메뉴 건너뛰기




Volumn 117, Issue 1, 2010, Pages 139-145

Lack of evidence for fracture prevention in early breast cancer bisphosphonate trials: A meta-analysis

Author keywords

Adjuvant; Bisphosphonates; Breast cancer; Fractures

Indexed keywords

AROMATASE INHIBITOR; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; IBANDRONIC ACID; PAMIDRONIC ACID; PLACEBO; RISEDRONIC ACID; ZOLEDRONIC ACID;

EID: 77949288236     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2009.12.001     Document Type: Review
Times cited : (34)

References (36)
  • 1
    • 0034037097 scopus 로고    scopus 로고
    • Osteoporosis due to cancer treatment: pathogenesis and management
    • Pfeilschifter J., and Diel I.J. Osteoporosis due to cancer treatment: pathogenesis and management. J. Clin. Oncol. 18 (2000) 1570-1593
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1570-1593
    • Pfeilschifter, J.1    Diel, I.J.2
  • 2
    • 0035879298 scopus 로고    scopus 로고
    • Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer
    • Shapiro C.L., Manola J., and Leboff M. Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer. J. Clin. Oncol. 19 (2001) 3306-3311
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3306-3311
    • Shapiro, C.L.1    Manola, J.2    Leboff, M.3
  • 3
    • 0032512906 scopus 로고    scopus 로고
    • Bone loss induced by cancer treatment and its management
    • Delmas P.D., and Fontana A. Bone loss induced by cancer treatment and its management. Eur. J. Cancer. 34 (1998) 260-262
    • (1998) Eur. J. Cancer. , vol.34 , pp. 260-262
    • Delmas, P.D.1    Fontana, A.2
  • 4
    • 33746455931 scopus 로고    scopus 로고
    • Effect of an aromatase inhibitor on BMD and bone turnover markers: 2-year results of the Anastrozole, Tamoxifen, alone or in combination (ATAC) trial (18233230)
    • Eastell R., Hannon R.A., Cuzick J., Dowsett M., Clack G., and Adams J.E. Effect of an aromatase inhibitor on BMD and bone turnover markers: 2-year results of the Anastrozole, Tamoxifen, alone or in combination (ATAC) trial (18233230). J. Bone Miner. Res. 21 (2006) 1215-1223
    • (2006) J. Bone Miner. Res. , vol.21 , pp. 1215-1223
    • Eastell, R.1    Hannon, R.A.2    Cuzick, J.3    Dowsett, M.4    Clack, G.5    Adams, J.E.6
  • 5
    • 33745931630 scopus 로고    scopus 로고
    • Risk of cancer treatment-associated bone loss and fractures among women with breast cancer receiving aromatase inhibitors
    • Mincey B.A., Duh M.S., Thomas S.K., Moyneur E., Marynchencko M., Boyce S.P., et al. Risk of cancer treatment-associated bone loss and fractures among women with breast cancer receiving aromatase inhibitors. Clin. Breast Cancer 7 (2006) 127-132
    • (2006) Clin. Breast Cancer , vol.7 , pp. 127-132
    • Mincey, B.A.1    Duh, M.S.2    Thomas, S.K.3    Moyneur, E.4    Marynchencko, M.5    Boyce, S.P.6
  • 6
    • 33747058527 scopus 로고    scopus 로고
    • Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA. 17
    • Perez E.A., Josse R.G., Pritchard K.I., Ingle J.N., Martino S., Findlay B.P., et al. Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA. 17. J. Clin. Oncol. 24 (2006) 3629-3635
    • (2006) J. Clin. Oncol. , vol.24 , pp. 3629-3635
    • Perez, E.A.1    Josse, R.G.2    Pritchard, K.I.3    Ingle, J.N.4    Martino, S.5    Findlay, B.P.6
  • 7
    • 33846545488 scopus 로고    scopus 로고
    • Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in post-menopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomized controlled study
    • Coleman R.E., Banks L.M., Girgis S.I., Kilburn L.S., Vrdoljak E., Fox J., et al. Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in post-menopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomized controlled study. Lancet. Oncol. 8 (2007) 119-127
    • (2007) Lancet. Oncol. , vol.8 , pp. 119-127
    • Coleman, R.E.1    Banks, L.M.2    Girgis, S.I.3    Kilburn, L.S.4    Vrdoljak, E.5    Fox, J.6
  • 8
    • 0032504985 scopus 로고    scopus 로고
    • Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group
    • Cummings S.R., Browner W.S., Bauer D., Stone K., Ensrud K., Jamal S., et al. Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. N. Engl. J. Med. 339 (1998) 733-738
    • (1998) N. Engl. J. Med. , vol.339 , pp. 733-738
    • Cummings, S.R.1    Browner, W.S.2    Bauer, D.3    Stone, K.4    Ensrud, K.5    Jamal, S.6
  • 9
    • 22144497431 scopus 로고    scopus 로고
    • Osteoporosis in breast and prostate cancer survivors
    • Hoff A.O., and Gagel R.F. Osteoporosis in breast and prostate cancer survivors. Oncology (Williston. Park) 19 (2005) 651-658
    • (2005) Oncology (Williston. Park) , vol.19 , pp. 651-658
    • Hoff, A.O.1    Gagel, R.F.2
  • 10
    • 40149083563 scopus 로고    scopus 로고
    • Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel
    • Aapro M., Abrahamsson P.A., Body J.J., Coleman R.E., Colomer R., Costa L., et al. Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel. Ann. Oncol. 19 (2008) 420-432
    • (2008) Ann. Oncol. , vol.19 , pp. 420-432
    • Aapro, M.1    Abrahamsson, P.A.2    Body, J.J.3    Coleman, R.E.4    Colomer, R.5    Costa, L.6
  • 11
    • 0030693603 scopus 로고    scopus 로고
    • Quantitative synthesis in systematic reviews
    • Lau J., Ioannidis J.P., and Schmid C.H. Quantitative synthesis in systematic reviews. Ann. Intern. Med. 127 (1997) 820-826
    • (1997) Ann. Intern. Med. , vol.127 , pp. 820-826
    • Lau, J.1    Ioannidis, J.P.2    Schmid, C.H.3
  • 13
    • 48749106052 scopus 로고    scopus 로고
    • The effect of zoledronic acid on aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: the Z-FAST study 36-month follow-up
    • [Abstract 27]
    • Brufsky A., Bosserman L., Caradonna R., Haley B., Jones M., Moore H., et al. The effect of zoledronic acid on aromatase inhibitor-associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: the Z-FAST study 36-month follow-up. Breast Cancer Res. Treat. 106 Suppl. 1 (2007) S8 [Abstract 27]
    • (2007) Breast Cancer Res. Treat. , vol.106 , Issue.SUPPL. 1
    • Brufsky, A.1    Bosserman, L.2    Caradonna, R.3    Haley, B.4    Jones, M.5    Moore, H.6
  • 14
    • 70349757135 scopus 로고    scopus 로고
    • The effect of zoledronic acid on aromatase inhibitor associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36 months follow-up of ZO-FAST
    • Abstract 44
    • Eidtmann H, Bundred NJ, DeBoer R, Llombart A, Davidson N, Neven P, et al. The effect of zoledronic acid on aromatase inhibitor associated bone loss in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36 months follow-up of ZO-FAST. 2008 San Antonio Breast Cancer Symposium, Abstract 44 (http://www.abstracts2view.com/sabcs/).
    • (2008) San Antonio Breast Cancer Symposium
    • Eidtmann, H.1    Bundred, N.J.2    DeBoer, R.3    Llombart, A.4    Davidson, N.5    Neven, P.6
  • 15
    • 45749127094 scopus 로고    scopus 로고
    • Risedronate prevents bone loss in breast cancer survivors: a 2-year, randomized, double-blind, placebo-controlled clinical trial
    • Greenspan S.L., Brufsky A., Lembersky B.C., Bhattacharya R., Vujevich K.T., Perera S., et al. Risedronate prevents bone loss in breast cancer survivors: a 2-year, randomized, double-blind, placebo-controlled clinical trial. J. Clin. Oncol. 26 (2008) 2644-2652
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2644-2652
    • Greenspan, S.L.1    Brufsky, A.2    Lembersky, B.C.3    Bhattacharya, R.4    Vujevich, K.T.5    Perera, S.6
  • 16
    • 58149166777 scopus 로고    scopus 로고
    • Prevention of anastrazole-induced bone loss with monthly oral ibandronate during adjuvant aromatase inhibitor therapy for breast cancer
    • Lester J.E., Dodwell D., Purohit O.P., Gutcher S.A., Ellis S.P., Thorpe R., et al. Prevention of anastrazole-induced bone loss with monthly oral ibandronate during adjuvant aromatase inhibitor therapy for breast cancer. Clin. Cancer Res. 14 (2008) 6336-6342
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6336-6342
    • Lester, J.E.1    Dodwell, D.2    Purohit, O.P.3    Gutcher, S.A.4    Ellis, S.P.5    Thorpe, R.6
  • 17
    • 52749090158 scopus 로고    scopus 로고
    • N03CC-a randomized, controlled, open-label trial of upfront vs. delayed zoledronic acid for prevention of bone loss in postmenopausal (PM) women with primary breast cancer (PBC) starting letrozole after tamoxifen
    • (Suppl) [abstract 564]
    • Mincey B.A., Dentchev T., Sloan J.A., Hines S.L., Perez E.A., Johnson D.B., et al. N03CC-a randomized, controlled, open-label trial of upfront vs. delayed zoledronic acid for prevention of bone loss in postmenopausal (PM) women with primary breast cancer (PBC) starting letrozole after tamoxifen. J. Clin. Oncol. 26 (2008 May 20) (Suppl) [abstract 564]
    • (2008) J. Clin. Oncol. , vol.26
    • Mincey, B.A.1    Dentchev, T.2    Sloan, J.A.3    Hines, S.L.4    Perez, E.A.5    Johnson, D.B.6
  • 19
    • 44649158459 scopus 로고    scopus 로고
    • The E-ZO-FAST trial: zoledronic acid (ZA) effectively inhibits aromatase inhibitor associated bone loss (AIBL) in postmenopausal women (PMW) with early breast cancer (EBC) receiving adjuvant letrozole (Let)
    • [Abstract 2008]
    • Schenk N., Lombart A., Frassoladti A., Neven P., Jerusalem G., Deleu I., et al. The E-ZO-FAST trial: zoledronic acid (ZA) effectively inhibits aromatase inhibitor associated bone loss (AIBL) in postmenopausal women (PMW) with early breast cancer (EBC) receiving adjuvant letrozole (Let). Eur. J. Cancer 5 Suppl. 5 (2007) 186-187 [Abstract 2008]
    • (2007) Eur. J. Cancer , vol.5 , Issue.SUPPL. 5 , pp. 186-187
    • Schenk, N.1    Lombart, A.2    Frassoladti, A.3    Neven, P.4    Jerusalem, G.5    Deleu, I.6
  • 20
    • 70349992840 scopus 로고    scopus 로고
    • Effect of zoledronic acid (ZA) on bone mineral density (BMD) in premenopausal women who developed ovarian failure (OF) due to adjuvant chemotherapy (AdC): First results of GALGB trial 79809
    • (Suppl) [abstract 512]
    • Shapiro C.L., Halabi S., Gibson G., Weckstein D.J., Kirshner J., Sikov W.M., et al. Effect of zoledronic acid (ZA) on bone mineral density (BMD) in premenopausal women who developed ovarian failure (OF) due to adjuvant chemotherapy (AdC): First results of GALGB trial 79809. J. Clin. Oncol. 26 (2008 May 20) (Suppl) [abstract 512]
    • (2008) J. Clin. Oncol. , vol.26
    • Shapiro, C.L.1    Halabi, S.2    Gibson, G.3    Weckstein, D.J.4    Kirshner, J.5    Sikov, W.M.6
  • 21
    • 54249151531 scopus 로고    scopus 로고
    • Zoledronic acid prevents bone loss in premenopausal women undergoing adjuvant chemotherapy for early-stage breast cancer
    • Hershman D.L., McMahon D.J., Crew K.D., Cremers S., Irani D., Cucchiara G., et al. Zoledronic acid prevents bone loss in premenopausal women undergoing adjuvant chemotherapy for early-stage breast cancer. J. Clin. Oncol. 26 (2008) 4739-4745
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4739-4745
    • Hershman, D.L.1    McMahon, D.J.2    Crew, K.D.3    Cremers, S.4    Irani, D.5    Cucchiara, G.6
  • 22
    • 52749084906 scopus 로고    scopus 로고
    • N02C1: a phase III randomized, placebo-controlled, double-blind trial of risedronate for prevention of bone loss in premenopausal women undergoing adjuvant chemotherapy for breast cancer (BC)
    • (Suppl) [abstract 525]
    • Hines S.L., Mincey B.A., Sloan J.A., Thomas S.P., Chottiner E.G., Loprinzi C.L., et al. N02C1: a phase III randomized, placebo-controlled, double-blind trial of risedronate for prevention of bone loss in premenopausal women undergoing adjuvant chemotherapy for breast cancer (BC). J. Clin. Oncol. 26 (2008 May 20) (Suppl) [abstract 525]
    • (2008) J. Clin. Oncol. , vol.26
    • Hines, S.L.1    Mincey, B.A.2    Sloan, J.A.3    Thomas, S.P.4    Chottiner, E.G.5    Loprinzi, C.L.6
  • 23
    • 49949115926 scopus 로고    scopus 로고
    • Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy
    • Gnant M., Mlineritsch B., Luschin-Ebengreuth G., Kainberger F., Kassmann H., Piswanger-Solkner J.D., et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy. Lancet Oncol. 9 (2008) 840-849
    • (2008) Lancet Oncol. , vol.9 , pp. 840-849
    • Gnant, M.1    Mlineritsch, B.2    Luschin-Ebengreuth, G.3    Kainberger, F.4    Kassmann, H.5    Piswanger-Solkner, J.D.6
  • 24
    • 0031057249 scopus 로고    scopus 로고
    • Bisphosphonate risedronate prevents bone loss in women with artificial menopause due to chemotherapy of breast cancer: a double-blind, placebo-controlled study
    • Delmas P.D., Balena R., Confravreux E., Hardouin C., Hardy P., and Bremond A. Bisphosphonate risedronate prevents bone loss in women with artificial menopause due to chemotherapy of breast cancer: a double-blind, placebo-controlled study. J. Clin. Oncol. 15 (1997) 955-962
    • (1997) J. Clin. Oncol. , vol.15 , pp. 955-962
    • Delmas, P.D.1    Balena, R.2    Confravreux, E.3    Hardouin, C.4    Hardy, P.5    Bremond, A.6
  • 25
    • 21244494910 scopus 로고    scopus 로고
    • Pamidronate in the prevention of chemotherapy-induced bone loss in premenopausal women with breast cancer: a randomized controlled trial
    • Fuleihan G.e.l.-H., Salamoun M., Mourad Y.A., Chehal A., Salem Z., Mahfoud Z., et al. Pamidronate in the prevention of chemotherapy-induced bone loss in premenopausal women with breast cancer: a randomized controlled trial. J. Clin. Endocrinol. Metab. 90 (2005) 3209-3214
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 3209-3214
    • Fuleihan, G.e.l.-H.1    Salamoun, M.2    Mourad, Y.A.3    Chehal, A.4    Salem, Z.5    Mahfoud, Z.6
  • 26
    • 0035917670 scopus 로고    scopus 로고
    • The effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer
    • Saarto T., Vehmanen L., Elomaa I., Valimaki M., Makela P., and Blomqvist C. The effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer. Br. J. Cancer 84 (2001) 1047-1051
    • (2001) Br. J. Cancer , vol.84 , pp. 1047-1051
    • Saarto, T.1    Vehmanen, L.2    Elomaa, I.3    Valimaki, M.4    Makela, P.5    Blomqvist, C.6
  • 27
    • 0035196356 scopus 로고    scopus 로고
    • Long-term impact of chemotherapy-induced ovarian failure on bone mineral density (BMD) in premenopausal breast cancer patients. The effect of adjuvant clodronate treatment
    • Vehmanen L., Saarto T., Elomaa I., Makela P., Valimaki M., and Blomqvist C. Long-term impact of chemotherapy-induced ovarian failure on bone mineral density (BMD) in premenopausal breast cancer patients. The effect of adjuvant clodronate treatment. Eur. J. Cancer 37 (2001) 2373-2378
    • (2001) Eur. J. Cancer , vol.37 , pp. 2373-2378
    • Vehmanen, L.1    Saarto, T.2    Elomaa, I.3    Makela, P.4    Valimaki, M.5    Blomqvist, C.6
  • 28
    • 77949290519 scopus 로고    scopus 로고
    • Randomized trial to assess bone mineral density (BMD) effects of zoledronic acid (ZA) in postmenopausal women with breast cancer
    • (18S) [Abstract 19558]
    • Tevaarwerk A., Stewart J.A., Love R., Binkley N.C., Black S., Eickhoff J., et al. Randomized trial to assess bone mineral density (BMD) effects of zoledronic acid (ZA) in postmenopausal women with breast cancer. J. Clin. Oncol. 25 (2007 Jun 20) (18S) [Abstract 19558]
    • (2007) J. Clin. Oncol. , vol.25
    • Tevaarwerk, A.1    Stewart, J.A.2    Love, R.3    Binkley, N.C.4    Black, S.5    Eickhoff, J.6
  • 29
    • 0035148170 scopus 로고    scopus 로고
    • Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial
    • Saarto T., Blomqvist T., Virkkunen P., and Elomaa I. Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial. J. Clin. Oncol. 19 (2001) 10-17
    • (2001) J. Clin. Oncol. , vol.19 , pp. 10-17
    • Saarto, T.1    Blomqvist, T.2    Virkkunen, P.3    Elomaa, I.4
  • 30
    • 45149083364 scopus 로고    scopus 로고
    • Bisphosphonate treatment in primary breast cancer: results from a randomised comparison of oral pamidronate versus no pamidronate in patients with primary breast cancer
    • Kristensen B., Ejlertsen B., Mouridsen H.T., Jensen M.B., Andersen J., Bjerregaard B., et al. Bisphosphonate treatment in primary breast cancer: results from a randomised comparison of oral pamidronate versus no pamidronate in patients with primary breast cancer. Acta Oncol. 47 4 (2008) 740-746
    • (2008) Acta Oncol. , vol.47 , Issue.4 , pp. 740-746
    • Kristensen, B.1    Ejlertsen, B.2    Mouridsen, H.T.3    Jensen, M.B.4    Andersen, J.5    Bjerregaard, B.6
  • 31
    • 33744828376 scopus 로고    scopus 로고
    • Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer
    • Powles T., Paterson S., McCloskey E., Schein P., Scheffler B., Tidy A., et al. Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer. Breast Ca. Res. 8 (2006) R13
    • (2006) Breast Ca. Res. , vol.8
    • Powles, T.1    Paterson, S.2    McCloskey, E.3    Schein, P.4    Scheffler, B.5    Tidy, A.6
  • 33
    • 14844292675 scopus 로고    scopus 로고
    • Fracture risk among breast cancer survivors. Results from the Women's Health Initiative Observational Study
    • Chen Z., Maricic M., Bassford T.L., Pettinger M., Ritenbaugh C., Lopez A.M., et al. Fracture risk among breast cancer survivors. Results from the Women's Health Initiative Observational Study. Arch. Intern. Med. 165 (2005) 552-558
    • (2005) Arch. Intern. Med. , vol.165 , pp. 552-558
    • Chen, Z.1    Maricic, M.2    Bassford, T.L.3    Pettinger, M.4    Ritenbaugh, C.5    Lopez, A.M.6
  • 36
    • 24944481734 scopus 로고    scopus 로고
    • Incidence and prognostic impact of amenorrhea during adjuvant therapy in high-risk premenopausal breast cancer: analysis of a National Cancer Institute of Canada Clinical Trials Group Study-NCIC CTG MA.5
    • Parulekar W.R., Day A.G., Ottaway J.A., Shepherd L.E., Trudeau M.E., Bramwell V., et al. Incidence and prognostic impact of amenorrhea during adjuvant therapy in high-risk premenopausal breast cancer: analysis of a National Cancer Institute of Canada Clinical Trials Group Study-NCIC CTG MA.5. J. Clin. Oncol. 23 (2005) 6002-6008
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6002-6008
    • Parulekar, W.R.1    Day, A.G.2    Ottaway, J.A.3    Shepherd, L.E.4    Trudeau, M.E.5    Bramwell, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.