Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders

Journal of Translational Medicine

Volumn 8, Issue , 2010, Pages

  Buonaguro, Luigi ^a,f   Petrizzo, Annacarmen ^a   Tornesello, Marialina ^a   Napolitano, Maria ^a   Martorelli, Debora ^b   Castello, Giuseppe ^a   Beneduce, Gerardo ^a   De Renzo, Amalia ^c   Perrella, Oreste ^d   Romagnoli, Luca ^e   Sousa, Vitor ^e   De Re, Valli ^b   Dolcetti, Riccardo ^b   Buonaguro, Franco M ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d AO Dei Colli Hospital for Infectious Diseases D Cotugno   (Italy)

^e Areta International   (Italy)

^f UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN LIGHT CHAIN; RECOMBINANT PROTEIN; BIOLOGICAL MARKER; CYTOKINE; IMMUNOGLOBULIN IDIOTYPE; LYMPHOCYTE ANTIGEN RECEPTOR; VIRUS VACCINE;

ADAPTIVE IMMUNITY; ARTICLE; B LYMPHOCYTE; CELL CLONING; CELL ISOLATION; CELL MATURATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYOGLOBULINEMIA; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG ACTIVITY; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNIZATION; INNATE IMMUNITY; LYMPHOPROLIFERATIVE DISEASE; MALE; NONHODGKIN LYMPHOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN ANALYSIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; HEPATITIS C; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY; VIROLOGY;

ADAPTIVE IMMUNITY; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CELLS, CULTURED; CYTOKINES; HEPACIVIRUS; HEPATITIS C; HUMANS; IMMUNITY, INNATE; IMMUNOGLOBULIN IDIOTYPES; IMMUNOGLOBULIN VARIABLE REGION; LEUKOCYTES, MONONUCLEAR; LYMPHOPROLIFERATIVE DISORDERS; PHENOTYPE; RECEPTORS, ANTIGEN, B-CELL; VIRAL VACCINES;

EID: 77649297470     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-8-18     Document Type: Article

References (44)

1. Moradpour D, Blum HE. Pathogenesis of hepatocellular carcinoma. Eur J Gastroenterol Hepatol 2005, 17:477-483. 10.1097/00042737-200505000-00002, 15827436.
2. Ferri C, Caracciolo F, Zignego AL, La CL, Monti M, Longombardo G, Lombardini F, Greco F, Capochiani E, Mazzoni A. Hepatitis C virus infection in patients with non-Hodgkin's lymphoma. Br J Haematol 1994, 88:392-394. 10.1111/j.1365-2141.1994.tb05036.x, 7803287.
3. Ferri C, Longombardo G, La CL, Greco F, Lombardini F, Cecchetti R, Cagianelli MA, Marchi S, Monti M, Zignego AL. Hepatitis C virus chronic infection as a common cause of mixed cryoglobulinaemia and autoimmune liver disease. J Intern Med 1994, 236:31-36. 10.1111/j.1365-2796.1994.tb01116.x, 8021570.
4. Zuckerman E, Zuckerman T, Levine AM, Douer D, Gutekunst K, Mizokami M, Qian DG, Velankar M, Nathwani BN, Fong TL. Hepatitis C virus infection in patients with B-cell non-Hodgkin lymphoma. Ann Intern Med 1997, 127:423-428.
5. De Re V, Caggiari L, Simula MP, De VS, Sansonno D, Dolcetti R. B-cell lymphomas associated with HCV infection. Gastroenterology 2007, 132:1205-1207. 10.1053/j.gastro.2007.02.009, 17383452.
6. Sansonno D, De VS, Cornacchiulo V, Carbone A, Boiocchi M, Dammacco F. Detection and distribution of hepatitis C virus-related proteins in lymph nodes of patients with type II mixed cryoglobulinemia and neoplastic or non-neoplastic lymphoproliferation. Blood 1996, 88:4638-4645.
7. Ferri C, Monti M, La CL, Longombardo G, Greco F, Pasero G, Gentilini P, Bombardieri S, Zignego AL. Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia. Blood 1993, 82:3701-3704.
8. Misiani R, Bellavita P, Fenili D, Borelli G, Marchesi D, Massazza M, Vendramin G, Comotti B, Tanzi E, Scudeller G. Hepatitis C virus infection in patients with essential mixed cryoglobulinemia. Ann Intern Med 1992, 117:573-577.
9. Zignego AL, Giannini C, Ferri C. Hepatitis C virus-related lymphoproliferative disorders: an overview. World J Gastroenterol 2007, 13:2467-2478.
10. Antonelli A, Ferri C, Galeazzi M, Giannitti C, Manno D, Mieli-Vergani G, Menegatti E, Olivieri I, Puoti M, Palazzi C, Roccatello D, Vergani D, Sarzi-Puttini P, Atzeni F. HCV infection: pathogenesis, clinical manifestations and therapy. Clin Exp Rheumatol 2008, 26:S39-S47.
11. Dammacco F, Sansonno D. Mixed cryoglobulinemia as a model of systemic vasculitis. Clin Rev Allergy Immunol 1997, 15:97-119. 10.1007/BF02828280, 9209804.
12. Martyak LA, Yeganeh M, Saab S. Hepatitis C and lymphoproliferative disorders: from mixed cryoglobulinemia to non-Hodgkin's lymphoma. Clin Gastroenterol Hepatol 2009, 7:900-905. 10.1016/j.cgh.2009.03.035, 19362606.
13. Pileri P, Uematsu Y, Campagnoli S, Galli G, Falugi F, Petracca R, Weiner AJ, Houghton M, Rosa D, Grandi G, Abrignani S. Binding of hepatitis C virus to CD81. Science 1998, 282:938-941. 10.1126/science.282.5390.938, 9794763.
14. Zignego AL, Ferri C, Giannelli F, Giannini C, Caini P, Monti M, Marrocchi ME, Di PE, La VG, Laffi G, Gentilini P. Prevalence of bcl-2 rearrangement in patients with hepatitis C virus-related mixed cryoglobulinemia with or without B-cell lymphomas. Ann Intern Med 2002, 137:571-580.
15. Machida K, Cheng KT, Sung VM, Shimodaira S, Lindsay KL, Levine AM, Lai MY, Lai MM. Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes. Proc Natl Acad Sci USA 2004, 101:4262-4267. 10.1073/pnas.0303971101, 384729, 14999097.
16. De Re V, De Vita S, Marzotto A, Rupolo M, Gloghini A, Pivetta B, Gasparotto D, Carbone A, Boiocchi M. Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia. Blood 2000, 96:3578-3584.
17. Perotti M, Ghidoli N, Altara R, Diotti RA, Clementi N, De MD, Sassi M, Clementi M, Burioni R, Mancini N. Hepatitis C virus (HCV)-driven stimulation of subfamily-restricted natural IgM antibodies in mixed cryoglobulinemia. Autoimmun Rev 2008, 7:468-472. 10.1016/j.autrev.2008.03.008, 18558364.
18. Charles ED, Green RM, Marukian S, Talal AH, Lake-Bakaar GV, Jacobson IM, Rice CM, Dustin LB. Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia. Blood 2008, 111:1344-1356. 10.1182/blood-2007-07-101717, 2214737, 17942751.
19. De Re V, De Vita S, Marzotto A, Gloghini A, Pivetta B, Gasparotto D, Cannizzaro R, Carbone A, Boiocchi M. Pre-malignant and malignant lymphoproliferations in an HCV-infected type II mixed cryoglobulinemic patient are sequential phases of an antigen-driven pathological process. Int J Cancer 2000, 87:211-216. 10.1002/1097-0215(20000715)87:2<211::AID-IJC9>3.0.CO;2-8, 10861476.
20. De Re V, Simula MP, Pavan A, Garziera M, Marin D, Dolcetti R, De VS, Sansonno D, Geremia S, Toffoli G. Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations. Ann N Y Acad Sci 2009, 1173:152-160. 10.1111/j.1749-6632.2009.04677.x, 19758144.
21. Bendandi M. Idiotype vaccines for lymphoma: proof-of-principles and clinical trial failures. Nat Rev Cancer 2009, 9:675-681. 10.1038/nrc2717, 19701243.
22. Buonaguro L, Monaco A, Arico E, Wang E, Tornesello ML, Lewis GK, Marincola FM, Buonaguro FM. Gene expression profile of peripheral blood mononuclear cells in response to HIV-VLPs stimulation. BMC Bioinformatics 2008, 9(Suppl 2):S5. 10.1186/1471-2105-9-S2-S5, 2323668, 18387207.
23. Aricò E, Wang E, Tornesello ML, Tagliamonte M, Lewis GK, Marincola FM, Buonaguro FM, Buonaguro L. Immature monocyte derived dendritic cells gene expression profile in response to Virus-Like Particles stimulation. J Transl Med 2005, 3:45. 10.1186/1479-5876-3-45, 1360684, 16384534.
24. Buonaguro L, Tornesello ML, Tagliamonte M, Gallo RC, Wang LX, Kamin-Lewis R, Abdelwahab S, Lewis GK, Buonaguro FM. Baculovirus-derived human immunodeficiency virus type 1 virus-like particles activate dendritic cells and induce ex vivo T-cell responses. J Virol 2006, 80:9134-9143. 10.1128/JVI.00050-06, 1563937, 16940524.
25. Buonaguro L, Tornesello ML, Gallo RC, Marincola FM, Lewis GK, Buonaguro FM. Th2 Polarization in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus (HIV)-Infected Subjects, as Activated by HIV Virus-Like Particles. J Virol 2009, 83:304-313. 10.1128/JVI.01606-08, 2612330, 18945779.
26. Monaco A, Marincola FM, Sabatino M, Pos Z, Tornesello ML, Stroncek DF, Wang E, Lewis GK, Buonaguro FM, Buonaguro L. Molecular immune signatures of HIV-1 vaccines in human PBMCs. FEBS Lett 2009, 583:3004-3008. 10.1016/j.febslet.2009.07.060, 19665024.
27. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony- stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994, 179:1109-1118. 10.1084/jem.179.4.1109, 2191432, 8145033.
28. Querec TD, Akondy RS, Lee EK, Cao W, Nakaya HI, Teuwen D, Pirani A, Gernert K, Deng J, Marzolf B, Kennedy K, Wu H, Bennouna S, Oluoch H, Miller J, Vencio RZ, Mulligan M, Aderem A, Ahmed R, Pulendran B. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat Immunol 2009, 10:116-125. 10.1038/ni.1688, 19029902.
29. Gaucher D, Therrien R, Kettaf N, Angermann BR, Boucher G, Filali-Mouhim A, Moser JM, Mehta RS, Drake DR, Castro E, Akondy R, Rinfret A, Yassine-Diab B, Said EA, Chouikh Y, Cameron MJ, Clum R, Kelvin D, Somogyi R, Greller LD, Balderas RS, Wilkinson P, Pantaleo G, Tartaglia J, Haddad EK, Sekaly RP. Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses. J Exp Med 2008, 205:3119-3131. 10.1084/jem.20082292, 2605227, 19047440.
30. Chougnet C, Cohen SS, Kawamura T, Landay AL, Kessler HA, Thomas E, Blauvelt A, Shearer GM. Normal immune function of monocyte-derived dendritic cells from HIV-infected individuals: implications for immunotherapy. J Immunol 1999, 163:1666-1673.
31. Fan Z, Huang XL, Kalinski P, Young S, Rinaldo CR. Dendritic cell function during chronic hepatitis C virus and human immunodeficiency virus type 1 infection. Clin Vaccine Immunol 2007, 14:1127-1137. 10.1128/CVI.00141-07, 2043301, 17634507.
32. Huang XL, Fan Z, Colleton BA, Buchli R, Li H, Hildebrand WH, Rinaldo CR. Processing and presentation of exogenous HLA class I peptides by dendritic cells from human immunodeficiency virus type 1-infected persons. J Virol 2005, 79:3052-3062. 10.1128/JVI.79.5.3052-3062.2005, 548465, 15709025.
33. Longman RS, Talal AH, Jacobson IM, Rice CM, Albert ML. Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C. J Infect Dis 2005, 192:497-503. 10.1086/431523, 15995965.
34. Piccioli D, Tavarini S, Nuti S, Colombatto P, Brunetto M, Bonino F, Ciccorossi P, Zorat F, Pozzato G, Comar C, Abrignani S, Wack A. Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors. J Hepatol 2005, 42:61-67. 10.1016/j.jhep.2004.09.014, 15629508.
35. Stebbing J, Patterson S, Portsmouth S, Thomas C, Glassman R, Wildfire A, Gotch F, Bower M, Nelson M, Gazzard B. Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients. Cell Res 2004, 14:251-256. 10.1038/sj.cr.7290226, 15225419.
36. Spanakis NE, Garinis GA, Alexopoulos EC, Patrinos GP, Menounos PG, Sklavounou A, Manolis EN, Gorgoulis VG, Valis D. Cytokine serum levels in patients with chronic HCV infection. J Clin Lab Anal 2002, 16:40-46. 10.1002/jcla.2060, 11835530.
37. Abayli B, Canataroglu A, Akkiz H. Serum profile of T helper 1 and T helper 2 cytokines in patients with chronic hepatitis C virus infection. Turk J Gastroenterol 2003, 14:7-11.
38. Fan XG, Liu WE, Li CZ, Wang ZC, Luo LX, Tan DM, Hu GL, Zhang Z. Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection. Mediators Inflamm 1998, 7:295-297. 10.1080/09629359890992, 1781851, 9792341.
39. Reiser M, Marousis CG, Nelson DR, Lauer G, Gonzalez-Peralta RP, Davis GL, Lau JY. Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection. J Hepatol 1997, 26:471-478. 10.1016/S0168-8278(97)80409-6, 9075651.
40. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993, 178:1041-1048. 10.1084/jem.178.3.1041, 2191152, 8102388.
41. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989, 170:827-845. 10.1084/jem.170.3.827, 2189443, 2504877.
42. Kubin M, Kamoun M, Trinchieri G. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J Exp Med 1994, 180:211-222. 10.1084/jem.180.1.211, 2191554, 7516408.
43. Murphy EE, Terres G, Macatonia SE, Hsieh CS, Mattson J, Lanier L, Wysocka M, Trinchieri G, Murphy K, O'Garra A. B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation. J Exp Med 1994, 180:223-231. 10.1084/jem.180.1.223, 2191551, 7516409.
44. Buonaguro L, Tornesello ML, Jewis GK, Buonaguro FM. Short communication: limited induction of IL-10 in PBMCs from HIV-infected subjects treated with HIV-VLPs. AIDS Res Hum Retroviruses 2009, 25:819-822. 10.1089/aid.2008.0304, 19630502.