Motor neurone disease - A methyl bromide exposure cluster points to a causal mechanism

Human and Experimental Toxicology

Volumn 29, Issue 3, 2010, Pages 241-242

  Shaw, Ian ^a  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DNA; FREE RADICAL; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; METHYL BROMIDE; XANTHINE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CELL PROTECTION; DISEASE COURSE; ENZYME ACTIVITY; EXPOSURE; FAMILY HISTORY; GENE EXPRESSION; GENETIC PREDISPOSITION; HUMAN; HYDROXYLATION; MOTOR NEURON DISEASE; NERVE CELL DEGENERATION; NEUROPATHOLOGY; OXIDATIVE STRESS; PRIORITY JOURNAL; RISK FACTOR; SPINAL CORD;

AMYOTROPHIC LATERAL SCLEROSIS; CLUSTER ANALYSIS; FREE RADICALS; FUMIGATION; HUMANS; HYDROCARBONS, BROMINATED; INCIDENCE; NEW ZEALAND; OCCUPATIONAL EXPOSURE; RISK ASSESSMENT; RISK FACTORS;

EID: 77749282894     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327109359462     Document Type: Article

References (9)

1. Haverkamp LJ, Appel V., Appel SH Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction. Brain 1995 ; 118: 707-719.
2. Rosen DR, Siddique T., Patterson D., et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993 ; 362: 59-62.
3. Fitzmaurice PS, Shaw IC, Mitchell JD Alteration of superoxide dismutase activity in the anterior horn in motoneuron disease patients. J Neurol Sci 1995 ; 129: 96-98.
4. Shaw IC, Fitzmaurice PS, Mitchell JD, Lynch PG Studies on cellular free radical protection mechanisms in the anterior horn from patients with amyotropic lateral sclerosis. Neurodegeneration 1995 ; 4: 391-396.
5. Fitzmaurice PS, Shaw IC, Kleiner HE, et al. Evidence for DNA damage in amyotrophic lateral sclerosis. Muscle Nerve 1996 ; 19: 797-798.
6. Shaw IC Could exposure to methyl bromide cause motor neurone disease? NZ Med J 2005 ; 118: 1208.
7. Kiddle E. Cluster investigation into motor neurone disease, Public Health Service, Nelson Marlborough District Health Board, Nelson, New Zealand - available at http://www.mnda.org.nz/resources.html
8. Shaw PJ Clinical review. Motor Neurone Disease. BMJ 1999 ; 318: 1118-1121.
9. Gansewendt B., Xu D., Foest U., Hallier E., Bolt HM, Peter H. DNA binding of methyl iodide in male and female F344 rats. Carcinogenesis 1991 ; 12, 463-467.