Studies directed towards a mechanistic evaluation of inactivation of aromatase by the suicide substrates androsta-1,4-diene-3,17-diones and its 6-ene derivatives. Aromatase inactivation by the 19-substituted derivatives and their enzymic aromatization

Journal of Steroid Biochemistry and Molecular Biology

Volumn 107, Issue 3-5, 2007, Pages 211-219

  Numazawa, Mitsuteru ^a   Nagaoka, Masao ^a   Handa, Wakako ^a   Ogawa, Yoko ^a   Matsuoka, Satomi ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

19 Substituted androsta 1,4 diene 3,17 dione; Aromatase inhibitor; Aromatization; Gas chromatography mass spectrometry; Structure activity relationship; Time dependent inactivation

Indexed keywords

19 METHYL 3BETA HYDROXYANDROST 5 EN 17 ONE; 19 METHYLANDROST 4 ENE 3,17 DIONE; 19 METHYLANDROST 4 ENE 3,6,17 TRIONE; ANDROSTENEDIONE DERIVATIVE; AROMATASE; BOLDIONE; ESTRADIOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INACTIVATION; ENZYME INHIBITION; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; OXYGENATION; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANDROSTADIENES; AROMATASE INHIBITORS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; SUBSTRATE SPECIFICITY;

EID: 34548502695     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2007.03.042     Document Type: Article

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