Initial brain lesion size affects the extent of subsequent pathophysiological responses

Brain Research

Volumn 1322, Issue , 2010, Pages 109-117

  Nagai, Nobuo ^a   Kawao, Naoyuki ^a   Okada, Kiyotaka ^a   Ishida, Chikako ^a   Okumoto, Katsumi ^a   Ueshima, Shigeru ^a,b   Suzuki, Yasuhiro ^c   Umemura, Kazuo ^c   Matsuo, Osamu ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Ischemic stroke; Pathophysiological response

Indexed keywords

UROKINASE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN DAMAGE; BRAIN SIZE; CEREBROVASCULAR ACCIDENT; EXPERIMENTAL MODEL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; ASTROCYTES; BRAIN; BRAIN INFARCTION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; GLIOSIS; INTRACRANIAL THROMBOSIS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; PHOTIC STIMULATION; PHOTOCHEMISTRY; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR;

MUS;

EID: 77649341196     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.01.077     Document Type: Article

References (24)

1. Anderson M.F., Blomstrand F., Blomstrand C., Eriksson P.S., and Nilsson M. Astrocytes and stroke: networking for survival?. Neurochem. Res. 28 (2003) 293-305
2. Arboix A., and Marti-Vilalta J.L. Lacunar stroke. Expert Rev. Neurother. 9 (2009) 179-196
3. Bader M., Bohnemeier H., Zollmann F.S., Lockley-Jones O.E., and Ganten D. Transgenic animals in cardiovascular disease research. Exp. Physiol. 85 (2000) 713-731
4. Barone F.C., Knudsen D.J., Nelson A.H., Feuerstein G.Z., and Willette R.N. Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy. J Cereb Blood Flow Metab 13 (1993) 683-692
5. Bederson J.B., Pitts L.H., Germano S.M., Nishimura M.C., Davis R.L., and Bartkowski H.M. Evaluation of 2, 3, 5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17 (1986) 1304-1308
6. Coyle P. Spatial relations of dorsal anastomoses and lesion border after middle cerebral artery occlusion. Stroke 18 (1987) 1133-1140
7. Cubellis M.V., Andreasen P., Ragno P., Mayer M., Dano K., and Blasi F. Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor. Proc Natl Acad Sci U.S.A. 86 (1989) 4828-4832
8. Dewerchin M., Nuffelen A.V., Wallays G., Bouche A., Moons L., Carmeliet P., Mulligan R.C., and Collen D. Generation and characterization of urokinase receptor-deficient mice. J. Clin. Invest 97 (1996) 870-878
9. Institute of Laboratory Animal Research, C.o.L.S., and National Research Council. Guide for the Care and Use of Laboratory Animals (1996), National Academy Press, Washington, D.C
10. Ito U., Ohno K., Nakamura R., Suganuma F., and Inaba Y. Brain edema during ischemia and after restoration of blood flow. Measurement of water, sodium, potassium content and plasma protein permeability. Stroke 10 (1979) 542-547
11. Kim G.W., Sugawara T., and Chan P.H. Involvement of oxidative stress and caspase-3 in cortical infarction after photothrombotic ischemia in mice. J. Cereb. Blood Flow Metab. 20 (2000) 1690-1701
12. Klatzo I., Wisniewski H., and Smith D.E. Observations on penetration of serum proteins into the central nervous system. Prog. Brain Res. 15 (1965) 73-88
13. Nagai N., De Mol M., Lijnen H.R., Carmeliet P., and Collen D. Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. Circulation 99 (1999) 2440-2444
14. Nagai N., De Mol M., Van Hoef B., Verstreken M., and Collen D. Depletion of circulating alpha(2)-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization. Blood 97 (2001) 3086-3092
15. Nagai N., Demarsin E., Van Hoef B., Wouters S., Cingolani D., Laroche Y., and Collen D. Recombinant human microplasmin: production and potential therapeutic properties. J Thromb Haemost 1 (2003) 307-313
16. Nagai N., Okada K., Kawao N., Ishida C., Ueshima S., Collen D., and Matsuo O. Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke. Neurosci. Lett. 432 (2008) 46-49
17. Nagai N., Suzuki Y., Van Hoef B., Lijnen H.R., and Collen D. Effects of plasminogen activator inhibitor-1 on ischemic brain injury in permanent and thrombotic middle cerebral artery occlusion models in mice. J Thromb Haemost 3 (2005) 1379-1384
18. Pekny M., and Nilsson M. Astrocyte activation and reactive gliosis. Glia 50 (2005) 427-434
19. Schroeter M., Jander S., Huitinga I., Witte O.W., and Stoll G. Phagocytic response in photochemically induced infarction of rat cerebral cortex. The role of resident microglia. Stroke 28 (1997) 382-386
20. Stoll G., Jander S., and Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog. Neurobiol. 56 (1998) 149-171
21. Takamatsu H., Tatsumi M., Nitta S., Ichise R., Muramatsu K., Iida M., Nishimura S., and Umemura K. Time courses of progress to the chronic stage of middle cerebral artery occlusion models in rats. Exp. Brain Res. 146 (2002) 95-102
22. Tuttolomondo A., Di Raimondo D., di Sciacca R., Pinto A., and Licata G. Inflammatory cytokines in acute ischemic stroke. Curr Pharm Des 14 (2008) 3574-3589
23. Watson B.D., Dietrich W.D., Busto R., Wachtel M.S., and Ginsberg M.D. Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann. Neurol. 17 (1985) 497-504
24. Wood P.L. Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia. Neurol. Res. 17 (1995) 242-248