell Pathol] 1981; 37: 277-284.
17. Altmannsberger M, Dirk T, Droese M, Weber K, Osborn M. Keratin polypeptide distribution in benign and malignant breast tumors: subdivision of ductal carcinomas using monoclonal antibodies. Virchows Arch B [Cell Pathol] 1986; 51: 265-275.
18. Nagle RB, Bocker W, Davis JR, et al. Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithehal from luminal epithelial cells. J Histochem Cytochem 1986; 34: 869-881.
19. Dairkee SH, Puett L, Hackett AJ. Expression of basal and luminal epithelium-specific keratins in normal, benign, and malignant breast tissue. J Natl Cancer Inst 1988; 80: 691-695.
20. Guelstein VI, Tchypysheva TA, Ermilova VD, Litvinova LV, Troyanovsky SM, Bannikov GA. Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. Int J Cancer 1988; 42: 147-153.
21. Jarasch E-D, Nagle RB, Kaufman M, Maurer C, Bocker WJ. Differential diagnosis of benign epithelial proliferations and carcinomas of the breast using antibodies to cytokeratins. Hum Pathol 1988; 19: 276-289.
22. Pellegrino MB, Asch BB, Connolly JL, Asch HL. Differential expression of keratins 13 and 16 in normal epithelium, benign lesions, and ductal carcinomas of the human breast determined by the monoclonal antibody Ks8. 12. Cancer Res 1988; 48: 5831-5836.
23. Gould VE, Koukoulis GK, Jansson DS, Nagle RB, Franke WW, Moll R. Coexpression patterns of vimentin and glial filament protein with cytokeratins in the normal, hyperplastic, and neoplastic breast. Am J Pathol 1990; 137: 1143-1155.
24. Heatley M, Maxwell P, Whiteside C, Toner P. Cytokeratin intermediate filament expression in benign and malignant breast disease. J Clin Pathol 1995; 48: 26-32.
25. Cattoretti G, Andreola S, Clemente C, D'Amato L, Rilke F. Vimentin and p53 expression on epidermal growth factor receptor-positive, oestrogen receptor-negative breast carcinomas. Br J Cancer 1988; 57: 353-357.
26. Raymond WA, Leong AS-Y. Coexpression of cylokeratin and vimentin intermediate filament proteins in benign and malignant breast epithelium. J Pathol 1989; 157: 299-306.
27. Domagala W, Lasota J, Bartkowiak J, Weber K, Osborn M. Vimentin is preferentially expressed in human breast carcinomas with low oestrogen receptor and high Ki-67 growth fraction. Am J Pathol 1990; 136: 219-227.
28. Domagala W, Wozniak L, Lasota J, Weber K, Osborn M. Vimentin is preferentially expressed in high-grade ductal and medullary, but not in lobular breast carcinomas. Am J Pathol 1990; 137: 1059-1064.
29. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. 1. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991; 19: 403-410.
30. Santini D, Ceccarelli C, Mazzoleni G, Pasquinelli G, Jasonni VM, Martinelli GN. Demonstration of cytokeratin intermediate filaments in oocytes of the developing and adult human ovary. Histochemistry 1993; 99: 311-319.
31. Ceccarelli C, Santini D, Chieco P, Taffurelli M, Marrano D, Mancini AM. Multiple expression patterns of biopathological markers in primary invasive breast carcinoma: a useful tool for elucidating its biological behaviour. Ann Oncol 1995; 6: 275-282.
32. Wetzels RHW, Kuijpers HJH, Lane EB, et al. Basal cell-specific and hyperproliferation-related keratins in human breast cancer. Am J Pathol 1991; 138: 751-763.
33. Weiss RA, Eichner RA, Sun T-T. Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kilodalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol 1984; 98: 1397-1406.
34. Quinlan RA, Schiller DL, Hatzfeld M, et al. Patterns of expression and organization of cytokeratin intermediate filaments. Ann NY Acad Sci 1985; 455: 282-306.
35. Tyner AL, Fuchs E. Evidence for post-transcriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis. J Cell Biol 1986; 103: 1945-1955.
36. Galvin S, Loomis C, Manabe M, Dhouailly D, Sun T-T. The major pathways of keratinocyte differentiation as defined by keratin expression: an overview. Adv Dermatol 1989; 4: 277-300.
37. Gusterson BA, Warburton MJ, Mitchell D, Ellison M, Neville AM, Rudland PS. Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases. Cancer Res 1982; 42: 4763-4770.
38. Tsubura A, Okada H, Senzaki H, Hatano T, Morii S. Keratin expression in the normal breast and in breast carcinoma. Histopathotogy 1991; 18: 716-724.
39. Wetzels RHW, Holland R, van Haelst UJGM, Lane EB, Leigh IM, Ramaekers FCS. Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast. Am J Pathol 1989; 134: 571-579.
40. Ferrari S, Bettini R, Kaczmarek L, et al. Coding sequence and growth regulation of the human vimentin gene. Mol Cell Biol 1986; 6: 3614-3620.