A new strategy for the identification of novel molecules with targeted proresolution of inflammation properties

Journal of Immunology

Volumn 184, Issue 3, 2010, Pages 1516-1525

  Navarro Xavier, Roberta A ^a,c   Newson, Justine ^a   Silveira, Vera Lucia Flor ^c   Farrow, Stuart N ^b   Gilroyand, Derek W ^a   Bystrom, Jonas ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

15 EPI LIPOXIN A4; 5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; ANTIINFLAMMATORY AGENT; AZITHROMYCIN; DEXAMETHASONE; IBUPROFEN; LIPOXIN A; RESOLVIN E1; ROLIPRAM; UNCLASSIFIED DRUG; ZYMOSAN; AUTACOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; HOMEOSTASIS; INFLAMMATION; LYMPHOCYTE SUBPOPULATION; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEUM; PERITONITIS; PHENOTYPE; PRIORITY JOURNAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MOTION; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG EFFECT; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LYMPHOCYTE; METHODOLOGY; PATHOLOGY;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; HOMEOSTASIS; INFLAMMATION MEDIATORS; INJECTIONS, INTRAPERITONEAL; LYMPHOCYTES; MACROPHAGES; MICE; MICE, INBRED C57BL; NEUTROPHILS; PERITONITIS; ZYMOSAN;

EID: 77949317772     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902866     Document Type: Article

References (22)

1. Majno, G., and I. Joris. 2004. Cells, Tissues and Disease. Principles of General Pathology. Oxford University Press, New York.
2. Gilroy, D.W., T. Lawrence, M. Perretti, and A. G. Rossi. 2004. Inflammatory resolution: new opportunities for drug discovery. Nat. Rev. Drug Discov. 3: 401-416.
3. Serhan, C. N., S. D. Brain, C. D. Buckley, D. W. Gilroy, C. Haslett, L. A. O'Neill, M. Perretti, A. G. Rossi, and J. L. Wallace. 2007. Resolution of inflammation: state of the art, definitions and terms. FASEB J. 21: 325-332.
4. Serhan, C. N., and J. Savill. 2005. Resolution of inflammation: the beginning programs the end. Nat. Immunol. 6: 1191-1197.
5. Furst, D. E., F. C. Breedveld, J. R. Kalden, J. S. Smolen, G. R. Burmester, M. Dougados, P. Emery, A. Gibofsky, A. F. Kavanaugh, E. C. Keystone, et al. 2003. Updated consensus statement on biological agents for the treatment of rheumatoid arthritis and other immune mediated inflammatory diseases (May 2003). Ann. Rheum. Dis. 62(Suppl 2): ii2-ii9.
6. Hunsche, E., J. V. Chancellor, and N. Bruce. 2001. The burden of arthritis and nonsteroidal anti-inflammatory treatment. A European literature review. Pharmacoeconomics 19(Suppl 1): 1-15.
7. Lawrence, T., D. A. Willoughby, and D. W. Gilroy. 2002. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat. Rev. Immunol. 2: 787-795.
8. Hallett, J. M., A. E. Leitch, N. A. Riley, R. Duffin, C. Haslett, and A. G. Rossi. 2008. Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation. Trends Pharmacol. Sci. 29: 250-257.
9. Bystrom, J., I. Evans, J. Newson, M. Stables, I. Toor, N. van Rooijen, M. Crawford, P. Colville-Nash, S. Farrow, and D. W. Gilroy. 2008. Resolution-phase macrophages possess a unique inflammatory and bactericidal phenotype that is controlled by cAMP. Blood 112: 4117-4127.
10. McLoughlin, R. M., B. J. Jenkins, D. Grail, A. S. Williams, C. A. Fielding, C. R. Parker, M. Ernst, N. Topley, and S. A. Jones. 2005. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proc. Natl. Acad. Sci. USA 102: 9589-9594.
11. Rajakariar, R., T. Lawrence, J. Bystrom, M. Hilliard, P. Colville-Nash, G. Bellingan, D. Fitzgerald, M. M. Yaqoob, and D. W. Gilroy. 2008. Novel biphasic role for lymphocytes revealed during resolving inflammation. Blood 111: 4184-4192.
12. Bannenberg, G. L., N. Chiang, A. Ariel, M. Arita, E. Tjonahen, K. H. Gotlinger, S. Hong, and C. N. Serhan. 2005. Molecular circuits of resolution: formation and actions of resolvins and protectins. J. Immunol. 174: 4345-4355.
13. 2. Proc. Natl. Acad. Sci. USA 104: 20979-20984.
14. Jamieson, T., D. N. Cook, R. J. Nibbs, A. Rot, C. Nixon, P. McLean, A. Alcami, S. A. Lira, M. Wiekowski, and G. J. Graham. 2005. The chemokine receptor D6 limits the inflammatory response in vivo. Nat. Immunol. 6: 403-411.
15. Hurst, S. M., T. S. Wilkinson, R. M. McLoughlin, S. Jones, S. Horiuchi, N. Yamamoto, S. Rose-John, G. M. Fuller, N. Topley, and S. A. Jones. 2001. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14: 705-714.
16. Savill, J., and V. Fadok. 2000. Corpse clearance defines the meaning of cell death. Nature 407: 784-788.
17. Serhan, C. N. 2008. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J. Periodontol. 79: 1520-1526.
18. Pillemer, L., L. Blum, J. Pensky, and I. H. Lepow. 1953. The requirement for magnesium ions in the inactivation of the third component of human complement (C'3) by insoluble residues of yeast cells (zymosan). J. Immunol. 71: 331-338.
19. Pillemer, L., and E. E. Ecker. 1941. Anticomplementary factor in fresh yeast. J. Biol. Chem. 137: 139-142.
20. Liu, Y., J. M. Cousin, J. Hughes, J. Van Damme, J. R. Seckl, C. Haslett, I. Dransfield, J. Savill, and A. G. Rossi. 1999. Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. J. Immunol. 162: 3639-3646. (Pubitemid 29313619)
21. Parnham, M. J. 2005. Immunomodulatory effects of antimicrobials in the therapy of respiratory tract infections. Curr. Opin. Infect. Dis. 18: 125-131.
22. Carding, S. R., and P. J. Egan. 2000. The importance of γδ T cells in the resolution of pathogen-induced inflammatory immune responses. Immunol. Rev. 173: 98-108.