Intravenous hemostat: Nanotechnology to halt bleeding

Science Translational Medicine

Volumn 1, Issue 11, 2009, Pages

  Bertram, James P ^a   Williams, Cicely A ^b   Robinson, Rebecca ^a   Segal, Steven S ^c,d   Flynn, Nolan T ^e   Lavik, Erin B ^f  

^a Yale University   (United States)

^b YALE UNIVERSITY   (United States)

^c University of Missouri   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

^e WELLESLEY COLLEGE   (United States)

^f Case Western Reserve University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; HEMOSTATIC AGENT; NANOPARTICLE; OLIGOPEPTIDE;

ADOLESCENT; ADULT; ANIMAL; ARTICLE; BLEEDING; BLOOD CLOTTING; CHEMISTRY; CHILD; DRUG EFFECT; EVALUATION; HEMOSTASIS; HUMAN; INJURY; INSTRUMENTATION; MALE; METABOLISM; METHODOLOGY; NANOTECHNOLOGY; PRESCHOOL CHILD; RAT; SPRAGUE DAWLEY RAT; THROMBOCYTE; WAR;

ADOLESCENT; ADULT; ANIMALS; BLOOD COAGULATION; BLOOD PLATELETS; CHILD; CHILD, PRESCHOOL; HEMORRHAGE; HEMOSTATIC TECHNIQUES; HEMOSTATICS; HUMANS; MALE; NANOPARTICLES; NANOTECHNOLOGY; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; WAR; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 77749238159     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3000397     Document Type: Article

References (38)

1. E. G. Krug, G. K. Sharma, R. Lozano, The global burden of injuries. Am. J. Public Health 90, 523-526 (2000).
2. H. R. Champion, R. F. Bellamy, C. P. Roberts, A. Leppaniemi, A profile of combat injury. J. Trauma 54, S13-S19 (2003).
3. A. Sauaia, F. A. Moore, E. E. Moore, K. S. Moser, R. Brennan, R. A. Read, P. T. Pons, Epidemiology of trauma deaths: A reassessment. J. Trauma 38, 185-193 (1995).
4. G. Regel, M. Stalp, U. Lehmann, A. Seekamp, Prehospital care, importance of early intervention on outcome. Acta Anaesthesiol. Scand. Suppl. 110, 71-76 (1997).
5. H. W. Kim, A. G. Greenburg, Toward 21st century blood component replacement therapeutics: Artificial oxygen carriers, platelet substitutes, recombinant clotting factors, and others. Artif. Cells Blood Substit. Immobil. Biotechnol. 34, 537-550 (2006).
6. M. A. Blajchman, Substitutes for success. Nat. Med. 5, 17-18 (1999).
7. K. D. Boffard, B. Riou, B. Warren, P. I. T. Choong, S. Rizoli, R. Rossaint, M. Axelsen, Y. Kluger, 63rd Annual Meeting of the American Association for the Surgery of Trauma, Maui, HI, 2004, pp. 8-16.
8. P. Benharash, F. Bongard, B. Putnam, Annual Meeting of the Southern California Chapter of the American College of Surgeons, Southeastern Surgical Congress, Santa Barbara, CA, 2005, pp. 776-780.
9. D. H. Lee, M. A. Blajchman, Novel treatment modalities: New platelet preparations and substitutes. Br. J. Haematol. 114, 496-505 (2001).
10. R. G. Ellis-Behnke, Y. X. Liang, D. K. Tay, P. W. Kau, G. E. Schneider, S. Zhang, W. Wu, K. F. So, Nano hemostat solution: Immediate hemostasis at the nanoscale. Nanomedicine 2, 207-215 (2006).
11. A. S. Gupta, G. Huang, B. J. Lestini, S. Sagnella, K. Kottke-Marchant, R. E. Marchant, RGDmodified liposomes targeted to activated platelets as a potential vascular drug delivery system. Thromb. Haemost. 93, 106-114 (2005).
12. Y. Okamura, Y. Fukui, K. Kabata, H. Suzuki, M. Handa, Y. Ikeda, S. Takeoka, Novel platelet substitutes: Disk-shaped biodegradable nanosheets and their enhanced effects on platelet aggregation. Bioconjug. Chem. 20, 1958-1965 (2009).
13. N. S. Wong, T. M. Chang, Polyhemoglobin-fibrinogen: A novel oxygen carrier with platelet-like properties in a hemodiluted setting. Artif. Cells Blood Substit. Immobil. Biotechnol. 35, 481-489 (2007).
14. M. L. Hans, A. M. Lowman, Biodegradable nanoparticles for drug delivery and targeting. Curr. Opin. Solid State Mater. Sci. 6, 319-327 (2002).
15. R. Gref, M. Luck, P. Quellec, M. Marchand, E. Dellacherie, S. Harnisch, T. Blunk, R. H. Muller, 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): Influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf. B Biointerfaces 18, 301-313 (2000).
16. J. H. Beer, K. T. Springer, B. S. Coller, Immobilized Arg-Gly-Asp (RGD) peptides of varying lengths as structural probes of the platelet glycoprotein IIb/IIIa receptor. Blood 79, 117-128 (1992).
17. Y. Hirano, M. Okuno, T. Hayashi, K. Goto, A. Nakajima, Cell-attachment activities of surface immobilized oligopeptides RGD, RGDS, RGDV, RGDT, and YIGSR toward five cell lines. J. Biomater. Sci. Polym. Ed. 4, 235-243 (1993).
18. J. Fuglsang, M. Stender, J. Zhou, J. Møller, E. Falk, H. B. Ravn, Platelet activity and in vivo arterial thrombus formation in rats with mild hyperhomocysteinaemia. Blood Coagul. Fibrinolysis 13, 683-689 (2002).
19. U. Martinowitz, G. Kenet, E. Segal, J. Luboshitz, A. Lubetsky, J. Ingerslev, M. Lynn, Recombinant activated factor VII for adjunctive hemorrhage control in trauma. J. Trauma 51, 431-438; discussion 438-439 (2001).
20. B. Bell, D. Canty, M. Audet, Hemophilia: An updated review. Pediatr. Rev. 16, 290 - 298 (1995).
21. J. G. Eley, V. D. Pujari, J. McLane, Poly (lactide-co-glycolide) nanoparticles containing coumarin-6 for suppository delivery: In vitro release profile and in vivo tissue distribution. Drug Deliv. 11, 255-261 (2004).
22. E. Chambers, S. Mitragotri, Long circulating nanoparticles via adhesion on red blood cells: Mechanism and extended circulation. Exp. Biol. Med. (Maywood) 232, 958-966 (2007).
23. U. Hersel, C. Dahmen, H. Kessler, RGD modified polymers: Biomaterials for stimulated cell adhesion and beyond. Biomaterials 24, 4385-4415 (2003).
24. M. Ebara, M. Yamato, T. Aoyagi, A. Kikuchi, K. Sakai, T. Okano, The effect of extensible PEG tethers on shielding between grafted thermo-responsive polymer chains and integrin- RGD binding. Biomaterials 29, 3650- 3655 (2008).
25. R. Pytela, M. D. Pierschbacher, M. H. Ginsberg, E. F. Plow, E. Ruoslahti, Platelet membrane glycoprotein IIb/IIIa: Member of a family of Arg-Gly-Asp -specific adhesion receptors. Science 231, 1559-1562 (1986).
26. M. D. Pierschbacher, E. Ruoslahti, Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion. J. Biol. Chem. 262, 17294-17298 (1987).
27. M. D. Pierschbacher, E. Ruoslahti, Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309, 30-33 (1984).
28. T. Boxus, R. Touillaux, G. Dive, J. Marchand-Brynaert, Synthesis and evaluation of RGD peptidomimetics aimed at surface bioderivatization of polymer substrates. Bioorg. Med. Chem. 6, 1577-1595 (1998).
29. N. L. Benoiton, Chemistry of Peptide Synthesis (CRC Press, Boca Raton, FL, 2006). Downloaded from stm.sciencemag.org on June 13, 2014
30. A. Radomski, P. Jurasz, D. Alonso-Escolano, M. Drews, M. Morandi, T. Malinski, M. W. Radomski, Nanoparticle-induced platelet aggregation and vascular thrombosis. Br. J. Pharmacol. 146, 882-893 (2005).
31. H. Sahli, J. Tapon-Bretaudière, A. M. Fischer, C. Sternberg, G. Spenlehauer, T. Verrecchia, D. Labarre, Interactions of poly(lactic acid) and poly(lactic acid-co-ethylene oxide) nanoparticles with the plasma factors of the coagulation system. Biomaterials 18, 281-288 (1997).
32. T. M. Chang, D. Powanda, W. P. Yu, Analysis of polyethylene-glycol- polylactide nanodimension artificial red blood cells in maintaining systemic hemoglobin levels and prevention of methemoglobin formation. Artif. Cells Blood Substit. Immobil. Biotechnol. 31, 231-247 (2003).
33. R. A. Jain, The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 21, 2475-2490 (2000).
34. J. M. Harris, Laboratory synthesis of polyethylene glycol derivatives. J. Macromol. Sci. C Polym. Rev. 25, 325-373 (1985).
35. N. S. Kleiman, A. M. Lincoff, G. C. Flaker, K. S. Pieper, R. G. Wilcox, L. G. Berdan, T. J. Lorenz, D. V. Cokkinos, M. L. Simoons, E. Boersma, E. J. Topol, R. M. Califf, R. A. Harrington; PURSUIT Investigators, Early percutaneous coronary intervention, platelet inhibition with eptifibatide, and clinical outcomes in patients with acute coronary syndromes. Circulation 101, 751-757 (2000).
36. A. L. Klibanov, K. Maruyama, V. P. Torchilin, L. Huang, Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 268, 235-237 (1990).
37. C. Deng, X. Chen, H. Yu, J. Sun, T. Lu, X. Jing, A biodegradable triblock copolymer poly(ethylene glycol)- b-poly(L-lactide)- b-poly(L-lysine): Synthesis, self-assembly, and RGD peptide modification. Polymer 48, 139-149 (2007).
38. B. S. Coller, K. T. Springer, J. H. Beer, N. Mohandas, L. E. Scudder, K. J. Norton, S. M. West, Thromboerythrocytes. In vitro studies of a potential autologous, semiartificial alternative to platelet transfusions. J. Clin. Invest. 89, 546-555 (1992).