Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum

Phytotherapy Research

Volumn 15, Issue 5, 2001, Pages 426-430

  Raza, Mohsin ^a   Shaheen, Farzana ^b   Choudhary, M I ^a,b   Suria, Amin ^c   Rahman, Atta Ur ^b   Sombati, Sompong ^a   Delorenzo, R J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KARACHI   (Pakistan)

^c AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

Author keywords

Anticonvulsant activity; Delphinium denudatum; FS 1 subfraction; Roots; Traditional medicine

Indexed keywords

ANTICONVULSIVE AGENT; BICUCULLINE; PENTETRAZOLE; PHENYTOIN; PICROTOXIN; PLANT EXTRACT; STRYCHNINE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CONVULSION; DELPHINIUM DENUDATUM; DOSE RESPONSE; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; ELECTRIC SHOCK; EPILEPSY; HINDLIMB; MALE; MORTALITY; MOUSE; NONHUMAN; PLANT ROOT; RIGHTING REFLEX; TONIC SEIZURE;

ANGIOSPERMS; ANIMALS; ANTICONVULSANTS; BICUCULLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; EPILEPSY, GENERALIZED; MALE; MICE; MUSCLE CONTRACTION; PENTYLENETETRAZOLE; PICROTOXIN; PLANT EXTRACTS; PLANT ROOTS; PLANTS, MEDICINAL;

ANIMALIA; DELPHINIUM; DELPHINIUM DENUDATUM; RANUNCULACEAE; STRYCHNOS TOXIFERA;

EID: 0034889643     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.792     Document Type: Article

References (35)

1. The electroshock model, neuronal network and antiepileptic drugs
2. Do anticonvulsants alter the natural course of epilepsy? Case for early treatment is not established
3. Characterization of ethosuximide: Reduction of low-threshold calcium current in thalamic neurons
4. Natural products in drug discovery and development
5. Cognitive and behavioral effects of antiepileptic drugs
6. Ethnopharmacology and drug development
7. Analysis of jadwar, a controversial herbal drug
8. Strategies for the development of drugs for pharmacoresistant epilepsies
9. Antiepileptic drug development: II. Anticonvulsant drug screening
10. An analysis of the action of strychnine on the recurrent IPSP and amino acid-induced inhibitions in the cat spinal cord
11. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models
12. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models
13. Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: A common mode of convulsant action
14. Mechanisms of action of currently prescribed and newly developed antiepileptic drugs
15. Efficacy and adverse effects of established and new antiepileptic drugs
16. Update on the mechanism of action of antiepileptic drugs
17. Identification and preclinical testing of novel antiepileptic compounds
18. Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor
19. Antiepileptic drug development program
20. Anticonvulsant medicinal plants
21. Anticonvulsant effects in vivo and inhibition of neuronal excitability in vitro by an aqueous fraction isolated from Delphinium denudatum
22. The pharmacologic basis of antiepileptic drug action
23. Maternal use of antiepileptic drugs and the risk of major congenital malformations: A joint European prospective study of human teratogenesis associated with maternal epilepsy
24. Epidemiology of epilepsies
25. Does antiepileptic drug therapy alter the prognosis of childhood seizures and prevent the development of chronic epilepsy?
26. Does antiepileptic drug therapy prevent the development of chronic epilepsy?
27. The epidemiology and treatment of chronic and refractory epilepsy
28. Convulsive disorders: Toxicity of anticonvulsants
29. Electrically induced convulsions
30. Antiepileptic drugs: Detection, quantification and evaluation
31. A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish
32. Gabapentin: Mechanism of action
33. Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures
34. The National Institute of Health anticonvulsant drug development program: Screening for efficacy