C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2

Diabetes Research and Clinical Practice

Volumn 88, Issue 1, 2010, Pages 76-80

  de Luis, D A ^a   Sagrado, M Gonzalez ^a   Aller, R ^a   Izaola, O ^a   Conde, R ^a   Romero, E ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Diabetes mellitus; FAAH; Insulin resistance; Polymorphism

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; COMPLEMENTARY DNA; FATTY ACID AMIDASE; INSULIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALLELE; ANTHROPOMETRY; ARTICLE; BIOCHEMISTRY; BODY FAT; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CARBOHYDRATE INTAKE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIETARY INTAKE; DISEASE ASSOCIATION; FAT INTAKE; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITIONAL ASSESSMENT; OBESITY; PROTEIN INTAKE; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WILD TYPE;

ADIPONECTIN; ADULT; AGED; AMIDOHYDROLASES; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; CALORIMETRY; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; DIET; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOOD HABITS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; RESISTIN; STATISTICS, NONPARAMETRIC; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77949275094     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2009.12.019     Document Type: Article

References (27)

1. Aranceta J., Perez Rodrigo C., and Serra Majem L. Prevalencia de la obesidad en España: estudio SEEDO 97. Med. Clin. (Barc.) 111 (1998) 441-445
2. Matsuzawa Y., and Adipocytokines:. Emerging therapeutic targets. Curr. Atheroscler. Rep. 7 (2005) 58-62
3. Ameri A. The effects of cannabinnoids on the brain. Prog. Neurobiol. 58 (1999) 315-348
4. Brown S.M., Warger-Miller J., and Mackie K. Cloning and molecular characterization of the rat CB2 cannabinoid receptor. Biochim. Biophys. Acta 1576 (2002) 255-264
5. Deustch D.G., Ueda N., and Yammamoto S. The fatty acid amide hydrolase (FAAH) 1. Prostaglandins Leukot. Essent. Fatty Acids 66 (2002) 201-210
6. Lichtman A.H., Hawkins E.G., Griffin G., and Cravatt B.F. Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. Pharmacol. Exp. Ther. 302 (2002) 73-79
7. Sipe J.C., Chiang K., Gerber A.L., Beutler E., and Cravatt B.F. A Missense mutation in human fatty acid amide hydroxylase associated with problem drug abuse. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 8394-8399
8. Sipe J.C., Waalen J., Gerber A., and Beutler E. Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). Int. J. Obes. 29 (2005) 755-759
9. Monteleone P., Tortorella A., Martiadis V., Filippo C., Canestrelli B., and Maj M. The CDNA 385 C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. Psychoneuroendocrinology 33 (2008) 546-550
10. Jensen D., Andreasen C., Andersen M., Hansen L., Eiberg H., Borch-Johnsen K., et al. The functional pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5801 whites. J. Mol. Med. 85 (2007) 445-449
11. Duart M.J., Arroyo C.O., and Moreno J.L. Validation of an insulin model for the reactions in RIA. Clin. Chem. Lab. Med. 40 (2002) 1161-1167
12. Mathews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., and Treacher Df. Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-414
13. Pfutzner A., Langefeld M., Kunt T., and Lobig M. Evaluation of human resistin assays with serum from patients with type 2 diabetes and different degrees of insulin resistance. Clin. Lab. 49 (2003) 571-576
14. Meier U., and Gressner M. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin. Chem. 50 (2004) 1511-1525
15. Suominen P. evaluation of an enzyme immunometric assay to measure serum adiponectin concentrations. Clin. Chem. 50 (2004) 219-221
16. Lubrano V., Cocci F., Battaglia D., and Papa A. Usefulness of high-sensitivity IL6 measurement for clinical characterization of patients with coronary artery disease. J. Clin. Lab. Anal. 19 (2005) 110-114
17. Khan S.S., Smith M.S., Reda D., Suffredini A.F., and Mc Coy J.P. Multiplex bead array assays for detection of soluble cytokines: comparisons of sensitivity and quantitative values among kits from multiple manufactures. Cytometry B: Clin. Cytom. 61 (2004) 35-39
18. Feurer I.D., and Mullen J.L. Bedside measurement of resting energy expenditure and respiratory quotient via indirect calorimetry. Nutr. Clin. Pract. 1 (1986) 43-49
19. Pichard C., Slosman D., Hirschel B., and Kyle U. Bioimpedance analysis: an improved method for nutritional follow up. Clin. Res. 41 (1993) 53
20. Mataix J., and Mañas M. Tablas de composición de alimentos españoles (2003), University of Granada
21. Chiang K.P., Gerber A.L., Sipe J.C., and Cravatt B.F. Reduced cellular expression and activity of the P129T mutant fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Hum. Mol. Genet. 13 (2004) 2113-2119
22. Aberle J., Fedderwitz I., Klages N., George E., and Beil F.U. Genetic variation in two proteins of the endocannabinoid system and their influence on body mass index and metabolism under low fat diet. Horm. Metab. Res. 39 (2007) 395-397
23. Papazoglou D., Panagopoulos I., Papanas N., Gioka T., Papadopoulos T., Papathanasiou P., et al. The FAAH Pro129Thr polymorphism is not associated with severe obesity in Greek Subjects. Horm. Metab. Res. 40 (2008) 907-910
24. Egertova M., Cravatt B.F., and Elphick M.R. Comparative analysis of FAAH and CB1 cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signalling. Neuroscience 119 (2003) 481-496
25. Cota D., Marsicano G., Lutz B., Vicennatu V., Stalla G.K., Pasqualli R., et al. endogenous cannabinoid system as a modulator of food intake. Int. J. Obes. Relat. Metab. Disord. 27 (2003) 289-301
26. Salmennienmi U., Zacharova J., Ruotsalainen E., Vauhkonen I., Pihlajamaki J., and Kainulainen S. Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure and cytokines in offspring of type 2 diabetic patients. J. Clin. Endocrinol. Metab. (2005) Epub ahead of print
27. Mantzmoros C.S., Manson J.E., Meigs J., and Hu F.B. Circulating adiponectin levels are associated with better glycemic control, more favourable lipid profile and reduced inflammation in women with type 2 diabetes. J. Clin. Endocrinol. Metab. 90 8 (2005) 4542-4548