Phosphodiesterase type 4 inhibition does not restore ocular dominance plasticity in a ferret model of fetal alcohol spectrum disorders

Alcoholism: Clinical and Experimental Research

Volumn 34, Issue 3, 2010, Pages 493-498

  Krahe, Thomas E ^a   Paul, Arco P ^a   Medina, Alexandre E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

FAS; FASD; Neuronal Plasticity; Rolipram; Vinpocetine; Visual Cortex

Indexed keywords

ALCOHOL; PHOSPHODIESTERASE IV; ROLIPRAM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG DOSE COMPARISON; ELECTROPHYSIOLOGY; ENZYME INHIBITION; EYE DOMINANCE; EYELID CLOSURE; FERRET; FETAL ALCOHOL SYNDROME; IN VIVO STUDY; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NONHUMAN; OCULAR DOMINANCE IMPAIRMENT; PRIORITY JOURNAL; SUTURING METHOD; THIRD TRIMESTER PREGNANCY; VISUAL CORTEX;

ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DOMINANCE, OCULAR; FEMALE; FERRETS; FETAL ALCOHOL SYNDROME; NEURONAL PLASTICITY; PHOSPHODIESTERASE INHIBITORS; PREGNANCY; ROLIPRAM;

ANIMALIA; MAMMALIA; MUSTELA;

EID: 77749260962     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2009.01114.x     Document Type: Article

References (48)

1. Bailey CD, Brien JF, Reynolds JN (2004) Chronic prenatal ethanol exposure alters the proportion of GABAergic neurons in layers II/III of the adult guinea pig somatosensory cortex. Neurotoxicol Teratol 26 : 59 63.
2. Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E (1998) Rolipram, a type IV-specific phophodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci U S A 95 : 15020 15025.
3. Beavo JA (1995) Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 75 : 725 748.
4. Bender AT, Beavo JA (2006) Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev 58 : 488 520.
5. Berardi N, Pizzorusso T, Ratto GM, Maffei L (2003) Molecular basis of plasticity in the visual cortex. Trends Neurosci 26 : 369 378.
6. Bertolino A, Crippa D, di Dio S, Fichte K, Musmeci G, Porro V, Rapisarda V, Sastre-y-Hernandez M, Schratzer M (1988) Rolipram versus imipramine in inpatients with major, "minor" or atypical depressive disorder: a double-blind double-dummy study aimed at testing a novel therapeutic approach. Int Clin Psychopharmacol 3 : 245 253.
7. Bito H, Deisseroth K, Tsien RW (1996) CREB phosphorylation and dephosphorylation: a Ca++ and stimulus duration dependent switch for hippocampal gene expression. Cell 87 : 1203 1214.
8. Blokland A, Schreiber R, Prickaerts J (2006) Improving memory: a role for phosphodiesterases. Curr Pharm Des 12 : 2511 2523.
9. Bourtchouladze R, Lidge R, Catapano R, Stanley J, Gossweiler S, Romashko D, Scott R, Tully T (2003) A mouse model of Rubinstein-Taybi syndrome: defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4. Proc Natl Acad Sci U S A 100 : 10518 10522.
10. Chen CP, Kuhn P, Chaturvedi K, Boyadjieva N, Sarkar DK (2006) Ethanol induces apoptotic death of developing -endorphin neurons via suppression of cyclic adenosine monophosphate production and activation of transforming growth factor-1-linked apoptotic signaling. Mol Pharmacol 69 : 717.
11. Chen L, Muzzio IA, Malleret G, Bartsch D, Verbitsky M, Pavlidis P, Yonan AL, Vronskaya S, Grody MB, Cepeda I, Gilliam TC, Kandel ER (2003) Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins. Neuron 39 : 655 669.
12. Clancy B, Darlington RB, Finlay BL (2001) Translating developmental time across mammalian species. Neuroscience 105 : 7 17.
13. Clements KM, Girard TA, Ellard CG, Wainwright PE (2005) Short-term memory impairment and reduced hippocampal c-Fos expression in an animal model of fetal alcohol syndrome. Alcohol Clin Exp Res 29 : 1049 1059.
14. Crowe SF, Neath J, Hale MW (2009) The type 4 phosphodiesterase inhibitors rolipram and YM976 facilitate recall of the weak version of the passive avoidance task in the day-old chick. Pharmacol Biochem Behav 92 : 224 230.
15. Deisseroth K, Bito H, Tsien RW (1996) Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron 16 : 89 101.
16. Dyke HJ, Montana JG (1999) The therapeutic potential of PDE4 inhibitors. Expert Opin Investig Drugs 8 : 1301 1325.
17. Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME (1997) CREB: a major mediator of neuronal neurotrophin responses. Neuron 19 : 1031 1047.
18. Frank DA, Greenberg ME (1994) CREB: a mediator of long-term memory from mollusks to mammals. Cell 79 : 5 8.
19. Ghavami A, Hirst WD, Novak TJ (2006) Selective phosphodiesterase (PDE)-4 inhibitors: A novel approach to treating memory deficit? Drugs R D 7 : 63 71.
20. Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O (2004) Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest 114 : 1624 1634.
21. Goodlett CR, Peterson SD (1995) Sex differences in vulnerability to developmental spatial learning deficits induced by limited binge alcohol exposure in neonatal rats. Neurobiol Learn Mem 64 : 265 275.
22. Hubel DH, Wiesel TN (1970) The period of susceptibility to the physiological effects of unilateral eye closure in kittens. J Physiol 206 : 419 436.
23. Hubel DH, Wiesel TN, LeVay S (1977) Plasticity of ocular dominance columns in monkey striate cortex. Philos Trans R Soc Lond B Biol Sci 278 : 377 409.
24. Issa NP, Trachtenberg JT, Chapman B, Zahs KR, Stryker MP (1999) The critical period for ocular dominance plasticity in the ferret's visual cortex. J Neurosci 19 : 6965 6978.
25. Josselyn SA, Nguyen PV (2005) CREB, synapses and memory disorders: past progress and future challenges. Curr Drug Targets CNS Neurol Disord 4 : 481 497.
26. Karacay B, Li G, Pantazis NJ, Bonthius DJ (2007) Stimulation of the cAMP pathway protects cultured cerebellar granule neurons against alcohol-induced cell death by activating the neuronal nitric oxide synthase (nNOS) gene. Brain Res 1143 : 34 45.
27. Krahe TE, Medina AE, Bittencourt-Navarrete RE, Colello RJ, Ramoa AS (2005) Protein synthesis independent plasticity mediates rapid and precise recovery of deprived eye responses. Neuron 48 : 329 343.
28. Krahe TE, Wang W, Medina AE (2008) Vinpocetine increase phosphorylation of CREB and restores orientation selectivity in a ferret model of fetal alcohol spectrum disorder. Int J Dev Neurosci 26 : 890.
29. Lamprecht R (2005) CREB: a message to remember. Cell Mol Life Sci 55 : 554 563.
30. Lynch G (2002) Memory enhancement: the search for mechanism-based drugs. Nat Neurosci 5 : 1035 1038.
31. Maas JW Jr., Indacochea RA, Muglia LM, Tran TT, Vogt SK, West T, Benz A, Shute AA, Holtzman DM, Mennerick S, Olney JW, Muglia LJ (2005) Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain. J Neurosci 25 : 2376 2385.
32. Medina AE, Krahe TE (2008) Neocortical plasticity deficits in fetal alcohol spectrum disorders: lessons from barrel and visual cortex. J Neurosci Res 86 : 256 263.
33. Medina AE, Krahe TE, Coppola DM, Ramoa AS (2003) Neonatal alcohol exposure induces long-lasting impairment of visual cortical plasticity in ferrets. J Neurosci 23 : 10002 10012.
34. Medina AE, Krahe TE, Ramoa AS (2005) Early alcohol exposure induces persistent alteration of cortical columnar organization and reduced orientation selectivity in the visual cortex. J Neurophysiol 93 : 1317 1325.
35. Medina AE, Krahe TE, Ramoa AS (2006) Restoration of neuronal plasticity by a phosphodiesterase type 1 inhibitor in a model of fetal alcohol exposure. J Neurosci 26 : 1057 1060.
36. Medina AE, Ramoa AS (2005) Early alcohol exposure impairs ocular dominance plasticity throughout the critical period. Brain Res Dev Brain Res 157 : 107 111.
37. Mower AF, Liao DS, Nestler EJ, Neve RL, Ramoa AS (2002) cAMP/Ca2+ response element-binding protein function is essential for ocular dominance plasticity. J Neurosci 22 : 2237 2245.
38. Otmakhov N, Khibnick L, Otmakhova N, Carpenter S, Riahi S, Asrican B, Lisman J (2004) Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent. J Neurophysiol 91 : 1955 1962.
39. Powrozec TA, Zhou FC (2005) effects of prenatal alcohol exposure on the development of the vibrissal somatosensory cortical barrel network. Brain Res Dev Brain Res 155 : 135 146.
40. Rema V, Ebner FF (1999) Effect of enriched environment rearing on impairments in cortical excitability and plasticity after prenatal alcohol exposure. J Neurosci 19 : 10993 11006.
41. Richardson DP, Byrnes ML, Brien JF, Reynolds JN, Dringenberg HC (2002) Impaired acquisition in the water maze and hippocampal long-term potentiation after chronic prenatal ethanol exposure in the guinea-pig. Eur J Neurosci 16 : 1593 1598.
42. Roberson R, Cameroni I, Toso L, Abebe D, Bissel S, Spong CY (2009) Alterations in phosphorylated cyclic adenosine monophosphate response element of binding protein activity: a pathway for fetal alcohol syndrome-related neurotoxicity. Am J Obstet Gynecol 200 : 193.e1 193.e5.
43. Robichaud A, Savoie C, Stamatiou PB, Tattersall FD, Chan CC (2001) PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway. Neuropharmacology 40 : 262 269.
44. Rose GM, Hopper A, De Vivo M, Tehim A (2005) Phosphodiesterase inhibitors for cognitive enhancement. Curr Pharm Des 11 : 3329 3334.
45. Rutten K, Lieben C, Smits L, Blokland A (2007) The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat. Psychopharmacology (Berl) 192 : 275 282.
46. Tully T, Bourtchouladze R, Scott R, Tallman J (2003) Targeting the CREB pathway for memory enhancers. Nat Rev Drug Discov 2 : 267 277.
47. Van Staveren WC, Markerink-van Ittersum M, Steinbusch HW, de Vente J (2001) The effects of phosphodiesterase inhibition on cyclic GMP and cyclic AMP accumulation in the hippocampus of the rat. Brain Res 888 : 275 286.
48. Zhang H, O'Donnell JM (2000) Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats. Psychopharmacology (Berl) 150 : 316.