Recent advances in the use of Panax ginseng as an analgesic: A systematic review

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

Volumn 8, Issue 3, 2009, Pages 188-194

  Braz, Alessandra De Sousa ^a   Diniz, Margareth De Fátima F Melo ^a   De Almeida, Reinaldo Nóbrega ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Analgesia; Antinociception; Ginseng extract; Ginsenoside

Indexed keywords

GINSENG EXTRACT; GINSENOSIDE; SAPONIN DERIVATIVE;

ANALGESIA; ANALGESIC ACTIVITY; ANTINOCICEPTION; CARDIOVASCULAR DISEASE; CHINA; CLINICAL TRIAL; DEGENERATIVE DISEASE; GINSENG; HERBAL MEDICINE; HUMAN; IMMUNE DEFICIENCY; JAPAN; KOREA; MALIGNANT NEOPLASTIC DISEASE; NOCICEPTION; REVIEW; SYSTEMATIC REVIEW;

PANAX GINSENG;

EID: 77749314330     PISSN: None     EISSN: 07177917     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Attele A, Wu J, Yuan C. 1999. Multiple pharmacological effects of ginseng [commentary]. Biochem Pharmacol 58:1685-1693.
2. Buettner C, Yeh G, Phillips R, Mittleman M, Kaptchuk T. 2006. Systematic review of the effects of ginseng on cardiovascular risk factors. Ann Pharmacother 40:83-95.
3. Choi S, Kim T, Shin Y, Lee C, Park M, Lee H, Song J. 2008. Effects of a polyacetylene from Panax ginseng on Na(+) currents in rat dorsal root ganglion neurons. Brain Res 29(1191):75-83.
4. Choi S, Han E, Han K, Lee H, Suh H. 2003. Antinociceptive effects of ginsenosides injected intracerebroventricularly or intrathecally in substance p-induced pain model. Planta Med 69:1001-1004.
5. Coleman CI, Hebert JH, Reddy P. 2003. The effects of Panax ginseng on quality of life. J Clin Pharm Ther 28:5-15.
6. D'Angelo L, Grimaldi R, Caravaggi M, Marcoli M, Perucca E, Lecchini S, Frigo GM, Crema A. 1986. A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol 16:15-22.
7. Davydov M, Krikorian A. 2000. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J Ethnopharmarmacol 72:345-393.
8. Einat H. 2007. Chronic oral administration of ginseng extract results in behavioral change but has no effects in mice models of affective and anxiety disorders. Phytother Res 21:62-66.
9. Ellis J, Reddy P. 2002. Effects of Panax ginseng on quality of life. Ann Pharmacother 36:375-379.
10. Hahn J, Nah S, Nah J, Uhm D, Chung S. 2000. Ginsenosides inhibit capsaicin-activated channel in rat sensory neurons. Neurosci Lett 287:45-48.
11. Hofseth L, Wargovich M 2007. Inflammation, cancer, and targets of ginseng. J. Nutr. 137: 183S-185S.
12. Hong B, Ji Y, Hong J, Nam K, Ahn T. 2002. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 168:20-21.
13. Kaneko H, Nakanishi K. 2004. Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, korean red ginseng: especifically, its anti-stress action for prevention of disease. J Pharmacol Sci 95:158-162.
14. Kiefer D, Pantuso T. 2003. Panax ginseng. Am Fam Phys 68:1539-1542.
15. Kim SJ, Jeong HJ, Yi BJ, Kang TH, An NH, Lee EH, Yang DC, Kim HM, Hong SH, Um JY. 2007. Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. Am. J. Chin. Med. 35: 329-339.
16. Kim Y, Kim S, Markelonis G, Oh T. 1998. Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. J Neurosci Res 54:123.
17. Leung KW, Yung KK, Mak NK, Yue PY, Luo HB, Cheng YK, Fan TP, Yeung HW, Ng TB, Wong RN. 2007. Angiomodulatory and neurological effects of ginsenosides. Curr Med Chem 14:1371-1380.
18. Liao B, Newmark H, Zhou R. 2002. Neuroprotective effects of ginseng total saponin qand ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro. Exp Neurol 173:224-234.
19. Li S, Chu Y. 1997. Anti-inflammatory effects of total saponins of Panax notoginseng. Pharmacol Biochem Behav 57:285-291.
20. Mannaa F, Abdel-Wahhab M, Ahmed H, Park M. 2006. Protective role of Panax ginseng extract standardized with ginsenoside Rg3 against acrylamide-induced neurotoxicity in rats. J Appl Toxicol 26:198-206.
21. McElhaney J, Gravenstein S, Cole S, Davidson E, O'neill D, Petitjean S, Rumble B, Shan JJ. 2004. A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-EOO2) to prevent acute respiratory illness in institutionalized older adults. J Am Geriatr Soc 52:13-19.
22. Mogil J, Shin Y, Mccleskey E, Kim S, Nah S. 1998. Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice. Brain Res 792:218-228.
23. Nah J, Hahn J, Chung S, Choi S, Kim Y, Nah S. 2000. Effect of ginsenosides, active components of ginseng, on capsaicin-induced pain-related behavior. Neuropharmacol 39:2180-2184.
24. Nah S, Mccleskey E. 1994. Ginseng root extract inhibits calcium channels in rat sensory neurons through a similar path, but different receptor, as mu-type opioids. J Ethnopharmacol 42:45-51.
25. Nemmani k, Ramarao P. 2003. Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice. Life Sci 72:759-768.
26. Park EK, Shin YW, Lee HU, Kim SS, Lee YC, Lee BY, Kim DH. 2005. Inhibitory effect of ginsenoside Rb1 and compound K on NO prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide. Biol Pharm Bull 28:652-656.
27. Panwar M, Kumar M, Samarth R, Kumar A. 2005. Evaluation of chemopreventive action and antimutagenic effect of the standardized Panax ginseng extract, EFLA400, in Swiss albino mice. Phytother Res 19:65-71.
28. Radad K, Gille G, Liu L, Rausch W. 2006. Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci 100:175-186.
29. Ramarao P, Bhargava H. 1990. Antagonism of the acute pharmacological actions of morphine by Panax ginseng extract. Gen Pharmacol 21:877-880.
30. Rege N, Thatte U, Dahanukar S. 1999. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 13:275-291.
31. Rhim H, Kim H, Lee D, Oh T, Nah S. 2002. Ginseng and ginsenoside Rg3, a newly identified active ingredient of ginseng, modulate Ca2+ channel currents in rat sensory neurons. Eur J Pharmacol 436:151-158.
32. Sampson J, Phillipson J, Bowery N, O'Neill M, Houston J, Lewis J. 2000. Ethnomedicinally selected plants as sources of potential analgesic compounds: indication of in vitro biological activity in receptor binding assays. Phytother Res 14:24-29.
33. Shin Y, Jung O, Nah J, Nam K, Kim C, Nah S. 1999. Ginsenosides that produce differential antinociception in mice. Gen Pharmacol 32:653-659.
34. Suh S, Kroh M, Kim N, Joh Y, Cho M. 2002. Effects of red ginseng upon postoperative immunity and survival in patients with stage III gastric cancer. Am J Chin Med 30:483-494.
35. Suh H, Song D, Huh S, Kim Y. 2000. Modulatory role of ginsenosides injected intrathecally or intracerebroventricularly in the production of antinociception induced by kappa-opioid receptor agonist administered intracerebroventricularly in the mouse. Planta Med 66:412-417.
36. Suzuki Y, Hikino H. 1989. Mechanisms of hypoglycaemic activity of panaxans A and B, glycans of Panax ginseng roots: effects on plasma level, secretion, sensitivity and binding of insulin in mice. Phytother Res 3:20-24.
37. Tode T, Kikuchi Y, Hirata J, Kita T, Nakata H, Nagata I. 1999. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynaecol Obstetr 67:169-174.
38. Vuksan V, Sievenpiper JL, Koo VY, Francis T, Beljan-Zdravkovic U, Xu Z, Vidgen E. 2000. American ginseng (Panax quinquefolius l) reduces post prandial glycemia in nondiabetic subjects with type 2 diabetes mellitus. Arch Int Med 160:1009-1013.
39. Winston D, Maimes S. 2007. Adaptogens: Herbs for Strength, Stamina, and Stress Relief. Healing Arts Press.
40. Yoon S, Nah J, Shin Y, Kim SK, Nam KY, Choi HS, Nah SY. 1998. Ginsenosides induce differential antinociception and inhibit substance P induced-nociceptive response in mice. Life Sci 62:319-325.
41. Yuan C-S, Dey L. 2001. Multiple effects of American ginseng in clinical medicine. Am J Chin Med 29:567-569.
42. Zhang JH, Wang JP, Wang HJ. 2007. Clinical study on effect of total Panax notoginseng saponins on immune related inner environment imbalance in rheumatoid arthritis patients, Zhongguo Zhong Xi Yi Jie He Za Zhi 27:589-592.
43. Zhou W, Chai H, Lin P, Lumsden A, Yao Q, Chen C. 2004. Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease. Med Sci Monit 10:187-192.