Acute and chronic effects of endotoxin on cerebral circulation in lambs

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 298, Issue 3, 2010, Pages

  Feng, Susan Y S ^a   Samarasinghe, Thilini ^a   Phillips, David J ^a   Alexiou, Theodora ^a   Hollis, Jacob H ^a   Yu, Victor Y H ^a,b   Walker, Adrian M ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

Author keywords

Cerebral blood flow; Cerebral endothelial function

Indexed keywords

BRADYKININ; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN INJURY; BRAIN PERFUSION; BRAIN VASCULAR RESISTANCE; CHRONIC TOXICITY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTOXEMIA; HISTOPATHOLOGY; LAMB; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; VASOCONSTRICTION;

ACUTE DISEASE; ANIMALS; ANIMALS, NEWBORN; BODY TEMPERATURE; BRADYKININ; BRAIN; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ENDOTHELIUM, VASCULAR; ENDOTOXEMIA; LIPOPOLYSACCHARIDES; MACROPHAGES; NITRATES; NITRITES; SHEEP; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR RESISTANCE; VASODILATION; VASODILATOR AGENTS;

EID: 77749326692     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00398.2009     Document Type: Article

References (45)

1. Brian JE Jr, Faraci FM. Tumor necrosis factor-alpha-induced dilatation of cerebral arterioles. Stroke 29: 509-515, 1998.
2. Coumans AB, Garnier Y, Supcun S, Jensen A, Berger R, Hasaart TH. Nitric oxide and fetal organ blood flow during normoxia and hypoxemia in endotoxin-treated fetal sheep. Obstet Gynecol 105: 145-155, 2005.
3. Dalitz P, Harding R, Rees SM, Cock ML. Prolonged reductions in placental blood flow and cerebral oxygen delivery in preterm fetal sheep exposed to endotoxin: possible factors in white matter injury after acute infection. J Soc Gynecol Investig 10: 283-290, 2003.
4. Didion SP, Faraci FM. Angiotensin II produces superoxide-mediated impairment of endothelial function in cerebral arterioles. Stroke 34: 2038-2042, 2003.
5. Duncan JR, Cock ML, Scheerlinck JP, Westcott KT, McLean C, Harding R, Rees SM. White matter injury after repeated endotoxin exposure in the preterm ovine fetus. Pediatr Res 52: 941-949, 2002.
6. Duncan JR, Cock ML, Suzuki K, Scheerlinck JP, Harding R, Rees SM. Chronic endotoxin exposure causes brain injury in the ovine fetus in the absence of hypoxemia. J Soc Gynecol Investig 13: 87-96, 2006.
7. Eklind S, Mallard C, Leverin AL, Gilland E, Blomgren K, Mattsby-Baltzer I, Hagberg H. Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury. Eur J Neurosci 13: 1101-1106, 2001.
8. Ekstrom-Jodal B, Elfverson J, Larsson LE. Early effects of E. coli endotoxin on superior sagittal sinus blood flow An experimental study in dogs. Acta Anaesthesiol Scand 26: 171-174, 1982.
9. Feng SY, Phillips DJ, Stockx EM, Yu VY, Walker AM. Endotoxin has acute and chronic effects on the cerebral circulation of fetal sheep. Am J Physiol Regul Integr Comp Physiol 296: R640-R650, 2009.
10. Gorlach C, Wahl M. Bradykinin dilates rat middle cerebral artery and its large branches via endothelial B2 receptors and release of nitric oxide. Peptides 17: 1373-1378, 1996.
11. Grant DA, Franzini C, Wild J, Walker AM. Continuous measurement of blood flow in the superior sagittal sinus of the lamb. Am J Physiol Regul Integr Comp Physiol 269: R274-R279, 1995.
12. Greisen G. Cerebral blood flow and energy metabolism in the newborn. Clin Perinatol 24: 531-546, 1997.
13. Greisman SE, Young EJ, Carozza FA Jr. Mechanisms of endotoxin tolerance. V. Specificity of the early and late phases of pyrogenic tolerance. J Immunol 103: 1223-1236, 1969.
14. Hagberg H, Peebles D, Mallard C. Models of white matter injury: comparison of infectious, hypoxic-ischemic, and excitotoxic insults. Ment Retard Dev Disabil Res Rev 8: 30-38, 2002.
15. Hamilton GS, Edwards B, Solin P, Walker AM. A model of coronary artery endothelial dysfunction in the sleeping lamb. Sleep Med 7: 573-579, 2006.
16. Hernanz R, Alonso MJ, Briones AM, Vila E, Simonsen U, Salaices M. Mechanisms involved in the early increase of serotonin contraction evoked by endotoxin in rat middle cerebral arteries. Br J Pharmacol 140: 671-680, 2003.
17. Hutton LC, Castillo-Melendez M, Smythe GA, Walker DW. Microglial activation, macrophage infiltration, and evidence of cell death in the fetal brain after uteroplacental administration of lipopolysaccharide in sheep in late gestation. Am J Obstet Gynecol 198: 117.e1-11, 2008.
18. Johnson J, Sudheimer K, Davis K, Kernd G, Winn B. The Sheep Brain Atlas. https://www.msu.edu/~brains/brains/sheep/index.html, 2008.
19. Jones B, Peake K, Morris AJ, McCowan LM, Battin MR. Escherichia coli: a growing problem in early onset neonatal sepsis. Aust N Z J Obstet Gynaecol 44: 558-561, 2004.
20. Jones MD Jr, Traystman RJ. Cerebral oxygenation of the fetus, newborn, and adult. Semin Perinatol 8: 205-216, 1984.
21. Kluger MJ. Fever: role of pyrogens and cryogens. Physiol Rev 71: 93-127, 1991.
22. Leclerc J, Pu Q, Corseaux D, Haddad E, Decoene C, Bordet R, Six I, Jude B, Vallet B. A single endotoxin injection in the rabbit causes prolonged blood vessel dysfunction and a procoagulant state. Crit Care Med 28: 3672-3678, 2000.
23. Lin NT, Yang FL, Lee RP, Peng TC, Chen HI. Inducible nitric oxide synthase mediates cytokine release: the time course in conscious and septic rats. Life Sci 78: 1038-1043, 2006.
24. Lip GY, Blann A. Von Willebrand factor: a marker of endothelial dysfunction in vascular disorders? Cardiovasc Res 34: 255-265, 1997.
25. Maekawa T, Fujii Y, Sadamitsu D, Yokota K, Soejima Y, Ishikawa T, Miyauchi Y, Takeshita H. Cerebral circulation and metabolism in patients with septic encephalopathy. Am J Emerg Med 9: 139-143, 1991.
26. Mallard C, Welin AK, Peebles D, Hagberg H, Kjellmer I. White matter injury following systemic endotoxemia or asphyxia in the fetal sheep. Neurochem Res 28: 215-223, 2003.
27. McClure L, O'Connor AE, Hayward S, Jenkin G, Walker DW, Phillips DJ. Effects of age and pregnancy on the circulatory activin response of sheep to acute inflammatory challenge by lipopolysaccharide. J Endocrinol 185: 139-149, 2005.
28. Mengozzi M, Fantuzzi G, Sironi M, Bianchi M, Fratelli M, Peri G, Bernasconi S, Ghezzi P. Early down-regulation of TNF production by LPS tolerance in human monocytes: comparison with IL-1 beta, IL-6, and IL-8. Lymphokine Cytokine Res 12: 231-236, 1993.
29. Minc-Golomb D, Tsarfaty I, Schwartz JP. Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine. Br J Pharmacol 112: 720-722, 1994.
30. Okamoto H, Ito O, Roman RJ, Hudetz AG. Role of inducible nitric oxide synthase and cyclooxygenase-2 in endotoxin-induced cerebral hyperemia. Stroke 29: 1209-1218, 1998.
31. Parker JL, Emerson TE Jr. Cerebral hemodynamics, vascular reactivity, and metabolism during canine endotoxin shock. Circ Shock 4: 41-53, 1977.
32. Peebles DM, Miller S, Newman JP, Scott R, Hanson MA. The effect of systemic administration of lipopolysaccharide on cerebral haemodynamics and oxygenation in the 0.65 gestation ovine fetus in utero. BJOG 110: 735-743, 2003.
33. Rummel C, Sachot C, Poole S, Luheshi GN. Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain. Am J Physiol Regul Integr Comp Physiol 291: R1316-R1326, 2006.
34. Sibson NR, Blamire AM, Perry VH, Gauldie J, Styles P, Anthony DC. TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway. Brain 125: 2446-2459, 2002.
35. Skopal J, Turbucz P, Vastag M, Bori Z, Pek M, deChatel R, Nagy Z, Toth M, Karadi I. Regulation of endothelin release from human brain microvessel endothelial cells. J Cardiovasc Pharmacol 31, Suppl 1: S370-S372, 1998.
36. Soul JS, Hammer PE, Tsuji M, Saul JP, Bassan H, Limperopoulos C, Disalvo DN, Moore M, Akins P, Ringer S, Volpe JJ, Trachtenberg F, du Plessis AJ. Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatr Res 61: 467-473, 2007.
37. Ueno M, Lee TJ. Endotoxin decreases the contractile responses of the porcine basilar artery to vasoactive substances. J Cereb Blood Flow Metab 13: 712-719, 1993.
38. Volpe JJ. Cerebral white matter injury of the premature infant-more common than you think. Pediatrics 112: 176-180, 2003.
39. Wang X, Hagberg H, Nie C, Zhu C, Ikeda T, Mallard C. Dual role of intrauterine immune challenge on neonatal and adult brain vulnerability to hypoxia-ischemia. J Neuropathol Exp Neurol 66: 552-561, 2007.
40. Wang X, Rousset CI, Hagberg H, Mallard C. Lipopolysaccharide- induced inflammation and perinatal brain injury. Semin Fetal Neonatal Med 11: 343-353, 2006.
41. Whyte RI, Warren HS, Greene E, Glennon ML, Robinson DR, Zapol WM. Tolerance to low-dose endotoxin in awake sheep. J Appl Physiol 66: 2546-2552, 1989.
42. Wu YW, Escobar GJ, Grether JK, Croen LA, Greene JD, Newman TB. Chorioamnionitis and cerebral palsy in term and near-term infants. JAMA 290: 2677-2684, 2003.
43. Yanowitz TD, Baker RW, Roberts JM, Brozanski BS. Low blood pressure among very-low-birth-weight infants with fetal vessel inflammation. J Perinatol 24: 299-304, 2004.
44. Young RS, Hernandez MJ, Yagel SK. Selective reduction of blood flow to white matter during hypotension in newborn dogs: a possible mechanism of periventricular leukomalacia. Ann Neurol 12: 445-448, 1982.
45. Zoccoli G, Grant DA, Wild J, Walker AM. Nitric oxide inhibition abolishes sleep-wake differences in cerebral circulation. Am J Physiol Heart Circ Physiol 280: H2598-H2606, 2001.