Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress

Virology Journal

Volumn 7, Issue 1, 2010, Pages

  Tang, Qing Hai ^a   Zhang, Yan Ming ^a   Fan, Li ^a   Tong, Gang ^a   He, Lei ^a   Dai, Chen ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; I KAPPA B; NONSTRUCTURAL PROTEIN 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; VIRULENCE FACTOR; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIVISION; CELL GROWTH; CELLULAR DISTRIBUTION; CLASSICAL SWINE FEVER; CLASSICAL SWINE FEVER VIRUS; CONCURRENT INFECTION; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL CELL LINE; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; VIRUS REPLICATION; ANIMAL; CELL LINE; CHEMISTRY; ENDOTHELIUM CELL; HOST PATHOGEN INTERACTION; METABOLISM; PATHOGENICITY; PATHOLOGY; PESTIVIRUS; SWINE; VIROLOGY;

ANIMALS; CELL LINE; CLASSICAL SWINE FEVER VIRUS; CYCLIN A; ENDOPLASMIC RETICULUM; ENDOTHELIAL CELLS; HOST-PATHOGEN INTERACTIONS; NF-KAPPA B; S PHASE; SWINE; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE FACTORS;

EID: 77649300652     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-7-4     Document Type: Article

References (31)

1. Dreier S, Zimmermann B, Moennig V, Greiser-Wilke I: A sequence database allowing automated genotyping of Classical swine fever virus isolates. J Virol Methods 2007, 140:95-99.
2. Harada T, Tautz N, Thiel HJ: E2-p7 region of the bovine viral diarrhea virus polyprotein: processing and functional studies. J Virol 2000, 74:9498-9506.
3. Agapov EV, Murray CL, Frolov I, Qu L, Myers TM, Rice CM: Uncleaved NS2-3 is required for production of infectious bovine viral diarrhea virus. J Virol 2004, 78:2414-2425.
4. Elbers K, Tautz N, Becher P, Stoll D, Rumenapf T, Thiel HJ: Processing in the pestivirus E2-NS2 region: identification of proteins p7 and E2p7. J Virol 1996, 70:4131-4135.
5. Lackner T, Thiel HJ, Tautz N: Dissection of a viral autoprotease elucidates a function of a cellular chaperone in proteolysis. Proc Natl Acad Sci USA 2006, 103:1510-1515.
6. Moulin HR, Seuberlich T, Bauhofer O, Bennett LC, Tratschin JD, Hofmann MA, Ruggli N: Nonstructural proteins NS2-3 and NS4A of classical swine fever virus: essential features for infectious particle formation. Virology 2007, 365:376-389.
7. Yang XJ, Liu J, Ye L, Liao QJ, Wu JG, Gao JR, She YL, Wu ZH, Ye LB: HCV NS2 protein inhibits cell proliferation and induces cell cycle arrest in the S-phase in mammalian cells through down-regulation of cyclin A expression. Virus Res 2006, 121:134-143.
8. Kudoh A, Fujita M, Kiyono T, Kuzushima K, Sugaya Y, Izuta S, Nishiyama Y, Tsurumi T: Reactivation of lytic replication from B cells latently infected with Epstein-Barr virus occurs with high S-phase cyclin-dependent kinase activity while inhibiting cellular DNA replication. J Virol 2003, 77:851-861.
9. Schang LM, Rosenberg A, Schaffer PA: Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins. J Virol 2000, 74:2107-2120.
10. Schang LM, Phillips J, Schaffer PA: Requirement for cellular cyclindependent kinases in herpes simplex virus replication and transcription. J Virol 1998, 72:5626-5637.
11. Liang MH, Geisbert T, Yao Y, Hinrichs SH, Giam CZ: Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis. J Virol 2002, 76:4022-4033.
12. Moennig V: The hog cholera virus. Comp Immunol Microbiol Infect Dis 1992, 15:189-201.
13. Hong HX, Zhang YM, Xu H, Su ZY, Sun P: Immortalization of swine umbilical vein endothelial cells with human telomerase reverse transcriptase. Mol Cells 2007, 24:358-363.
14. Das T, Sa G, Sinha P, Ray PK: Induction of cell proliferation and apoptosis: dependence on the dose of the inducer. Biochem Biophys Res Commun 1999, 260:105-110.
15. Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX, Harbour JW, Dean DC: Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 2000, 101:79-89.
16. Quinones QJ, de Ridder GG, Pizzo SV: GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum. Histol Histopathol 2008, 23:1409-1416.
17. Li J, Ni M, Lee B, Barron E, Hinton DR, Lee AS: The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ 2008, 15:1460-1471.
18. Lee AS: The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods 2005, 35:373-381.
19. Hong M, Lin MY, Huang JM, Baumeister P, Hakre S, Roy AL, Lee AS: Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation. J Biol Chem 2005, 280:16821-16828.
20. Yu Z, Luo H, Fu W, Mattson MP: The endoplasmic reticulum stressresponsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp Neurol 1999, 155:302-314.
21. Laitusis AL, Brostrom MA, Brostrom CO: The dynamic role of GRP78/BiP in the coordination of mRNA translation with protein processing. J Biol Chem 1999, 274:486-493.
22. Lackner T, Muller A, Pankraz A, Becher P, Thiel HJ, Gorbalenya AE, Tautz N: Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus. J Virol 2004, 78:10765-10775.
23. Lackner T, Muller A, Konig M, Thiel HJ, Tautz N: Persistence of bovine viral diarrhea virus is determined by a cellular cofactor of a viral autoprotease. J Virol 2005, 79:9746-9755.
24. Yamaga AK, Ou JH: Membrane topology of the hepatitis C virus NS2 protein. J Biol Chem 2002, 277:33228-33234.
25. Bensaude E, Turner JL, Wakeley PR, Sweetman DA, Pardieu C, Drew TW, Wileman T, Powell PP: Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of longterm infection of porcine vascular endothelial cells. J Gen Virol 2004, 85:1029-1037.
26. Moradpour D, Penin F, Rice CM: Replication of hepatitis C virus. NATURE REVIEWS MICROBIOLOGY 2007, 5:453-463.
27. Anelli T, Sitia R: Protein quality control in the early secretory pathway. The EMBO Journal 2008, 27:315-327.
28. Bussche AVd, Li K, Dumoulin F, Zhou Y, Wands J, Li J: Activation of endoplasmic reticulum stress signaling by the hepatitis C virus NS2 protein in the context of HCV replication. Journal of Clinical Virology 2006, 36:s115-s116.
29. Schroder M, Kaufman RJ: ER stress and the unfolded protein response. Mutat Res 2005, 569:29-63.
30. Rao RV, Bredesen DE: Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol 2004, 16:653-662.
31. Friedlander R, Jarosch E, Urban J, Volkwein C, Sommer T: A regulatory link between ER-associated protein degradation and the unfolded-protein response. nature cell biology 2000, 2:379-384.