Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas)

Journal of Clinical Pathology

Volumn 63, Issue 3, 2010, Pages 220-228

  Marchiò, Caterina ^a   Weigelt, Britta ^b   Reis Filho, Jorge S ^c  

^a UNIVERSITY OF TURIN   (Italy)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; IMATINIB; PROTEIN P53; SORAFENIB; STEM CELL FACTOR RECEPTOR; TUMOR MARKER;

ADENOID CYSTIC CARCINOMA; BREAST CARCINOMA; CANCER CHEMOTHERAPY; CANCER CLASSIFICATION; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER SURGERY; CANCER SURVIVAL; CELL TYPE; CHROMOSOME LOSS; CHROMOSOME TRANSLOCATION; CLINICAL TRIAL; DISTANT METASTASIS; DRUG RESEARCH; DRUG TARGETING; DRUG WITHDRAWAL; EXOCRINE GLAND; FUSION GENE; GENE AMPLIFICATION; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPH NODE METASTASIS; MONOTHERAPY; ONCOGENE MYB; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SALIVARY GLAND CARCINOMA; TREATMENT RESPONSE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA, ADENOID CYSTIC; FEMALE; GENOMICS; HUMANS; PROGNOSIS; SALIVARY GLAND NEOPLASMS;

EID: 77749295010     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jcp.2009.073908     Document Type: Review

References (113)

1. Cheuk W, Chan J. Salivary gland tumors. In: Fletcher C, ed. Diagnostic histopathology of tumors. New York: Churchill Livingstone Elsevier, 2007: 280-4.
2. Gray HR, Helwig EB. Epithelioma adenoides cysticum and solitary trichoepithelioma. Arch Dermatol 1963;87:102-14.
3. Hajdu SI, Huvos AG, Goodner JT, et al. Carcinoma of the trachea. Clinicopathologic study of 41 cases. Cancer 1970;25:1448- 56.
4. Huvos AG, Strong EW. Epithelial tumors of the lacrimal gland. Lab Invest 1973;28:386.
5. Lassaletta L, Patron M, Oloriz J, et al. Avoiding misdiagnosis in ceruminous gland tumours. Auris Nasus Larynx 2003;30:287-90.
6. Nelms DC, Luna MA. Primary adenocystic carcinoma (cylindromatous carcinoma) of the esophagus. Cancer 1972;29:440-3.
7. Weltzer S. Adenoid cystic carcinoma of the breast. Am Surg 1970;36:271.
8. Rosen PP. Adenoid cystic carcinoma. In: Rosen PP, ed. Rosen's breast pathology. Philadelphia: Lippincott Williams and Wilkins, 2009:590-604.
9. Persson M, Andren Y, Mark J, et al. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci U S A 2009;106:18740-4.
10. Billroth T. Beobachtungen über Geschwülste der Speicheldrüsen. Virchows Arch Path Anat 1859;17:357-75.
11. Ewing J. Epithelial tumors of the salivary gland, in neoplastic diseases. Philadelphia: WB Saunders, 1919: 780.
12. Geschickter CK. Diseases of the breast, in diagnosis, pathology, treatment. Philadelphia: JB Lippincott, 1945: 824.
13. Ro JY, Silva EG, Gallager HS. Adenoid cystic carcinoma of the breast. Hum Pathol 1987;18:1276-81.
14. Da Silva L, Buck L, Simpson PT, et al. Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis. Virchows Arch 2009;454:107-14.
15. Bennett AK, Mills SE, Wick MR. Salivary-type neoplasms of the breast and lung. Semin Diagn Pathol 2003;20:279-304.
16. Reis-Filho JS, Milanezi F, Silva P, et al. Maspin expression in myoepithelial tumors of the breast. Pathol Res Pract 2001;197:817-21.
17. Ellis GL, Auclair PL. Adenoid cystic carcinoma, in atlas of tumor pathology - tumors of the salivary glands. Washington, DC: Armed Forces Institute of Pathology, 1996: 203-15.
18. Szanto PA, Luna MA, Tortoledo ME, et al. Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer 1984;54:1062-9.
19. Tauxe WN, Mc DJ, Devine KD. A century of cylindromas. short review and report of 27 adenoid cystic carcinomas arising in the upper respiratory passages. Arch Otolaryngol 1962;75:364-76.
20. De Dosso S, Mazzucchelli L, Ghielmini M, et al. Response to oxaliplatin with cetuximab in minor salivary gland adenoid cystic carcinoma. Tumori 2009;95:378-81.
21. Barnes L, Eveson J, Reichart P, et al. Pathology and genetics of head and neck tumours. In: Kleihues R, Sobin LH, eds. World Health Organization classification of tumours. Lyon: IARC, 2005:221-2.
22. Ellis IO, Pinder S, Lee AHS. Tumors of the breast - adenoid cystic carcinoma. In: Fletcher C, ed. Diagnosti histopathology of tumors. Churchill Livingstone Elsevier, 2007: 953-4.
23. Ellis IO, Schnitt SJ, Sastre-Garau X, et al. Invasive Breast Carcinoma. In: Tavassoli FA, Devilee P, eds. World health organization classification of tumours - pathology and genetics, tumours of the breast and female genital organs. Lyon: IARC Press, 2003: 44-5.
24. Friedrich RE, Bleckmann V. Adenoid cystic carcinoma of salivary and lacrimal gland origin: localization, classification, clinical pathological correlation, treatment results and long-term follow-up control in 84 patients. Anticancer Res 2003;23:931-40.
25. Chomette G, Auriol M, Tranbaloc P, et al. Adenoid cystic carcinoma of minor salivary glands. Analysis of 86 cases. Clinico-pathological, histoenzymological and ultrastructural studies. Virchows Arch A Pathol Anat Histol 1982;395:289-301.
26. Conley J, Dingman DL. Adenoid cystic carcinoma in the head and neck (cylindroma). Arch Otolaryngol 1974;100:81-90.
27. Eby LS, Johnson DS, Baker HW. Adenoid cystic carcinoma of the head and neck. Cancer 1972;29:1160-8.
28. Eneroth CM, Zajicek J. Aspiration biopsy of salivary gland tumors. IV. Morphologic studies on smears and histologic sections from 45 cases of adenoid cystic carcinoma. Acta Cytol 1969;13:59-63.
29. Leafstedt SW, Gaeta JF, Sako K, et al. Adenoid cystic carcinoma of major and minor salivary glands. Am J Surg 1971;122:756-62.
30. Matsuba HM, Simpson JR, Mauney M, et al. Adenoid cystic salivary gland carcinoma: a clinicopathologic correlation. Head Neck Surg 1986;8:200-4.
31. Nascimento AG, Amaral AL, Prado LA, et al. Adenoid cystic carcinoma of salivary glands. A study of 61 cases with clinicopathologic correlation. Cancer 1986;57:312-19.
32. Perzin KH, Gullane P, Clairmont AC. Adenoid cystic carcinomas arising in salivary glands: a correlation of histologic features and clinical course. Cancer 1978;42:265-82.
33. Spiro RH, Huvos AG, Strong EW. Adenoid cystic carcinoma of salivary origin a clinicopathologic study of 242 cases. Am J Surg 1974;128:512-20.
34. Wahlberg P, Anderson H, Biorklund A, et al. Carcinoma of the parotid and submandibular glands - a study of survival in 2465 patients. Oral Oncol 2002;38:706-13.
35. Hamper K, Lazar F, Dietel M, et al. Prognostic factors for adenoid cystic carcinoma of the head and neck: a retrospective evaluation of 96 cases. J Oral Pathol Med 1990;19:101-7.
36. Chilla R, Schroth R, Eysholdt U, et al. Adenoid cystic carcinoma of the head and neck. Controllable and uncontrollable factors in treatment and prognosis. ORL J Otorhinolaryngol Relat Spec 1980;42:346-67.
37. Batsakis JG, el-Naggar AK. Myoepithelium in salivary and mammary neoplasms is host-friendly. Adv Anat Pathol 1999;6:218-26.
38. Batsakis JG, Luna MA, el-Naggar A. Histopathologic grading of salivary gland neoplasms: III. Adenoid cystic carcinomas. Ann Otol Rhinol Laryngol 1990;99:1007-9.
39. Chau Y, Hongyo T, Aozasa K, et al. Dedifferentiation of adenoid cystic carcinoma: report of a case implicating p53 gene mutation. Hum Pathol 2001;32:1403-7.
40. Cheuk W, Chan JK, Ngan RK. Dedifferentiation in adenoid cystic carcinoma of salivary gland: an uncommon complication associated with an accelerated clinical course. Am J Surg Pathol 1999;23:465-72.
41. Moles MA, Avila IR, Archilla AR. Dedifferentiation occurring in adenoid cystic carcinoma of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:177-80.
42. Meis JM. "Dedifferentiation" in bone and soft-tissue tumors. A histological indicator of tumor progression. Pathol Annu 1991;26(Pt 1):37-62.
43. Nagao T, Gaffey TA, Serizawa H, et al. Dedifferentiated adenoid cystic carcinoma: a clinicopathologic study of 6 cases. Mod Pathol 2003;16:1265-72.
44. Yu Y, Baras AS, Shirasuna K, et al. Concurrent loss of heterozygosity and copy number analysis in adenoid cystic carcinoma by SNP genotyping arrays. Lab Invest 2007;87:430-9.
45. Yamamoto Y, Wistuba II, Kishimoto Y, et al. DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining. Pathol Int 1998;48:273-80.
46. Kiyoshima T, Shima K, Kobayashi I, et al. Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands. Oral Oncol 2001;37:315-22.
47. Preisegger KH, Beham A, Kopp S, et al. Prognostic impact of molecular analyses in adenoid cystic carcinomas of the salivary gland. Onkologie 2001;24:273-7.
48. Zhu QR, White FH, Tipoe GL. p53 oncoprotein accumulation in adenoid cystic carcinoma of parotid and palatine salivary glands. Pathology 1997;29:154-8.
49. Weigelt B, Horlings HM, Kreike B, et al. Refinement of breast cancer classification by molecular characterization of histological special types. J Pathol 2008;216:141-50.
50. Trendell-Smith NJ, Peston D, Shousha S. Adenoid cystic carcinoma of the breast: a tumour commonly devoid of oestrogen receptors and related proteins. Histopathology 1999;35:241-8.
51. Vila L, Liu H, Al-Quran SZ, et al. Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. Mod Pathol 2009;22:1296-302.
52. Vranic S, Bilalovic N, Lee LM, et al. PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney. Hum Pathol 2007;38:1425-31.
53. Enamorado I, Lakhani R, Korkmaz H, et al. Correlation of histopathological variants, cellular DNA content, and clinical outcome in adenoid cystic carcinoma of the salivary glands. Otolaryngol Head Neck Surg 2004;131:646-50.
54. Arpino G, Clark GM, Mohsin S, et al. Adenoid cystic carcinoma of the breast: molecular markers, treatment, and clinical outcome. Cancer 2002;94:2119-27.
55. Nordkvist A, Mark J, Gustafsson H, et al. Non-random chromosome rearrangements in adenoid cystic carcinoma of the salivary glands. Genes Chromosomes Cancer 1994;10:115-21.
56. Jin Y, Mertens F, Limon J, et al. Characteristic karyotypic features in lacrimal and salivary gland carcinomas. Br J Cancer 1994;70:42-7.
57. Martins C, Fonseca I, Roque L, et al. Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Cancer Genet Cytogenet 2001;128:130-6.
58. Bell D, Zhao Y, Rao HP, et al. Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongue. Head Neck Pathol 2007;1:165-8.
59. Stenman G, Sandros J, Dahlenfors R, et al. 6q- and loss of the Y chromosome - two common deviations in malignant human salivary gland tumors. Cancer Genet Cytogenet 1986;22:283-93.
60. el-Naggar AK, Lovell M, Callender DL, et al. Limited nonrandom chromosomal aberrations in a recurrent adenoid cystic carcinoma of the parotid gland. Cancer Genet Cytogenet 1999;109:66-9.
61. Bernheim A, Toujani S, Saulnier P, et al. High-resolution array comparative genomic hybridization analysis of human bronchial and salivary adenoid cystic carcinoma. Lab Invest 2008;88:464-73.
62. Sequeiros-Santiago G, Garcia-Carracedo D, Fresno MF, et al. Oncogene amplification pattern in adenoid cystic carcinoma of the salivary glands. Oncol Rep 2009;21:1215-22.
63. Greer RO Jr, Said S, Shroyer KR, et al. Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. Oral Oncol 2007;43:735- 41.
64. Rao PH, Roberts D, Zhao YJ, et al. Deletion of 1p32-p36 is the most frequent genetic change and poor prognostic marker in adenoid cystic carcinoma of the salivary glands. Clin Cancer Res 2008;14:5181-7.
65. Mark HF, Hanna I, Gnepp DR. Cytogenetic analysis of salivary gland type tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:187-92.
66. Patel KJ, Pambuccian SE, Ondrey FG, et al. Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma. Oral Oncol 2006;42:994-1004.
67. Frierson HF Jr, El-Naggar AK, Welsh JB, et al. Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol 2002;161:1315-23.
68. Edwards PC, Bhuiya T, Kelsch RD. C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:586-93.
69. Holst VA, Marshall CE, Moskaluk CA, et al. KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. Mod Pathol 1999;12:956-60.
70. Jeng YM, Lin CY, Hsu HC. Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma. Cancer Lett 2000;154:107-11.
71. Volker HU, Scheich M, Berndt A, et al. Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses. Diagn Pathol 2009;4:18.
72. Mastropasqua MG, Maiorano E, Pruneri G, et al. Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast. Mod Pathol 2005;18:1277-82.
73. Azoulay S, Lae M, Freneaux P, et al. KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. Mod Pathol 2005;18:1623-31.
74. Crisi GM, Marconi SA, Makari-Judson G, et al. Expression of c-kit in adenoid cystic carcinoma of the breast. Am J Clin Pathol 2005;124:733-9.
75. Rutherford S, Yu Y, Rumpel CA, et al. Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma. Cancer Lett 2006;236:309-17.
76. Rutherford S, Hampton GM, Frierson HF, et al. Mapping of candidate tumor suppressor genes on chromosome 12 in adenoid cystic carcinoma. Lab Invest 2005;85:1076-85.
77. Galloway JR, Woolner LB, Clagett OT. Adenoid cystic carcinoma of the breast. Surg Gynecol Obstet 1966;122:1289-94.
78. Azzopardi JE. Problems in breast pathology. London: WB Saunders, 1979.
79. Wells CA, Nicoll S, Ferguson DJ. Adenoid cystic carcinoma of the breast: a case with axillary lymph node metastasis. Histopathology 1986;10:415-24.
80. Acs G, Simpson JF, Bleiweiss IJ, et al. Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. Am J Surg Pathol 2003;27:1052-60.
81. James BA, Cranor ML, Rosen PP. Carcinoma of the breast arising in microglandular adenosis. Am J Clin Pathol 1993;100:507-13.
82. Khalifeh IM, Albarracin C, Diaz LK, et al. Clinical, histopathologic, and immunohistochemical features of microglandular adenosis and transition into in situ and invasive carcinoma. Am J Surg Pathol 2008;32:544-52.
83. Koenig C, Dadmanesh F, Bratthauer GL, et al. carcinoma arising in microglandular adenosis: an immunohistochemical analysis of 20 intraepithelial and invasive neoplasms. Int J Surg Pathol 2000;8:303-15.
84. Tavassoli FA, Norris HJ. Mammary adenoid cystic carcinoma with sebaceous differentiation. A morphologic study of the cell types. Arch Pathol Lab Med 1986;110:1045-53.
85. Kleer CG, Oberman HA. Adenoid cystic carcinoma of the breast: value of histologic grading and proliferative activity. Am J Surg Pathol 1998;22:569-75.
86. Lamovec J, Us-Krasovec M, Zidar A, et al. Adenoid cystic carcinoma of the breast: a histologic, cytologic, and immunohistochemical study. Semin Diagn Pathol 1989;6:153-64.
87. McGuire WL, De La Garza M, Chamness GC. Evaluation of estrogen receptor assays in human breast cancer tissue. Cancer Res 1977;37:637-9.
88. Hayat MA. Microscopy, immunohistochemistry and antigen retrieval methods for light and electron microscopy. New York: Kluwer Academic/Plenum Publisher, 2002.
89. Weigelt B, Baehner FL, Reis-Filho JS. The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade. J Pathol 2010;220:263-80.
90. Weigelt B, Reis-Filho JS. Histological and molecular types of breast cancer: is there a unifying taxonomy. Nat Rev Clin Oncol 2009;6:718-30.
91. Hu Z, Fan C, Oh DS, et al. The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 2006;7:96.
92. Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.
93. Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 2003;100:8418-23.
94. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
95. Peppercorn J, Perou CM, Carey LA. Molecular subtypes in breast cancer evaluation and management: divide and conquer. Cancer Invest 2008;26:1-10.
96. Reis-Filho JS, Milanezi F, Steele D, et al. Metaplastic breast carcinomas are basal-like tumours. Histopathology 2006;49:10-21.
97. Lae M, Freneaux P, Sastre-Garau X, et al. Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum. Mod Pathol 2009;22:291-8.
98. Rakha EA, Reis-Filho JS, Ellis IO. Basal-like breast cancer: a critical review. J Clin Oncol 2008;26:2568-81.
99. Weigelt B, Kreike B, Reis-Filho JS. Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis. Breast Cancer Res Treat 2009; 117:273-80.
100. Reis-Filho JS, Tutt AN. Triple negative tumours: a critical review. Histopathology 2008;52:108-18.
101. Manie E, Vincent-Salomon A, Lehmann-Che J, et al. High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors. Cancer Res 2009;69:663-71.
102. Pastolero G, Hanna W, Zbieranowski I, et al. Proliferative activity and p53 expression in adenoid cystic carcinoma of the breast. Mod Pathol 1996;9:215-19.
103. Pandis N, Teixeira MR, Gerdes AM, et al. Chromosome abnormalities in bilateral breast carcinomas. cytogenetic evaluation of the clonal origin of multiple primary tumors. Cancer 1995;76:250-8.
104. Faivre S, Raymond E, Casiraghi O, et al. Imatinib mesylate can induce objective response in progressing, highly expressing KIT adenoid cystic carcinoma of the salivary glands. J Clin Oncol 2005;23:6271-3; author reply 6273-4.
105. Lin CH, Yen RF, Jeng YM, et al. Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate. Head Neck 2005;27:1022-7.
106. Pfeffer MR, Talmi Y, Catane R, et al. A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands. Oral Oncol 2007;43:33-6.
107. Hotte SJ, Winquist EW, Lamont E, et al. Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: a Princess Margaret Hospital Phase II Consortium Study. J Clin Oncol 2005;23:585-90.
108. Slevin NJ, Mais KL, Bruce I, et al. Imatinib with cisplatin in recurrent and/or metastatic salivary adenoidcystic carcinoma - response assessed by FDG-PET scanning [abstract]. J Clin Oncol 2004;22:5604.
109. Hornick JL, Fletcher CD. The role of KIT in the management of patients with gastrointestinal stromal tumors. Hum Pathol 2007;38:679-87.
110. Foschini MP, Reis-Filho JS, Eusebi V, et al. Salivary gland-like tumours of the breast: surgical and molecular pathology. J Clin Pathol 2003;56:497-506.
111. Di Palma S, Skalova A, Ungari M, et al. Pure salivary duct carcinomas can be classified into luminal, Her2 and basal-like phenotypes. Abstract 1072. Mod Pathol 2008;21(Suppl 1).
112. Aparicio SA, Huntsman DG. Does massively parallel DNA resequencing signify the end of histopathology as we know it? J Pathol 2010;220:307-15.
113. Reis-Filho JS. Next generation sequencing. Breast Cancer Res 2009;11(Suppl 3): S12. Revie