PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans: A study of 10 cases

Clinical and Experimental Dermatology

Volumn 35, Issue 3, 2010, Pages 295-299

  Muchemwa, F C ^a   Wakasugi, S ^a   Honda, Y ^a   Ihn, H ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA1; COMPLEMENTARY DNA; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR B; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; DERMATOFIBROMA; DERMATOFIBROSARCOMA PROTUBERANS; DNA SEQUENCE; EXON; FEMALE; FROZEN SECTION; FUSION GENE; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; SEQUENCE ANALYSIS;

ADULT; CHILD; CHROMOSOME MAPPING; COLLAGEN TYPE I; DERMATOFIBROSARCOMA; FEMALE; HUMANS; MALE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; PLATELET-DERIVED GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; STATISTICS AS TOPIC; TUMOR MARKERS, BIOLOGICAL;

EID: 77749344561     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2009.03474.x     Document Type: Article

References (17)

1. Simon M, Pedeutour F, Sirvent N et al. Deregulation of the platelet derived growth factor B-chain gene via fusion with the COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nature Genet 1997 15 : 95 9.
2. Sirvent N, Maire G, Pedeutour F. Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer 2003 37 : 1 19.
3. Vuorio E, de Crombrugghe B. The family of collagen genes. Annu Rev Biochem 1990 59 : 837 872.
4. Greco A, Fusetti L, Villa R et al. Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans. Oncogene 1998 17 : 1313 1319.
5. Shimizu A, O'Brien K, Sjöblom T et al. The dermatofibrosarcoma protuberans - associated collagen type 1α1/platelete derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res 1999 59 : 3719 3723.
6. Simon MP, Navarro M, Roux D et al. Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t (17; 22) (q22; q13.1) in dermatofibrosarcoma protuberans. Oncogene 2001 20 : 2965 2975.
7. Wang J, Hisaoka M, Shimajiri S et al. Detection of COL1A1-PDGFB fusion transcripts in dermatofibrosarcoma protuberans by reverse transcription- polymerase chain reaction using archival formalin-fixed, paraffin-embedded tissues. Diagn Mol Pathol 1999 8 : 113 119. (Pubitemid 29521901)
8. Lindner NJ, Scarborough MT, Powell GJ et al. Revision surgery in dermatofibrosarcoma protuberans of the trunk and extremities. Eur J Surg Oncol 1999 25 : 392 397.
9. Do AN, Goleno K, Geisse JK. Mohs micrographic surgery and partial amputation preserving function and aesthetics in digits: case reports of invasive melanoma and digital dermatofibrosarcoma protuberans. Dermatol Surg 2006 32 : 1516 1521.
10. Snow SN, Gordon ME, Larson PO et al. Dermatofibrosarcoma protuberans. A report of 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature. Cancer 2004 101 : 28 38.
11. Sun LM, Wang CJ, Huang CC et al. Dermatofibrosarcoma protuberans: treatment results of 35 cases. Radiother Oncol 2000 57 : 175 181.
12. McAuthur G. Molecularly targeted treatment for dermatofibrosarcoma protuberans. Semin Oncol 2004 31 : 30 6.
13. Kasper B, Lossignol D, Gil T et al. Imatinib mesylate in a patient with metastatic disease originating from a dermatofibrosarcoma protuberans of the scalp. Anticancer Drugs 2006 17 : 1223 1225.
14. Rubin BP, Schuetze SM, Eary JF et al. Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 2002 20 : 3586 3591.
15. Mizutani K, Tamada Y, Hara K et al. Imatinib mesylate inhibits the growth of metastatic lung lesions in a patient with dermatofibrosarcoma protuberans. Br J Dermatol 2004 151 : 235 237.
16. O'Brien KP, Seroussi E, Dal Cin P et al. Various regions within the α-helical domain of the COL1A1 gene are fused with second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastoma. Genes Chromosomes Cancer 1998 23 : 187 193.
17. Takahira T, Oda Y, Tamiya S et al. Detection of COL1A1-PDGFB fusion transcripts and PDGF/PDGFRB mRNA expression in dermatofibrosarcoma protuberans. Modern Pathol 2007 20 : 668 675.