Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation

FEBS Journal

Volumn 274, Issue 14, 2007, Pages 3611-3621

  Serrano, Solange M T ^b   Wang, Deyu ^a   Shannon, John D ^a   Pinto, Antonio F M ^c   Polanowska Grabowska, Renata K ^d   Fox, Jay W ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b INSTITUTO BUTANTAN   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Cysteine rich domain; Platelet aggregation; Snake venom metalloproteinase; Von Willebrand factor; VWA

Indexed keywords

ATROLYSIN A; ATROLYSIN C; CATROCOLLASTATIN C; COLLAGEN; CYSTEINE; DISINTEGRIN; MATRILIN 3; METALLOPROTEINASE; RISTOCETIN; SCLEROPROTEIN; SNAKE VENOM; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ARTICLE; BINDING SITE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SURFACE PLASMON RESONANCE; THROMBOCYTE AGGREGATION; THROMBOCYTE RICH PLASMA;

AMINO ACID MOTIFS; BLOOD PLATELETS; CYSTEINE; CYTOPROTECTION; ENZYMES, IMMOBILIZED; HUMANS; KINETICS; METALLOPROTEASES; PLATELET AGGREGATION; PLATELET-RICH PLASMA; PROTEIN BINDING; RISTOCETIN; SNAKE VENOMS; SUBSTRATE SPECIFICITY; VON WILLEBRAND FACTOR;

EID: 34447309053     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.05895.x     Document Type: Article

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