Improving the design and analysis of animal experiments: A personal odyssey

Alternatives to Laboratory Animals

Volumn 37, Issue SUPPL. 2, 2009, Pages 75-81

  Festing, Michael F W ^a  

^a Understanding Animal Research   (United Kingdom)

Author keywords

Experimental design; FRAME; Inbred strains; Laboratory Animals Centre; Mice; Outbred stocks; Rats; Reduction; Russell and burch; Statistics; Toxicity testing

Indexed keywords

ACADEMIC ACHIEVEMENT; AGRICULTURE; ANIMAL EXPERIMENT; CAREER; DISEASE CONTROL; EXPERIMENTAL ANIMAL; EXPERIMENTAL DESIGN; MEDICAL RESEARCH; MOUSE STRAIN; PRIORITY JOURNAL; QUANTITATIVE GENETICS; RAT STRAIN; REVIEW; TOXICITY TESTING;

ANIMALIA; MUS; RATTUS;

EID: 77749345861     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290903702s06     Document Type: Review

References (25)

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2. Festing, M.F.W. & Nordskog, A.W. (1967). Responses to selection for body weight and egg weight in chickens. Genetics 55, 219-231.
3. Festing, M.F.W. (1979). Inbred Strains in Biomedical Research, 483pp. London, UK: Macmillan.
4. Bradley, D.J. & Kirkley, J. (1977). Regulation of Leishmania populations within the host. I: Genetic control of acute susceptibility of mice to Leishmania donovani infection. Clinical & Experimental Immunology 30, 119-129.
5. Bradley, D.J. (1977). Regulation of Leishmania populations within the host. II: Genetic control of acute susceptibility of mice to Leishmania donovani infection. Clinical & Experimental Immunology 30, 130-140.
6. Bradley, D.J., Taylor, B.A., Blackwell, J., Evans, E.P. & Freeman, J. (1979). Regulation of Leishmania populations within the host. III: Mapping the locus controlling susceptibilty to visceral leishmaniasis in the mouse. Clinical & Experimental Immunology 37, 7-14.
7. Blackwell, J.M., Searle, S., Mohamed, H. & White, J.K. (2003). Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story. Immunology Letters 85, 197-203.
8. Festing, M.F.W. & Fisher, E.M.C. (2000). Mighty mice. Nature, London 404, 815.
9. Festing, M.F.W. & King, D. (1974). Large-scale production of nude mice. In Workshop on Nude Mice (ed. J. Rygaard & CO. Povlsen), pp. 203-205. Stuttgart, Germany: Gustav Fischer.
10. Festing, M.F.W., May, D., Connors, T.A., Lovell, D.P. & Sparrow, S. (1978). An athymic mutation in the rat. Nature, London 274, 365-366.
11. Grüneberg, H. (1952). The Genetics of the Mouse. Second Edition, 650pp. The Hague, The Netherlands: Martinus Nijhoff.
12. Festing, M.F.W. (1972). Mouse strain identification. Nature, London 238, 351-352.
13. Festing, M.F.W. (1974). The genetic reliability of commercially bred laboratory mice. Laboratory Animals 8, 265-270.
14. Yang, A.L. & Festing, M.F. (2001). A promoter function of the CCCGGG Sma I recognition sequence and its specific role in determining p53 status and identifying DNA damaging agents. Biochemical & Biophysical Research Communications 281, 506-510.
15. Lovell, D.P. & Festing, M.F.W. (1982). Relationships among colonies of the laboratory rat. Journal of Heredity 73, 81-82.
16. Festing, M.F.W., Baumans, V., Combes, R.D., Haider, M., Hendriksen, C.F.M., Howard, B.R., Lovell, D.P., Moore, G.J., Overend, P. & Wilson, M.S. (1998). Reducing the use of laboratory animals in biomedical research: problems and possible solutions. ATLA 26, 283-301.
17. Balls, M., Festing, M.F.W. & Vaughan, S. (2004). Reducing the use of experimental animals where no replacement is yet available. ATLA 32, 1-104.
18. Hudson, M. & Howard, B. (2009). The FRAME Reduction Steering Committee: reflections on a decade devoted to reducing animal use in biomedical science. ATLA 37, 23-26.
19. Howard, B., Hudson, M. & Preziosi, R. (2009). More is less: reducing animal use by raising awareness of the principles of efficient study design and analysis. ATLA 37, 33-42.
20. Festing, M.F.W., Overend, P., Gaines Das, R., Cortina Borja, M. & Berdoy, M. (2002). The Design of Animal Experiments, 112pp. London, UK: Laboratory Animals Ltd.
21. Festing, M.F.W. (2002). Introduction: The design and statistical analysis of animal experiments. ILAR Journal 43, 191-193.
22. Festing, M.F.W. (1996). Are animal experiments in toxicological research the "right" size? In Statistics in Toxicology (ed. B.J.T. Morgan), pp. 3-11. Oxford, UK: Clarendon Press.
23. Festing, M.F.W. (1975). A case for using inbred strains of laboratory animals in evaluating the safety of drugs. Food & Cosmetics Toxicology 13, 369-375.
24. Festing, M.F.W. (1986). The case for isogenic strains in toxicological screening. Archives of Toxicology. Supplement 9, 127-137.
25. Festing, M.F.W. (1995). Use of a multi-strain assay could improve the NTP carcinogenesis bioassay program. Environmental Health Perspectives 103, 44-52.