Insulin therapy stimulates lipid synthesis and improves endocrine functions of adipocytes in dietary obese C57BL/6 mice

Acta Pharmacologica Sinica

Volumn 31, Issue 3, 2010, Pages 341-346

  Chen, Xiang ^a   Yu, Qiu Qiong ^a   Zhu, Yan Hua ^a   Bi, Yan ^a   Sun, Wei Ping ^a   Liang, Hua ^a   Cai, Meng Ying ^a   He, Xiao Ying ^a   Weng, Jian Ping ^a  

^a THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Adipocyte; Adiponectin; Endocrine functions; Fatty acid synthase; Insulin action; Insulin resistance; Interleukin 6; Lipid metabolism; Phosphoenolpyruvate carboxykinase; Visfatin

Indexed keywords

ADIPONECTIN; AQUAPORIN 7; FATTY ACID SYNTHASE; INSULIN GLARGINE; INTERLEUKIN 6; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL FUNCTION; CONTROLLED STUDY; DRUG TARGETING; ENDOCRINE FUNCTION; GLUCOSE TOLERANCE TEST; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TREATMENT; LIPID DIET; LIPOGENESIS; LIVER; METABOLISM; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SKELETAL MUSCLE; TISSUE LEVEL; WESTERN BLOTTING;

ADIPOCYTES; ADIPONECTIN; ANIMALS; AQUAPORINS; CARBOXY-LYASES; FATTY ACID SYNTHETASE COMPLEX; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-6; LIPID METABOLISM; MICE; MICE, INBRED C57BL; MICE, OBESE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OBESITY;

EID: 77749277261     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.17     Document Type: Article

References (20)

1. Weng J, Li Y, Xu W, Shi L, Zhang Q, Zhu D, et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 2008; 371: 1753-60.
2. Li Y, Xu W, Liao Z, Yao B, Chen X, Huang Z, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care 2004; 27: 2597-602.
3. Ryan EA, Imes S, Wallace C. Short-term intensive insulin therapy in newly diagnosed type 2 diabetes. Diabetes Care 2004; 27: 1028-32.
4. Matthaei S, Stumvoll M, Kellerer M, Haring HU. Pathophysiology and pharmacological treatment of insulin resistance. Endocr Rev 2000; 21: 585-618.
5. Tordjman J, Chauvet G, Quette J, Beale EG, Forest C, Antoine B. Thiazolidinediones block fatty acid release by inducing glycero-neogenesis in fat cells. J Biol Chem 2003; 278: 18785-90.
6. Bogacka I, Xie H, Bray GA, Smith SR. The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivo. Diabetes Care 2004; 27: 1660-7.
7. Kishida K, Kuriyama H, Funahashi T, Shimomura I, Kihara S, Ouchi N, et al. Aquaporin adipose, a putative glycerol channel in adipocytes. J Biol Chem 2000; 275: 20896-902.
8. Hibuse T, Maeda N, Funahashi T, Yamamoto K, Nagasawa A, Mizunoya W, et al. Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proc Natl Acad Sci USA 2005; 102: 10993-8.
9. Waki H, Tontonoz P. Endocrine functions of adipose tissue. Annu Rev Pathol 2007; 2: 31-56.
10. Westerbacka J, Corner A, Kannisto K, Kolak M, Makkonen J, Korsheninnikova E, et al. Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects. Diabetologia 2006; 49: 132-40.
11. Anderwald C, Bernroider E, Krssak M, Stingl H, Brehm A, Bisch of MG, et al. Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscle. Diabetes 2002; 51: 3025-32.
12. O'Brien RM, Granner DK. Regulation of gene expression by insulin. Physiol Rev 1996; 76: 1109-61.
13. Hall RK, Yamasaki T, Kucera T, Waltner-Law M, O'Brien R, Granner DK. Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins. J Biol Chem 2000; 275: 30169-75.
14. Nishino N, Tamori Y, Kasuga M. Insulin efficiently stores triglycerides in adipocytes by inhibiting lipolysis and repressing PGC-1alpha induction. Kobe J Med Sci 2007; 53: 99-106.
15. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7: 941-6.
16. Kern PA, Di Gregorio GB, Lu T, Rassouli N, Ranganathan G. Adipo-nectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes 2003; 52: 1779-85.
17. Yamamoto Y, Hirose H, Saito I, Tomita M, Taniyama M, Matsubara K, et al. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond) 2002; 103: 137-42.
18. Motoshima H, Wu X, Sinha MK, Hardy VE, Rosato EL, Barbot DJ, et al. Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone. J Clin Endocrinol Metab 2002; 87: 5662-7.
19. Lopez-Bermejo A, Chico-Julia B, Fernandez-Balsells M, Recasens M, Esteve E, Casamitjana R, et al. Serum visfatin increases with progressive beta-cell deterioration. Diabetes 2006; 55: 2871-5.
20. Chen MP, Chung FM, Chang DM, Tsai JC, Huang HF, Shin SJ, et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2006; 91: 295-9.