Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation

Journal of Ethnopharmacology

Volumn 128, Issue 2, 2010, Pages 533-536

  Mishra, Nibha ^a   Oraon, Awadesh ^a   Dev, Abhimanyu ^a   Jayaprakash, Venkatesan ^a   Basu, Arijit ^a   Pattnaik, Ashok K ^a   Tripapthi, Satya N ^a   Akhtar, Mustari ^a   Ahmad, Sadab ^a   Swaroop, Shreyshri ^a   Basu, Mahua ^b  

^a BIRLA INSTITUTE OF TECHNOLOGY   (India)

^b Shri Shikshayatan College   (India)

Author keywords

Anticonvulsant; Benkara malabarica; GABA transaminase

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID; BENKARA MALABARICA EXTRACT; DIAZEPAM; ISONIAZID; PHENYTOIN; PLANT EXTRACT; SCOPOLETIN; STRYCHNINE; UNCLASSIFIED DRUG; VIGABATRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BENKARA MALABARICA; CONTROLLED STUDY; CONVULSION; DRUG MECHANISM; ENZYME ASSAY; ENZYME INHIBITION; ENZYME ISOLATION; IN VITRO STUDY; IN VIVO STUDY; LD 50; MALE; NONHUMAN; PLANT; PLANT ROOT; RAT;

4-AMINOBUTYRATE TRANSAMINASE; ANIMALS; ANTICONVULSANTS; DIAZEPAM; DRUG INTERACTIONS; ENZYME ASSAYS; GAMMA-AMINOBUTYRIC ACID; LETHAL DOSE 50; MALE; MICE; PHENYTOIN; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, WISTAR; RUBIACEAE; SCOPOLETIN; SEIZURES;

BENKARA MALABARICA; RATTUS; STRYCHNOS TOXIFERA;

EID: 77649342571     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.01.042     Document Type: Article

References (21)

1. Adesina S.K. Constituents of Solanum dasyphyllum fruit. Journal of Natural Products 48 (1985) 147-1147
2. Anjaneyulu B., Rao V.B., and Ganguli A.K. Chemical investigation of some Indian plants. Indian Journal of Chemistry 3 (1965) 237-238
3. Bhakuni D.S., Char M.L., Dhar M.M., and Dhawan B.N. Screening of Indian plants for biological activity. Journal of Experimental Biology 9 (1971) 91-102
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Annals of Biochemistry 72 (1976) 248-254
5. Bum E.N., Schmutz M., Meyer C., Rakotonirina A.M., Bopelet M., Portet C., Jeker A., Rakotonirina S.V., Olpe H.R., and Herrling P. Anticonvulsant properties of the methanolic extract of Cyperus articulatus (Cyperaceae). Journal of Ethnopharmacology 76 (2001) 145-150
6. Carpinella M.C., Ferrayoli C.G., and Palacios S.M. Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits. Journal of Agricultural and Food Chemistry 53 (2005) 2922-2927
7. Gram L., Larsson M., Johnen A., and Schousboe A. Experimental studies of the influence of vigabatrin on the GABA system. Bristish Journal of Clinical Pharmacology 27 (1989) 13S-17S
8. Jayasinghe U.L.B., Jayasooriya C.P., Bandara B.M.R., Ekanayake S.P., Merlini L., and Assante G. Antimicrobial activity of some Sri Lankan Rubiaceae and Meliaceae. Fitoterapia 73 (2002) 424-427
9. Kevin L., and Wallace M.D. Antibiotic-induced convulsions. Critical Care Clinics 13 (1997) 741-762
10. Larson A.A., and Beitz A.J. Glycine potentiates strychnine-induced convulsions: role of NMDA receptors. Journal of Neuroscience 8 (1988) 3822-3828
11. Lorke D. A new approach to acute toxicity testing. Archives of Toxicology 54 (1983) 275-287
12. Nadkarnu K.M. Indian Materia Medica (2000), Popular Prakashan, Mumbai pp. 347-348
13. Rajendra S., Lynch J.W., and Schofield P.R. The glycine receptor. Pharmacology and Therapeutics 73 (1997) 121-146
14. Raza M., Shaheen F., Choudhary M.I., Suria A., Atta-ur-, Rahman, Sombati S., and DeLorenzo R.J. Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum. Phytotherapy Research 15 (2000) 426-430
15. Ricci L., Frosini M., Gaggelli N., Valensin G., Machetti F., Sgaragli G., and Valoti M. Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis. Biochemical Pharmacology 71 (2006) 1510-1519
16. Salvador R.A., and Albers R.W. The distribution of glutamic gamma-aminobutyric transaminase in the nervous system of the rhesus monkey. Journal of Biological Chemistry 234 (1959) 922-925
17. Schousboe A., and Waagepetersen H.S. GABA: homeostatic and pharmacological aspects. Progress in Brain Research 160 (2007) 9-19
18. Shapizadeh F., and Melnikoff A.B. Coumarins of Artemisia tridentata ssp. vaseyana. Phytochemistry 9 (1970) 1311-1316
19. Trease G.E., and Evans M.C. Textbook of Pharmacognosy (2002), Balliere Tindall, London
20. White H.S. Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs. Epilepsia 40 (1999) SZ-S10
21. Wood J.D., and Peesker S.J. The role of GABA metabolism in the convulsant and anticonvulsant actions of aminooxyacetic acid. Journal of Neurochemistry 20 (1973) 379-387