Mucociliary transport determined by in vivo microdialysis in the airways of normal and CF mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 286, Issue 3 30-3, 2004, Pages

  Grubb, B R ^a   Jones, J H ^b   Boucher, R C ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cystic fibrosis; In vivo microdialysis; Nasal cavity; Trachea

Indexed keywords

ATROPINE; DYE; PILOCARPINE; RHODAMINE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CYSTIC FIBROSIS; DIALYSIS MEMBRANE; FROG; MICRODIALYSIS; MOUSE; MUCOCILIARY TRANSPORT; NONHUMAN; NOSE CAVITY; PALATE; PRIORITY JOURNAL; TRACHEA;

EID: 1242284470     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00302.2003     Document Type: Article

References (39)

1. Afzelius BA. A human syndrome caused by immotile cilia. Science 193: 317-319, 1976.
2. Ballard ST, Trout L, Mehta A, and Inglis SK. Liquid secretion inhibitors reduce mucociliary transport in glandular airways. Am J Physiol Lung Cell Mol Physiol 283: L329-L335, 2002.
3. Brownstein DG. Tracheal mucociliary transport in laboratory mice: evidence for genetic polymorphism. Exp Lung Res 13: 185-191, 1987.
4. Chopra SK. Effect of atropine on mucociliary transport velocity in anesthetized dogs. Am Rev Respir Dis 118: 367-371, 1978.
5. Cowley EA, Wang CG, Gosselin D, Radzioch D, and Eidelman DH. Mucociliary clearance in cystic fibrosis knockout mice infected with Pseudomonas aeruginosa. Eur Respir J 10: 2312-2318, 1997.
6. Felicetti SA, Wolff RK, and Muggenburg BA. Comparison of tracheal mucous transport in rats, guinea pigs, rabbits, and dogs. J Appl Physiol 51: 1612-1617, 1981.
7. Festa E, Guimaraes E, Macchione M, Saldiva PHN, and King M. Acute effects of uridine 5′-triphosphate on mucociliary clearance in isolated frog palate. J Aerosol Med 10: 25-39, 1997.
8. Foster WM, Walters DM, Longphre M, Macri K, and Miller LM. Methodology for the measurement of mucociliary function in the mouse by scintigraphy. J Appl Physiol 90: 1111-1117, 2001.
9. Ganz T. Antimicrobial polypeptides in host defense of the respiratory tract. J Clin Invest 109: 693-697, 2002.
10. Gatto LA. Cholinergic and adrenergic stimulation of mucociliary transport in the rat trachea. Respir Physiol 92: 209-217, 1993.
11. Gehr P, Geiser M, Im Hof V, Schuerch S, and Cruz-Orive LM. Stereological estimation of particle retention and clearance in the intrapulmonary conducting airways of the hamster lungs. J Aerosol Sci 21: 362-368, 1990.
12. Grubb BR and Boucher RC. Pathophysiology of gene-targeted mouse models for cystic fibrosis. Physiol Rev 79: S193-S214, 1999.
13. Grubb BR, Chadburn JL, and Boucher RC. In vivo microdialysis for the determination of ariway surface liquid ion composition. Am J Physiol Cell Physiol 282: C1423-C1431, 2002.
14. Grubb BR, Paradiso AM, and Boucher RC. Anomalies in ion transport in CF mouse tracheal epithelium. Am J Physiol Cell Physiol 267: C293-C300, 1994.
15. - secretion in nasal epithelia of CF mice. Am J Physiol Cell Physiol 266: C1478-C1483, 1994.
16. Ibanez-Tallon I, Gorokhova S, and Heintz N. Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus. Hum Mol Genet 11: 715-721, 2002.
17. Knowles M, Gatzy J, and Boucher R. Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis. N Engl J Med 305: 1489-1495, 1981.
18. Kobayashi Y, Watanabe M, Okada Y, Sawa H, Takai H, Nakanishi M, Kawase Y, Suzuki H, Nagashima K, Ikeda K, and Motoyama N. Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome. Mol Cell Biol 22: 2769-2776, 2002.
19. Kurosawa H, Wang CG, Dandurand RJ, King M, and Eidelman DH. Mucociliary function in the mouse measured in explanted lung tissue. J Appl Physiol 79: 41-46, 1995.
20. Lippmann M, Albert RE, Yeates DB, Berger JM, Foster WM, and Bohning DE. Factors affecting tracheobronchial mucociliary transport. Inhaled Part 1: 305-319, 1975.
21. Look DC, Walter MJ, Williamson MR, Pang L, You Y, Sreshta JN, Johnson JE, Zander DS, and Brody SL. Effects of paramyxoviral infection on airway epithelial cell Foxjl expression, ciliogenesis, and mucociliary function. Am J Pathol 159: 2055-2069, 2001.
22. Mall M. Overexpression of ENaC in mouse airways: a novel animal model for chronic bronchitis and cystic fibrosis lung disease (Abstract). Pediatr Pulmonol Suppl 25: 121, 2003.
23. Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, and Boucher RC. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95: 1005-1015, 1998.
24. Morgan KT, Jiang XZ, Patterson DL, and Gross EA. The nasal mucociliary apparatus. Correlation of structure and function in the rat. Am Rev Respir Dis 130: 275-281, 1984.
25. Neesen J, Kirschner R, Ochs M, Schmiedl A, Habermann B, Mueller C, Holstein AF, Nuesslein T, Adham I, and Engel W. Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency. Hum Mol Genet 10: 1117-1128, 2001.
26. Palmblad J, Mossberg B, and Afzelius BA. Ultrastructural, cellular, and clinical features of the immotile-cilia syndrome. Annu Rev Med 35: 481-492, 1984.
27. Parmley RR and Gendler SJ. Cystic fibrosis mice lacking Mucl have reduced amounts of intestinal mucus. J Clin Invest 102: 1798-1806, 1998.
28. Phipps RJ. The airway mucociliary system. Int Rev Physiol 23: 213-260, 1981.
29. Regnis JA, Robinson M, Bailey DL, Cook P, Hooper P, Chan HK, Gonda I, Bautovich G, and Bye PT, Mucociliary clearance in patients with cystic fibrosis and in normal subjects. Am J Respir Crit Care Med 150: 66-71, 1994.
30. Robinson M and Bye PTB. Mucociliary clearance in cystic fibrosis. Pediatr Pulmonol 33: 293-306, 2002.
31. Rubin BK, Ramirez O, and King M. Mucus-depleted frog palate as a model for the study of mucociliary clearance. J Appl Physiol 69: 424-429, 1990.
32. Rutland J and Cole PJ. Nasal mucociliary clearance and ciliary beat frequency in cystic fibrosis compared with sinusitis and bronchiectasis. Thorax 36: 654-658, 1981.
33. Smith JJ, Travis SM, Greenberg EP, and Welsh MJ. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85: 229-236, 1996.
34. Snouwaert JN, Brigman KK, Latour AM, Malouf NN, Boucher RC, Smithies O, and Koller BH. An animal model for cystic fibrosis made by gene targeting. Science 257: 1083-1088, 1992.
35. Takeuchi K, Suzumura E, Majima Y, and Sakakura Y. Effect of atropine on nasal mucociliary clearance. Acta Otolaryngol 110: 120-123, 1990.
36. Tarran R, Grubb BR, Parsons D, Picher M, Hirsh AJ, Davis CW, and Boucher RC. The CF salt controversy: in vivo observations and therapeutic approaches. Mol Cell 8: 149-158, 2001.
37. Tomkiewicz RP, Albers GM, De Sanctis GT, Ramirez OE, King M, and Rubin BK. Species differences in the physical and transport properties of airway secretions. Can J Physiol Pharmacol 73: 165-171, 1995.
38. Wanner A. Effect of ipratropium bromide on airway mucociliary function. Am J Med 81: 23-27, 2003.
39. Zahm JM, Gaillard D, Dupuit F, Hinnrasky J, Porteous D, Dorin JR, and Puchelle E. Early alterations in airway mucociliary clearance and inflammation of the lamina propria in CF mice. Am J Physiol Cell Physiol 272: C853-C859, 1997.