Hypokalemia following polyethylene glycol-based bowel preparation for colonoscopy in older hospitalized patients with significant comorbidities

Annals of Pharmacotherapy

Volumn 44, Issue 3, 2010, Pages 466-470

  Ho, Joanne Man Wai ^a,c   Juurlink, David Nelson ^b,c,d,e   Cavalcanti, Rodrigo Brandao ^a,f  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^e Ontario Poison Centre   (Canada)

^f TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Colonoscopy; Older patients; Polyethylene glycol based bowel preparation; Risk; Water and electrolyte imbalance

Indexed keywords

CREATININE; DIGESTIVE TRACT AGENT; DIURETIC AGENT; LOOP DIURETIC AGENT; POLYETHYLENE GLYCOL BASED BOWEL PREPARATION; POTASSIUM; POTASSIUM SPARING DIURETIC AGENT; THIAZIDE DIURETIC AGENT; UNCLASSIFIED DRUG;

AGED; AGED HOSPITAL PATIENT; ARTICLE; BRONCHIECTASIS; CELLULITIS; CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY; COLONOSCOPY; COMORBIDITY; CONGESTIVE HEART FAILURE; CORONARY ARTERY DISEASE; CREATININE BLOOD LEVEL; FALLING; FEMALE; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART DISEASE; HEART INFARCTION; HUMAN; HYPOKALEMIA; INCIDENCE; KIDNEY DISEASE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PNEUMONIA; POTASSIUM BLOOD LEVEL; POTASSIUM INTAKE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SYNCOPE; URINARY TRACT INFECTION;

AGED; AGED, 80 AND OVER; CATHARTICS; COLONOSCOPY; COMORBIDITY; FEMALE; HUMANS; HYPOKALEMIA; INPATIENTS; MALE; ONTARIO; POLYETHYLENE GLYCOLS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 77749314372     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1M341     Document Type: Article

References (26)

1. Schultz SE, Vinden C, Rabeneck L. Colonoscopy and flexible sigmoidoscopy practice patterns in Ontario: a population-based study. Can J Gastroenterol 2007;21:431-4.
2. Vinden C, Schultz SE, Rabeneck L. ICES Research Atlas: use of large bowel procedures in Ontario, February 2004.
3. Lagares-Garcia JA, Kurek S, Collier B, et al. Colonoscopy in octogenarians and older patients. Surg Endosc 2001;15:262-5.
4. Mathus-Vliegen EM, Kemble UM. A prospective randomized blinded comparison of sodium phosphate and polyethylene glycol-electrolyte solution for safe bowel cleansing. Aliment Pharmacol Ther 2006;23:543-52.
5. Ell C, Fischbach W, Keller R, et al. A randomized, blinded, prospective trial to compare the safety and efficacy of three bowel-cleansing solutions for colonoscopy (HSG-01*). Endoscopy 2003;35:300-4.
6. Seinela L, Pehkonen E, Laasanen T, et al. Bowel preparation for colonoscopy in very old patients: a randomized prospective trial comparing oral sodium phosphate and polyethylene glycol electrolyte lavage solution. Scand J Gastroenterol 2003;38:216-20.
7. Alert FDA. Oral sodium phosphate (OSP) products for bowel cleansing. December 11, 2008.
8. Ayus JC, Levine R, Arieff AI. Fatal dysnatraemia caused by elective colonoscopy. BMJ 2003;326:382-4.
9. Cohen SM, Wexner SD, Binderow SR, et al. Prospective, randomized, endoscopic-blinded trial comparing precolonoscopy bowel cleansing methods. Dis Colon Rectum 1994;37:689-96.
10. Ho JM, Cavalcanti RB. A shocking bowel prep: severe electrolyte disturbances following polyethylene glycol-based bowel preparation. J Am Geriatr Soc 2009;57:1729-30.
11. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999;130:461-70.
12. Davis GR, Santa Ana CA, Morawski SG, et al. Development of a lavage solution associated with minimal water and electrolyte absorption or secretion. Gastroenterology 1980;78:991-5.
13. Tenenbein M, Cohen S, Sitar DS. Whole bowel irrigation as a decontamination procedure after acute drug overdose. Arch Intern Med 1987;147:905-7.
14. Smith SW, Ling LJ, Halstenson CE. Whole-bowel irrigation as a treatment for acute lithium overdose. Ann Emerg Med 1991;20:536-9.
15. Task Force from The American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). A consensus document on bowel preparation before colonoscopy. Gastrointest Endosc 2006;63:894-906.
16. Hwang KL, Chen WT, Hsiao KH, et al. Prospective randomized comparison of oral sodium phosphate and polyethylene glycol lavage for colonoscopy preparation. World J Gastroenterol 2005;11:7486-93.
17. Russmann S, Lamerato L, Marfatia A, et al. Risk of impaired renal function after colonoscopy: a cohort study in patients receiving either oral sodium phosphate or polyethylene glycol. Am J Gastroenterol 2007;102:2655-63.
18. Marschall HU, Bartels F. Life-threatening complications of nasogastric administration of polyethylene glycol-electrolyte solutions (Golytely) for bowel cleansing. Gastrointest Endosc 1998;47:408-10.
19. van Dinter TG, Fuerst FC, Richardson CT, et al. Stimulated active potassium secretion in a patient with colonic pseudo-obstruction: a new mechanism of secretory diarrhea. Gastroenterology 2005;129:1268-73.
20. Mall M, Wissner A, Seydewitz HH, et al. Defective cholinergic Cl-secretion and detection of K+ secretion in rectal biopsies from cystic fibrosis patients. Am J Physiol Gastrointest Liver Physiol 2000;278:617-24.
21. Schulzke JD, Riecken EO, Fromm M. Distension-induced electrogenic Cl-secretion is mediated via VIP-ergic neurons in rat rectal colon. Am J Physiol Gastrointest Liver Physiol 1995;268:725-31.
22. Frieling T, Wood JD, Cooke HJ. Submucosal reflexes: distension-evoked ion transport in the guinea pig distal colon. Am J Physiol Gastrointest Liver Physiol 1992;263:91-6.
23. Martin RS, Panese S, Virginillo M, et al. Increased secretion of potassium in the rectum of humans with chronic renal failure. Am J Kidney Dis 1986;8:105-10.
24. Hirsch D, Pace P, Binder HJ, et al. Evidence that aldosterone influences transport in target tissues by dissimilar mechanisms. Am J Physiol Renal Physiol 1985;248:507-12.
25. Epstein M. Aging and the kidney. J Am Soc Nephrol 1996;7:1106-22.
26. Phillips PA, Rolls BJ, Ledingham JG, et al. Reduced thirst after water deprivation in healthy elderly men. N Engl J Med 1984;311:753-9.