Effects of vitamin A supplementation on intestinal barrier function, growth, total parasitic, and specific giardia spp infections in Brazilian children: A prospective randomized, double-blind, placebo-controlled trial

Journal of Pediatric Gastroenterology and Nutrition

Volumn 50, Issue 3, 2010, Pages 309-315

  Lima, Aldo A M ^a   Soares, Alberto M ^a   Lima, Noélia L ^a   Mota, Rosa M S ^a   MacIel, Bruna L L ^a   Kvalsund, Michelle P ^c   Barrett, Leah J ^c   Fitzgerald, Relana P ^c   Blaner, William S ^b   Guerrant, Richard L ^c  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b New York Presbyterian Columbia University Medical Center   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Diarrheal diseases; Giardia spp; Growth; Inflammation; Intestinal barrier function; Retinol

Indexed keywords

BIOLOGICAL MARKER; LACTOFERRIN; RETINOL PALMITATE; TOCOPHEROL;

AGE; ARTICLE; ASTHMA; BODY HEIGHT; BODY WEIGHT; BRAZIL; BRONCHITIS; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIGESTIVE TRACT PARAMETERS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENTERITIS; FECES ANALYSIS; FEMALE; FEVER; FOLLOW UP; FURUNCULOSIS; GIARDIASIS; HORDEOLUM; HUMAN; IMPETIGO; INFANT; INTESTINAL BARRIER FUNCTION; INTESTINE FUNCTION; INTESTINE MUCOSA PERMEABILITY; INTESTINE PARASITE; MAJOR CLINICAL STUDY; MALE; MICROBIAL GROWTH; NUTRITIONAL PARAMETERS; NUTRITIONAL STATUS; PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SCHOOL CHILD; TONSILLITIS; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ADJUVANTS, IMMUNOLOGIC; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FECES; FEMALE; GIARDIASIS; GROWTH; HUMANS; INFLAMMATION; INTESTINAL MUCOSA; LACTOFERRIN; MALE; PROTOZOAN INFECTIONS; VITAMIN A; VITAMINS;

GIARDIA;

EID: 77649329851     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e3181a96489     Document Type: Article

References (33)

1. Fawzi WW, Chalmers TC, Herrera MG, et al. Vitamin A supplementation and child mortality. A meta-analysis. JAMA 1993;269:898-903.
2. Glasziou PP, Mackerras DE. Vitamin A supplementation in infectious diseases: a meta-analysis. BMJ 1993;306:366-370
3. Grotto I, Mimouni M, Gdalevich M, et al. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J Pediatr 2003;142:297-304.
4. Long KZ, Rosado JL, DuPont HL, et al. Supplementation with vitamin A reduces watery diarrhoea and respiratory infections in Mexican children. Br J Nutr 2007;97:337-343
5. Cantorna MT, Nashold FE, Hayes CE. Vitamin A deficiency results in a priming environment conducive for Th1 cell development. Eur J Immunol 1995;25:1673-1679
6. Cantorna MT, Nashold FE, Chun TY, et al. Vitamin A down-regulation of IFN-g synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway. J Immunol 1996;156:2674-2679
7. Quadro L, Gamble MV, Vogel S, et al. Retinol and retinol-binding protein: gut integrity and circulating immunoglobulins. J Infect Dis 2000;182 (Suppl 1):97-102.
8. Thurnham DI, Northrop-Clewes CA, McCullough FS, et al. Innate immunity, gut integrity, and vitamin A in Gambian and Indian infants. J Infect Dis 2000;182 (Suppl 1):23-28
9. Chen P, Soares AM, Lima AA, et al. Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil. J Health Popul Nutr 2003;21:309-315
10. Long KZ, Santos JI, Rosado JL, et al. Impact of vitamin A on selected gastrointestinal pathogen infections and associated diarrheal episodes among children in Mexico City, Mexico. J InfectDis 2006;194:1217-1225
11. Long KZ, Santos JI, Estrada Garcia T, et al. Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children. J Nutr 2006;136:2600-2605
12. Hadi H, Stoltzfus RJ, Dibley MJ, et al. Vitamin A supplementation selectively improves the linear growth of Indonesian preschool children: resultsfromarandomizedcontrolledtrial.AmJClinNutr2000;71:507-513
13. Villamor E, Mbise R, Spiegelman D, et al. Vitamin A supplements ameliorate the adverse effect of HIV-1, malaria, and diarrheal infections on child growth. Pediatrics 2002;109:E6.
14. Roncada MJ,Wilson D, Netto OB, et al. Hipovitaminose A em filhos de migrantes nacionais em transito pela capital do Estado de Sao Paulo, Brasil: estudo cĺnico-bioqúmico. Rev Saúde Publica 1978;12:345-350
15. Lima AA, Moore SR, Barboza MS Jr et al. Persistent diarrhea signals a critical period of increased diarrhea burdens and nutritional shortfalls: a prospective cohort study among children in northeastern Brazil. J Infect Dis 2000;181:1643-1651
16. Good Clinical Practice Handbook. Bethesda, MD: Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Services; 2001.
17. Code of Federal Regulations & ICH Guidelines, April 1, 2001, Title 21 - Food & Drugs, Good Clinical Practice and ICH as Adopted by the Food and Drug Administration. Silver Spring, MD: Food and Drug Administration.
18. Mills JL, Tuomilehto J, Yu KF, et al. Maternal vitamin levels during pregnancies producing infants with neural tube defects. J Pediatr 1992;120:863-871
19. Redlich CA, Grauer JN, Van Bennekum AM, et al. Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages. Am J Respir Crit Care Med 1996;154: 1436-1443
20. Barboza Junior MS, Silva TM, Guerrant RL, et al. Measurement of intestinal permeability using mannitol and lactulose in children with diarrheal diseases. Braz J Med Biol Res 1999;32:1499-1504
21. Lunn PG, Northrop CA, Northrop AJ. Automated enzymatic assays for the determination of intestinal permeability probes in urine. 2. Mannitol. Clin Chim Acta 1989;183:163-170
22. Northrop CA, Lunn PG, Behrens RH. Automated enzymatic assays for the determination of intestinal permeability in urine. 1. Lactulose and lactose. Clin Chim Acta 1990;187:163-170
23. Vieira MM, Jisunk P, Blanner WS, et al. Carotenoids, retinol and intestinal barrier function in children from Northeast of Brazil. J Pediatr Gastroentrol Nutr 2008;47:652-659
24. McCullough FS, Northrop-Clewes CA, Thurnham DI. The effect of vitamin A on epithelial integrity. Proc Nutr Soc 1999;58:289-293
25. Filteau SM, Rollins NC, Coutsoudis A, et al. The effect of antenatal vitamin A and b-carotene supplementation on gut integrity of infants of HIV-infected South African women. J Pediatr Gastroentrol Nutr 2001;32:464-470
26. Rollins NC, Filteau SM, Elson I, et al. Vitamin A supplementation of South African children with severe diarrhea: optimum timing for improving biochemical and clinical recovery and subsequent vitamin A status. Pediatr Infect Dis J 2000;19:284-289
27. Coombes JL, Siddiqui KR, Arancibia-Cárcamo CV, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007;204:1757-1764
28. Sun CM, Hall JA, Blank RB, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007;204:1775-1785
29. Benson MJ, Pino-Lagos K, Rosemblatt M, et al. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 2007;204:1765-1774
30. Abdul-Wahid A, Faubert G. Characterization of the local response to cyst antigens during the acute and elimination phases of primary murine giardiasis. Int J Parasitol 2008;38:691-693
31. Arroyave G, Aguilar JR, Flores M, et al. Evaluation of sugar fortification with vitamin A at the national level. Washington, DC: Pan American Health Organization; 1979.
32. Lie C, Ying C, Wang EL, et al. Impact of large-dose vitamin A supplementation on childhood diarrhoea, respiratory disease and growth. Eur J Clin Nutr 1993;47:88-96.
33. Ramakrishnan U, Latham MC, Abel R. Vitamin A supplementation does not improve growth of preschool children: a randomized, doubleblind field trial in south India. J Nutr 1995;125:202-211