Probing the binding pocket of the active site of aromatase with 2-phenylaliphatic androsta-1,4-diene-3,17-dione steroids

Steroids

Volumn 75, Issue 4-5, 2010, Pages 330-337

  Takahashi, Madoka ^a   Yamashita, Kouwa ^a   Numazawa, Mitsuteru ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

2 Phenylaliphatic substituent; Androsta 1,4 diene 3,17 dione; Aromatase; Breast cancer; Competitive inhibitor; Suicide substrate

Indexed keywords

2 BENZYL ANDROSTA 1,4 DIENE 3,17 DIONE; 2 PENTO METHYLPHENETHYL ANDROSTA 1,4 DIENE 3,17 DIONE; 2 PENTO TRIFLUOROMETHYLPHENETHYL ANDROSTA 1,4 DIENE 3,17 DIONE; 2 PHENBUTYL ANDROSTA 1,4 DIENE 3,17 DIONE; 2 PHENETHYL ANDROSTA 1,4 DIENE 3,17 DIONE; 2 PHENPROPYL ANDROSTA 1,4 DIENE 3,17 DIONE; 2ALPHA BENZYL ANDROSTENEDIONE; 2ALPHA PENTO METHYLPHENETHYL ANDROSTENEDIONE; 2ALPHA PENTO TRIFLUOROMETHYLPHENETHYL ANDROSTENEDIONE; 2ALPHA PHENBUTYL ANDROSTENEDIONE; 2ALPHA PHENETHYL ANDROSTENEDIONE; 2ALPHA PHENPROPYL ANDROSTENEDIONE; ANDROSTENEDIONE; ANDROSTENEDIONE DERIVATIVE; AROMATASE; AROMATASE INHIBITOR; CYSTEINE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANDROSTADIENES; ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITORS; CATALYTIC DOMAIN; ENZYME ACTIVATION; HUMANS; KINETICS; MODELS, MOLECULAR; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 77949264904     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2010.01.008     Document Type: Article

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