A prospective open-label trial of lamotrigine monotherapy in children and adolescents with bipolar disorder

CNS Neuroscience and Therapeutics

Volumn 16, Issue 2, 2010, Pages 91-102

  Biederman, Joseph ^a,b   Joshi, Gagan ^a,b   Mick, Eric ^a,b   Doyle, Robert ^a,b   Georgiopoulos, Anna ^a,b   Hammerness, Paul ^a,b   Kotarski, Meghan ^a   Williams, Courtney ^a   Wozniak, Janet ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Bipolar disorder; Children; Lamotrigine

Indexed keywords

DIPHENHYDRAMINE; LAMOTRIGINE;

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; BIPOLAR DEPRESSION; BIPOLAR DISORDER; BIPOLAR DISORDER NOT OTHERWISE SPECIFIED; BIPOLAR I DISORDER; BIPOLAR II DISORDER; BODY WEIGHT; BRIEF PSYCHIATRIC RATING SCALE; BURN; CHAPPED LIPS; CHILD; CHILD PSYCHIATRY; CHILDREN DEPRESSION RATING SCALE; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CLINICAL TRIAL; COMMON COLD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG ERUPTION; DRUG FATALITY; DRUG HYPERSENSITIVITY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ERYTHEMA; ERYTHEMA MULTIFORME; FEMALE; GASTROINTESTINAL SYMPTOM; GROUPS BY AGE; HUMAN; INCREASED APPETITE; INFECTION; IRRITABILITY; LABORATORY TEST; LUNG DISEASE; MACULOPAPULAR RASH; MALE; MANIA; MONOTHERAPY; MUCOSAL DRYNESS; MUSCULOSKELETAL DISEASE; OPEN STUDY; PATIENT COMPLIANCE; PATIENT MONITORING; PETECHIAE; PILOT STUDY; PRESCHOOL CHILD; PSYCHOLOGICAL RATING SCALE; PSYCHOSIS; QT INTERVAL; RESTLESSNESS; SCHOOL CHILD; SEDATION; SELF REPORT; SIDE EFFECT; SKIN DISCOLORATION; SKIN IRRITATION; SKIN PRURITUS; SODIUM BLOOD LEVEL; STEVENS JOHNSON SYNDROME; THROMBOCYTE COUNT; VESCICULAR RASH; VESICULAR RASH; VITAL SIGN; YOUNG MANIA RATING SCALE;

ADOLESCENT; ANTICONVULSANTS; BIPOLAR DISORDER; CHILD; DRUG ADMINISTRATION SCHEDULE; EVALUATION STUDIES AS TOPIC; FEMALE; HUMANS; MALE; PEDIATRICS; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; TREATMENT OUTCOME; TRIAZINES;

EID: 77749258988     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2009.00121.x     Document Type: Article

References (51)

1. Wozniak J. Pediatric bipolar disorder: The new perspective on severe mood dysfunction in children. J Child Adolesc Psychopharmacol 2003 13 : 449 451.
2. Geller B, Fox L, Clark K. Rate and predictors of prepubertal bipolarity during follow-up 6- to 12-year-old depressed children. J Am Acad Child Adolesc Psychiatry 1994 33 : 461 468.
3. Lewinsohn P, Klein D, Seeley J. Bipolar disorders in a community sample of older adolescents: Prevalence, phenomenology, comorbidity, and course. J Am Acad Child Adolesc Psychiatry 1995 34 : 454 463.
4. Biederman J, Mick E, Faraone SV, Spencer T, Wilens TE, Wozniak J. Pediatric mania: A developmental subtype of bipolar disorder? Biol Psychiatry 2000 48 : 458 466. (Pubitemid 30702472)
5. Biederman J, Mick E, Bostic J, et al. The naturalistic course of pharmacologic treatment of children with manic-like symptoms: A systematic chart review. J Clin Psychiatry 1998 59 : 628 637 quiz 38.
6. Tohen M, Ketter TA, Zarate CA, et al. Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: A 47-week study. Am J Psychiatry 2003 160 : 1263 1271.
7. Keck PE Jr., Versiani M, Potkin S, West SA, Giller E, Ice K. Ziprasidone in the treatment of acute bipolar mania: A three-week, placebo-controlled, double-blind, randomized trial. Am J Psychiatry 2003 160 : 741 748.
8. Perlis RH, Welge JA, Vornik LA, Hirschfeld RM, Keck PE Jr. Atypical antipsychotics in the treatment of mania: A meta-analysis of randomized, placebo-controlled trials. J Clin Psychiatry 2006 67 : 509 516.
9. Frazier JA, Biederman J, Tohen M, et al. A prospective open-label treatment trial of olanzapine monotherapy in children and adolescents with bipolar disorder. J Child Adolesc Psychopharmacol 2001 11 : 239 250.
10. Biederman J, Mick E, Wozniak J, Aleardi M, Spencer T, Faraone SV. An open-label trial of risperidone in children and adolescents with bipolar disorder. J Child Adolesc Psychopharmacol 2005 15 : 311 317. (Pubitemid 40734110)
11. Biederman J, Mick E, Hammerness P, et al. Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-aged children. Biol Psychiatry 2005 58 : 589 594.
12. DelBello MP, Kowatch RA, Adler CM, et al. A double-blind randomized pilot study comparing quetiapine and divalproex for adolescent mania. J Am Acad Child Adolesc Psychiatry 2006 45 : 305 313.
13. Bowden C, Calabrese J, McElroy S, et al. The efficacy of Lamotrigine in rapid cycling and non-rapid cycling patients with bipolar disorder. Biol Psychiatry 1999 45 : 953 958. (Pubitemid 29219615)
14. Bowden CL, Asnis GM, Ginsberg LD, Bentley B, Leadbetter R, White R. Safety and tolerability of lamotrigine for bipolar disorder. Drug Safety 2004 27 : 173 184.
15. Fatemi SH, Rapport DJ, Calabrese JR, Thuras P. Lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry 1997 58 : 522 527.
16. Passmore MJ, Garnham J, Duffy A, et al. Phenotypic spectra of bipolar disorder in responders to lithium versus lamotrigine. Bipolar Disord 2003 5 : 110 114.
17. Obrocea GV, Dunn RM, Frye MA, et al. Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders. Biol Psychiatry 2002 51 : 253 260.
18. Marangell LB, Martinez JM, Ketter TA, et al. Lamotrigine treatment of bipolar disorder: Data from the first 500 patients in STEP-BD. Bipolar Disord 2004 6 : 139 143.
19. Calabrese JR, Suppes T, Bowden CL, et al. A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group. J Clin Psychiatry 2000 61 : 841 850.
20. Sporn J, Sachs G. The anticonvulsant lamotrigine in treatment-resistant manic-depressive illness. J Clin Psychopharmacol 1997 17 : 185 189.
21. Yatham LN, Kusumakar V, Parikh SV, et al. Bipolar depression: Treatment options. Can J Psychiatry 1997 42 (Suppl 2 87S 91S.
22. Ichim L, Berk M, Brook S. Lamotrigine compared with lithium in mania: A double-blind randomized controlled trial. Ann Clin Psychiatry 2000 12 : 5 10.
23. Calabrese JR, Sullivan JR, Bowden CL, et al. Rash in multicenter trials of lamotrigine in mood disorders: Clinical relevance and management. J Clin Psychiatry 2002 63 : 1012 1019.
24. Orvaschel H, Puig-Antich J. Schedule for Affective Disorders and Schizophrenia for School-Age Children: Epidemiologic Version. Fort Lauderdale, FL : Nova University, 1987.
25. Fristad MA, Weller RA, Weller EB. The Mania Rating Scale (MRS): Further reliability and validity studies with children. Ann Clin Psychiatry 1995 7 : 127 132.
26. Fristad MA, Weller EB, Weller RA. The Mania Rating Scale: Can it be used in children? A preliminary report. J Am Acad Child Adolesc Psychiatry 1992 31 : 252 257.
27. Young R, Biggs J, Ziegler V, Meyer D. A rating scale for mania: Reliability, validity and sensitvity. Br J Psychiatry 1978 133 : 429 435. (Pubitemid 9006756)
28. Youngstrom EA, Danielson CK, Findling RL, Gracious BL, Calabrese JR. Factor structure of the Young Mania Rating Scale for use with youths ages 5 to 17 years. J Clin Child Adolesc Psychol 2002 31 : 567 572.
29. Poznanski EO, Cook SC, Carroll BJ. A depression rating scale for children. Pediatrics 1979 64 : 442 450.
30. Lachar D, Bailley SE, Rhoades HM, et al. New subscales for an anchored version of the brief psychiatric rating scale: Construction, reliability, and validity in acute psychiatric admissions. Psychol Assess 2001 13 : 384 395.
31. National Institute of Mental Health. CGI (Clinical Global Impression) Scale-NIMH. Psychopharmacol Bull 1985 21 : 839 844.
32. Chang K, Saxena K, Howe M. An open-label study of lamotrigine adjunct or monotherapy for the treatment of adolescents with bipolar depression. J Am Acad Child Adolesc Psychiatry 2006 45 : 298 304.
33. Kowatch RA, Suppes T, Carmody TJ, et al. Effect size of lithium, divalproex sodium, and carbamazepine in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 2000 39 : 713 720.
34. Pavuluri MN, Henry DB, Carbray JA, Naylor MW, Janicak PG. Divalproex sodium for pediatric mixed mania: A 6-month prospective trial. Bipolar Disord 2005 7 : 266 273.
35. Wagner KD, Weller E, Carlson GA, et al. An open-label trial of divalproex in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 2002 41 : 1224 1230. (Pubitemid 38338042)
36. Redden L, DelBello M, Wagner KD, et al. Long-term safety of divalproex sodium extended-release in children and adolescents with bipolar I disorder. J Child Adolesc Psychopharmacol 2009 19 : 83 89.
37. Wagner KD, Redden L, Kowatch RA, et al. A double-blind, randomized, placebo-controlled trial of divalproex extended-release in the treatment of bipolar disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry 2009 48 : 519 532.
38. Weisler RH, Hirschfeld R, Cutler AJ, et al. Extended-release carbamazepine capsules as monotherapy in bipolar disorder: Pooled results from two randomised, double-blind, placebo-controlled trials. CNS Drugs 2006 20 : 219 231.
39. ®) monotherapy in children with bipolar disorder. J Child Adolesc Psychopharmacol 2009 in press.
40. Wagner KD, Kowatch RA, Emslie GJ, et al. A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents. Am J Psychiatry 2006 163 : 1179 1186.
41. Calabrese J, Bowden C, Sachs G, Ascher J, Monaghan E, Rudd D. A double-blind placebo-controlled study of lamotrigine, monotherapy in outpatients with bipolar I depression. J Clin Psychiatry 1999 60 : 79 88.
42. Goodwin GM, Bowden CL, Calabrese JR, et al. A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. J Clin Psychiatry 2004 65 : 432 441.
43. Chang KD, Wagner C, Garrett A, Howe M, Reiss A. A preliminary functional magnetic resonance imaging study of prefrontal-amygdalar activation changes in adolescents with bipolar depression treated with lamotrigine. Bipolar Disord 2008 10 : 426 431.
44. Soutullo CA, Diez-Suarez A, Figueroa-Quintana A. Adjunctive lamotrigine treatment for adolescents with bipolar disorder: Retrospective report of five cases. J Child Adolesc Psychopharmacol 2006 16 : 357 364.
45. Tohen M, Zarate CA Jr., Centorrino F, Hegarty JI, Froeschl M, Zarate SB. Risperidone in the treatment of mania. J Clin Psychiatry 1996 57 : 249 253.
46. Wozniak J, Biederman J, Kiely K, et al. Mania-like symptoms suggestive of childhood onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry 1995 34 : 867 876.
47. Wozniak J, Biederman J, Faraone S, et al. Mania in children with pervasive developmental disorder revisited. J Am Acad Child Adolesc Psychiatry 1997 36 : 1552 1560.
48. Biederman J, Faraone SV, Mick E, et al. Attention deficit hyperactivity disorder and juvenile mania: An overlooked comorbidity? J Am Acad Child Adolesc Psychiatry 1996 35 : 997 1008. (Pubitemid 26266330)
49. Koehler-Troy C, Strober M, Malenbaum R. Methylphenidate-induced mania in a prepubertal child. J Clin Psychiatry 1986 47 : 566 567.
50. Schmidt K, Delaney MA, Jensen M, Levinson DF, Lewitt M. Methylphenidate challenge in a manic boy. Biol Psychiatry 1986 21 : 1107 1109.
51. Soutullo CA, DelBello MP, Ochsner JE, McElroy SL, Taylor SA, Strakowski SM, Keck PE Jr. Severity of bipolarity in hospitalized manic adolescents with history of stimulant or antidepressant treatment. J Affect Disord 2002 70 : 323 327.