Antibacterial activity, bioavailability and acute toxicity evaluation of the lear extract of Alchornea cordifolia (Euphorbiaceae)

International Journal of Pharmacology

Volumn 6, Issue 3, 2010, Pages 173-182

  Gatsing, Donatien ^a   Nkeugouapi, Christiane F N ^a   Nji Nkah, Bridget F ^a   Kuiate, Jules Roger ^a   Tchouanguep, Félicité M ^a  

^a UNIVERSITY OF DSCHANG   (Cameroon)

Author keywords

Alchornea cordifolia leaves; Antimicrobial; Bioavailability; LD50; Phytochemical

Indexed keywords

ALCHORNEA CORDIFOLIA EXTRACT; ANTHOCYANIN; EUPHORBIA EXTRACT; FLAVONOID; POLYPHENOL; SAPONIN; STEROID; TANNIN; TRITERPENE; UNCLASSIFIED DRUG;

AGAR DIFFUSION; ALCHORNEA CORDIFOLIA; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; AREA UNDER THE CURVE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG SCREENING; ESCHERICHIA COLI; EUPHORBIA; FEMALE; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; LD 50; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NOCICEPTION; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; SWISS WEBSTER MOUSE; TOXICITY TESTING;

EID: 77949292663     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2010.173.182     Document Type: Article

References (30)

1. Abid, M., H.J. Hrishikeshavan and M. Asad, 2006. Pharmacological evaluation of Pachyrrhizus erosus (L.) seeds for central nervous system depressant activity. Indian J. Physiol. Pharmacol., 50: 143-151.
2. Akendengue, B. and A.M. Louis, 1994. Medicinal plant used by the Massango people in Gabon. J. Ethnopharmacol., 41: 193-200.
3. Biber, A., H. Fischer, A. Romer and S.S. Chatteriee, 1998. Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers. Pharmacopsychiatry, 31: 36-43.
4. Bourne, W., 2008. A first course in pharmacokinetics and biopharmaceutics. http://www.boomer.org/c/pl/.
5. Brooks, G.F., J.S. Butel and L.N. Ornston, 1991. Jawetz, Melnick and Adelberg's Medical Microbiology. Prentice-Hall, New York.
6. Bruneton, J., 1999. Pharmacognosie: Phytochimie-Plantes Médicinales. Tec and Doc, Paris.
7. Carbonnelle, B., F. Denis, A. Marmonier, G. Pinon and R. Vague, 1987. Bactériologie Médicale: Techniques Usuelles. SIMEP, Paris, ISBN: 2-85334-276-X.
8. Chakraborty, A., R.K.B. Devi, S. Rita, K.H. Sharatchandra and T.I. Singh, 2004. Preliminary studies on anti inflammatory and analgesic activities of Spilanthes acmella in experimental animal models. Indian J. Pharacol., 36: 148-150.
9. Cheesbrough, M., 1991. Medical Laboratory Manual for Tropical Countries. Vol. II., Microbiology Tropical Health Technology/Buterworths Scientific Publications, Boston, pp: 167-214.
10. Cowan, M.M., 1999. Plant products as antimicrobial agents. Clin. Microbiol. Rev., 12: 564-582.
11. Craig, W.A., 1998. Basic pharmacokinetic/pharmacodynamic parameters: Rationale for antibacterial dosing of mice and men. Clin. Infect. Dis., 26: 1-12.
12. Delongeas, J.L., D. Burnel, P. Netter, M. Grignon, J.M. Mur, R.J. Royer and G. Grignon, 1983. Toxicité et pharmacocinétique de l'oxychlorure de zirconium chez les souris et les rats. J. Pharmacol., 14: 437-447.
13. Gatsing, D. and G.I. Adoga, 2007. Antisalmonellal activity and phytochemical screening of the various parts of Cassia petersiana bolle (Caesalpiniaceae). Res. J. Microbiol., 2: 876-880.
14. Gatsing, D., J.A. Mbah, I.H. Garba, P. Tane, P. Djemgou and B.F. Nji-Nkah, 2006. An antisalmonellal agent from the leaves of Glossocalyx brevipes Benth (Monimiaceae). Pak. J. Biol. Sci., 9: 84-87.
15. Gatsing, D., R. Ahyu, J.R. Kuiate, I.H. Garba and K.H. Jaryum et al., 2005. Toxicological evaluation of the aqueous extract of Allium sativum bulbs on laboratory mice and rats. Cameroon J. Exp. Biol., 1: 39-45.
16. Gatsing, D., T.S. Moudji, J.R. Kuiate, F.B.N. Nkah and C.S.P. Fodouop et al., 2008. In vitro antibacterial activity of Alchornea cordifolia bark extract against Salmonella species causing typhoid fevers. Ethiop. Pharm. J., 26: 83-94.
17. Gatsing, D., V. Tchakoute, D. Ngamga, J.R. Kuiate and J.D.D. Tamokou et al., 2009. In vitro antibacterial activity of Crinum purpurascens Herb. leaf extract against the Salmonella species causing typhoid fever and its toxicological evaluation. Iran. J. Med. Sci., 34: 126-136.
18. Liao, Q., W. Yang, Y. Jia, X. Chen, Q. Gaoand K. Bi, 2005. LC-MS Determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional Chinese medicinal preparation Lu-Ying extract. Yakugaku Zasshi, 125: 509-515.
19. Mosihuzzaman, M. and M.I. Choudhary, 2008. Protocols on safety, efficacy, standardization, and documentation of herbal medicine. Pure Appl. Chem., 80: 2195-2230.
20. Neuwinger, H.D., 2000. African Traditional Medicine, A Dictionary of Plant Use and Applications. 1st Edn. Medpharm Scientific Publishers, Stuttgart, ISBN: 978-3887630867.
21. Nguelefack, T.B., A.L. Fotio, P. Watcho, S.L. Wansi, T. Dimo and A. Kamanyi, 2004. Analgesic properties of the aqueous and ethanol extracts of the leaves of Kalanchoe crenata (Crussaceae). Phytother. Res., 18: 385-388.
22. Okeke, I.N., A.O. Ogundaini, F.O. Ogungbamila and A. Lamikanra, 1999. Antimicrobial spectrum of Alchornea cordifolia leaf extract. Phytother. Res., 13: 67-69.
23. Olaleye, M.T., O.O. Adegboye and A.A. Akindahunsi, 2006. Alchornea cordifolia extract protects Wistar albino rats against acetaminophen-induced liver damage. Afr. J. Biotechnol., 5: 2439-2445.
24. Olaleye, M.T., A.O. Kolawole and J.O. Ajele, 2007. Antioxidant properties and glutathione S-transferases inhibitory activity of Alchornea cordifolia leaf extract in acetaminophen-induced liver injury. Iranian J. Pharmacol. Ther., 6: 63-66.
25. Osadebe, P.O. and F.B.C. Okoye, 2003. Anti-inflammatory effects of crude methanolic extracts and fractions of Alchornea cordifolia leaves. J. Ethnopharmacol., 89: 19-24.
26. Teke, N.G., J.R. Kuiate, B.O. Ngouateu and D. Gatsing, 2007. Antidiarrheal and antimicrobial activities of Emilia coccinea (Sims) G. Don extracts. J. Ethnopharmacol., 112: 278-283.
27. Tona, L., K. Kambu, N. Ngimbi, K. Climanga and A.J. Vlietinck, 1998. Antiamoebic and phytochemical screening of some congolese medicinal plants. J. Ethnopharmacol., 61: 57-65.
28. Tona, L., K. Kambu, N. Ngimbi, K. Mesia and O. Penge et al., 2000. Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo. Phytomedicine, 7: 31-38.
29. Trofimiuk, E., A. Walesiuk and J.J. Braszko, 2005. St John's wort (Hyperium perforatum) diminishes cognitive impairment caused by the chronic restraint stress in rats. Pharmacol. Res., 51: 239-246.
30. Youmans, G.P., P.Y. Paterson and H.M. Sommers, 1975. The Biologic and Clinical Basis of Infectious Diseases. WB. Saunders Co., New York.