Chemoenzymatic synthesis of α-Hydroxy-β-methyl-γ-hydroxy esters: Role of the keto-enol equilibrium to control the stereoselective hydrogenation in a key step

Journal of Organic Chemistry

Volumn 75, Issue 5, 2010, Pages 1410-1418

  Milagre, Cintia D F ^a,b   Milagre, Humberto M S ^a,b   Moran, Paula J S ^a,b   Rodrigues, J Augusto R ^a,b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

[CARBONYL; BIOLOGICAL ACTIVITIES; BIOREDUCTIONS; CHEMICAL EQUATIONS; CHEMO-ENZYMATIC SYNTHESIS; CHEMOENZYMATIC APPROACHES; DIASTEREOSELECTIVE; ENANTIO; ENANTIOMERIC EXCESS; FUNCTIONALIZED; GLOBAL YIELD; HYDROXY ESTERS; KETO-ENOL EQUILIBRIA; KETOESTER; KEY REACTIONS; NATURAL PRODUCTS; OLEFINATION; ORGANIC SYNTHESIS; POTENT DRUGS; STEREOGENIC CENTERS; STEREOSELECTIVE HYDROGENATION;

CHEMICAL COMPOUNDS; ESTERIFICATION; PALLADIUM; REACTION INTERMEDIATES; STEREOSELECTIVITY;

ESTERS;

ALPHA HYDROXY BETA METHYL GAMMA HYDROXY ESTER DERIVATIVE; ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; HYDROGENATION; MANNICH REACTION; STEREOCHEMISTRY; SYNTHESIS;

ALKENES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; ESTERS; HYDROGEN-ION CONCENTRATION; HYDROGENATION; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PHENYLPROPIONATES; STEREOISOMERISM;

EID: 77949297701     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo902227f     Document Type: Article

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