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Volumn 11, Issue , 2010, Pages

Integrin-linked kinase functions as a downstream signal of platelet-derived growth factor to regulate actin polymerization and vascular smooth muscle cell migration

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN LINKED KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PLATELET DERIVED GROWTH FACTOR; SMALL INTERFERING RNA; ACTIN; INTEGRIN-LINKED KINASE; PROTEIN SERINE THREONINE KINASE;

EID: 77649296147     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-11-16     Document Type: Article
Times cited : (21)

References (43)
  • 1
    • 0031456015 scopus 로고    scopus 로고
    • Smooth muscle migration in atherosclerosis and restenosis
    • Schwartz SM. Smooth muscle migration in atherosclerosis and restenosis. Journal of Clinical Investigation 1997, 100(11 Suppl):S87-89.
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.11 SUPPL
    • Schwartz, S.M.1
  • 2
    • 11144313064 scopus 로고    scopus 로고
    • Pathobiology of atherosclerosis--a brief review
    • Kher N, Marsh JD. Pathobiology of atherosclerosis--a brief review. Seminars in Thrombosis & Hemostasis 2004, 30(6):665-672.
    • (2004) Seminars in Thrombosis & Hemostasis , vol.30 , Issue.6 , pp. 665-672
    • Kher, N.1    Marsh, J.D.2
  • 3
    • 0025043810 scopus 로고
    • PDGF ligand and receptor gene expression during repair of arterial injury
    • 10.1083/jcb.111.5.2149, 2116329, 2172262
    • Majesky MW, Reidy MA, Bowen-Pope DF, Hart CE, Wilcox JN, Schwartz SM. PDGF ligand and receptor gene expression during repair of arterial injury. Journal of Cell Biology 1990, 111(5 Pt 1):2149-2158. 10.1083/jcb.111.5.2149, 2116329, 2172262.
    • (1990) Journal of Cell Biology , vol.111 , Issue.5 PART 1 , pp. 2149-2158
    • Majesky, M.W.1    Reidy, M.A.2    Bowen-Pope, D.F.3    Hart, C.E.4    Wilcox, J.N.5    Schwartz, S.M.6
  • 4
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: a perspective for the 1990s
    • 10.1038/362801a0, 8479518
    • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993, 362(6423):801-809. 10.1038/362801a0, 8479518.
    • (1993) Nature , vol.362 , Issue.6423 , pp. 801-809
    • Ross, R.1
  • 5
    • 34447250295 scopus 로고    scopus 로고
    • The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells
    • Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X. The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells. Biochemical & Biophysical Research Communications 2007, 360(2):433-436.
    • (2007) Biochemical & Biophysical Research Communications , vol.360 , Issue.2 , pp. 433-436
    • Chen, Y.1    Xu, H.2    Liu, J.3    Zhang, C.4    Leutz, A.5    Mo, X.6
  • 10
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiological Reviews 1999, 79(4):1283-1316.
    • (1999) Physiological Reviews , vol.79 , Issue.4 , pp. 1283-1316
    • Heldin, C.H.1    Westermark, B.2
  • 12
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • 10.1126/science.279.5350.509, 9438836
    • Hall A. Rho GTPases and the actin cytoskeleton. Science 1998, 279(5350):509-514. 10.1126/science.279.5350.509, 9438836.
    • (1998) Science , vol.279 , Issue.5350 , pp. 509-514
    • Hall, A.1
  • 13
    • 11244258882 scopus 로고    scopus 로고
    • Focal adhesion kinase: in command and control of cell motility
    • 10.1038/nrm1549, 15688067
    • Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nature Reviews Molecular Cell Biology 2005, 6(1):56-68. 10.1038/nrm1549, 15688067.
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.1 , pp. 56-68
    • Mitra, S.K.1    Hanson, D.A.2    Schlaepfer, D.D.3
  • 14
    • 0030026679 scopus 로고    scopus 로고
    • Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase
    • 10.1038/379091a0, 8538749
    • Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J, Bell JC, Dedhar S. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 1996, 379(6560):91-96. 10.1038/379091a0, 8538749.
    • (1996) Nature , vol.379 , Issue.6560 , pp. 91-96
    • Hannigan, G.E.1    Leung-Hagesteijn, C.2    Fitz-Gibbon, L.3    Coppolino, M.G.4    Radeva, G.5    Filmus, J.6    Bell, J.C.7    Dedhar, S.8
  • 15
    • 18844363699 scopus 로고    scopus 로고
    • ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling
    • 10.1038/sj.onc.1208525, 15735674
    • Qian Y, Zhong X, Flynn DC, Zheng JZ, Qiao M, Wu C, Dedhar S, Shi X, Jiang BH. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene 2005, 24(19):3154-3165. 10.1038/sj.onc.1208525, 15735674.
    • (2005) Oncogene , vol.24 , Issue.19 , pp. 3154-3165
    • Qian, Y.1    Zhong, X.2    Flynn, D.C.3    Zheng, J.Z.4    Qiao, M.5    Wu, C.6    Dedhar, S.7    Shi, X.8    Jiang, B.H.9
  • 16
    • 11144237626 scopus 로고    scopus 로고
    • The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner
    • 10.1074/jbc.M410051200, 15485819
    • Khyrul WA, LaLonde DP, Brown MC, Levinson H, Turner CE. The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner. Journal of Biological Chemistry 2004, 279(52):54131-54139. 10.1074/jbc.M410051200, 15485819.
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.52 , pp. 54131-54139
    • Khyrul, W.A.1    LaLonde, D.P.2    Brown, M.C.3    Levinson, H.4    Turner, C.E.5
  • 17
    • 26944439126 scopus 로고    scopus 로고
    • Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX
    • 10.1038/sj.onc.1208737, 15897874
    • Filipenko NR, Attwell S, Roskelley C, Dedhar S. Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. Oncogene 2005, 24(38):5837-5849. 10.1038/sj.onc.1208737, 15897874.
    • (2005) Oncogene , vol.24 , Issue.38 , pp. 5837-5849
    • Filipenko, N.R.1    Attwell, S.2    Roskelley, C.3    Dedhar, S.4
  • 18
    • 0027997094 scopus 로고
    • Platelet-derived growth factor-BB stimulates synthesis of the integrin alpha 2-subunit in human diploid fibroblasts
    • 10.1006/excr.1994.1351, 7526996
    • Ahlen K, Rubin K. Platelet-derived growth factor-BB stimulates synthesis of the integrin alpha 2-subunit in human diploid fibroblasts. Experimental Cell Research 1994, 215(2):347-353. 10.1006/excr.1994.1351, 7526996.
    • (1994) Experimental Cell Research , vol.215 , Issue.2 , pp. 347-353
    • Ahlen, K.1    Rubin, K.2
  • 19
    • 0028978783 scopus 로고
    • Induction of beta 1 integrin synthesis by recombinant platelet-derived growth factor (PDGF-AB) correlates with an enhanced migratory response of human dermal fibroblasts to various extracellular matrix proteins
    • 10.1006/excr.1995.1288, 7545130
    • Kirchberg K, Lange TS, Klein EC, Jungtaubl H, Heinen G, Meyer-Ingold W, Scharffetter-Kochanek K. Induction of beta 1 integrin synthesis by recombinant platelet-derived growth factor (PDGF-AB) correlates with an enhanced migratory response of human dermal fibroblasts to various extracellular matrix proteins. Experimental Cell Research 1995, 220(1):29-35. 10.1006/excr.1995.1288, 7545130.
    • (1995) Experimental Cell Research , vol.220 , Issue.1 , pp. 29-35
    • Kirchberg, K.1    Lange, T.S.2    Klein, E.C.3    Jungtaubl, H.4    Heinen, G.5    Meyer-Ingold, W.6    Scharffetter-Kochanek, K.7
  • 20
    • 0029670904 scopus 로고    scopus 로고
    • Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors
    • 10.1083/jcb.132.4.741, 2199872, 8647902
    • Sundberg C, Rubin K. Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors. Journal of Cell Biology 1996, 132(4):741-752. 10.1083/jcb.132.4.741, 2199872, 8647902.
    • (1996) Journal of Cell Biology , vol.132 , Issue.4 , pp. 741-752
    • Sundberg, C.1    Rubin, K.2
  • 21
    • 0032213801 scopus 로고    scopus 로고
    • Regulation of vascular smooth muscle migration by mitogen-activated protein kinase and calcium/calmodulin-dependent protein kinase II signaling pathways
    • Lundberg MS, Curto KA, Bilato C, Monticone RE, Crow MT. Regulation of vascular smooth muscle migration by mitogen-activated protein kinase and calcium/calmodulin-dependent protein kinase II signaling pathways. Journal of Molecular & Cellular Cardiology 1998, 30(11):2377-2389.
    • (1998) Journal of Molecular & Cellular Cardiology , vol.30 , Issue.11 , pp. 2377-2389
    • Lundberg, M.S.1    Curto, K.A.2    Bilato, C.3    Monticone, R.E.4    Crow, M.T.5
  • 22
    • 0033553558 scopus 로고    scopus 로고
    • Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
    • 10.1074/jbc.274.20.13954, 10318806
    • Matsumoto T, Yokote K, Tamura K, Takemoto M, Ueno H, Saito Y, Mori S. Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration. Journal of Biological Chemistry 1999, 274(20):13954-13960. 10.1074/jbc.274.20.13954, 10318806.
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.20 , pp. 13954-13960
    • Matsumoto, T.1    Yokote, K.2    Tamura, K.3    Takemoto, M.4    Ueno, H.5    Saito, Y.6    Mori, S.7
  • 24
    • 7244231301 scopus 로고    scopus 로고
    • MAP kinases and cell migration
    • 10.1242/jcs.01481, 15371522
    • Huang C, Jacobson K, Schaller MD. MAP kinases and cell migration. Journal of Cell Science 2004, 117(Pt 20):4619-4628. 10.1242/jcs.01481, 15371522.
    • (2004) Journal of Cell Science , vol.117 , Issue.PART 20 , pp. 4619-4628
    • Huang, C.1    Jacobson, K.2    Schaller, M.D.3
  • 26
    • 0026440702 scopus 로고
    • Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells
    • Koyama N, Morisaki N, Saito Y, Yoshida S. Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells. Journal of Biological Chemistry 1992, 267(32):22806-22812.
    • (1992) Journal of Biological Chemistry , vol.267 , Issue.32 , pp. 22806-22812
    • Koyama, N.1    Morisaki, N.2    Saito, Y.3    Yoshida, S.4
  • 27
    • 0026534274 scopus 로고
    • Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty
    • 10.1172/JCI115613, 442880, 1531345
    • Jawien A, Bowen-Pope DF, Lindner V, Schwartz SM, Clowes AW. Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. Journal of Clinical Investigation 1992, 89(2):507-511. 10.1172/JCI115613, 442880, 1531345.
    • (1992) Journal of Clinical Investigation , vol.89 , Issue.2 , pp. 507-511
    • Jawien, A.1    Bowen-Pope, D.F.2    Lindner, V.3    Schwartz, S.M.4    Clowes, A.W.5
  • 28
    • 0041423395 scopus 로고    scopus 로고
    • Chimera analysis supports a predominant role of PDGFRbeta in promoting smooth-muscle cell chemotaxis after arterial injury
    • 1868260, 12937138
    • Buetow BS, Tappan KA, Crosby JR, Seifert RA, Bowen-Pope DF. Chimera analysis supports a predominant role of PDGFRbeta in promoting smooth-muscle cell chemotaxis after arterial injury. American Journal of Pathology 2003, 163(3):979-984. 1868260, 12937138.
    • (2003) American Journal of Pathology , vol.163 , Issue.3 , pp. 979-984
    • Buetow, B.S.1    Tappan, K.A.2    Crosby, J.R.3    Seifert, R.A.4    Bowen-Pope, D.F.5
  • 29
    • 0033981817 scopus 로고    scopus 로고
    • Activation of integrin receptors is required for growth factor-induced smooth muscle cell dysfunction
    • 10.1016/S0741-5214(00)90167-8, 10664505
    • Mawatari K, Liu B, Kent KC. Activation of integrin receptors is required for growth factor-induced smooth muscle cell dysfunction. Journal of Vascular Surgery 2000, 31(2):375-381. 10.1016/S0741-5214(00)90167-8, 10664505.
    • (2000) Journal of Vascular Surgery , vol.31 , Issue.2 , pp. 375-381
    • Mawatari, K.1    Liu, B.2    Kent, K.C.3
  • 30
    • 0141756154 scopus 로고    scopus 로고
    • Interactions between growth factor receptors and adhesion molecules: breaking the rules
    • 10.1016/S0955-0674(03)00096-6, 14519391
    • Comoglio PM, Boccaccio C, Trusolino L. Interactions between growth factor receptors and adhesion molecules: breaking the rules. Current Opinion in Cell Biology 2003, 15(5):565-571. 10.1016/S0955-0674(03)00096-6, 14519391.
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.5 , pp. 565-571
    • Comoglio, P.M.1    Boccaccio, C.2    Trusolino, L.3
  • 31
    • 0033020670 scopus 로고    scopus 로고
    • The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
    • Tu Y, Li F, Goicoechea S, Wu C. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Molecular & Cellular Biology 1999, 19(3):2425-2434.
    • (1999) Molecular & Cellular Biology , vol.19 , Issue.3 , pp. 2425-2434
    • Tu, Y.1    Li, F.2    Goicoechea, S.3    Wu, C.4
  • 32
    • 0037330210 scopus 로고    scopus 로고
    • Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury
    • 10.1002/glia.10138, 12528177
    • Campana WM, Myers RR, Rearden A. Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury. GLIA 2003, 41(3):213-223. 10.1002/glia.10138, 12528177.
    • (2003) GLIA , vol.41 , Issue.3 , pp. 213-223
    • Campana, W.M.1    Myers, R.R.2    Rearden, A.3
  • 33
    • 0034702253 scopus 로고    scopus 로고
    • Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation
    • 10.1038/sj.onc.1203640, 10871859
    • Janji B, Melchior C, Vallar L, Kieffer N. Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. Oncogene 2000, 19(27):3069-3077. 10.1038/sj.onc.1203640, 10871859.
    • (2000) Oncogene , vol.19 , Issue.27 , pp. 3069-3077
    • Janji, B.1    Melchior, C.2    Vallar, L.3    Kieffer, N.4
  • 34
    • 11144225205 scopus 로고    scopus 로고
    • Integrin-linked kinase: a cancer therapeutic target unique among its ILK
    • 10.1038/nrc1524, 15630415
    • Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nature Reviews Cancer 2005, 5(1):51-63. 10.1038/nrc1524, 15630415.
    • (2005) Nature Reviews Cancer , vol.5 , Issue.1 , pp. 51-63
    • Hannigan, G.1    Troussard, A.A.2    Dedhar, S.3
  • 36
    • 46749109270 scopus 로고    scopus 로고
    • Integrin-linked kinase in the vascular smooth muscle cell response to injury
    • 10.2353/ajpath.2008.071046, 2438304, 18535176
    • Ho B, Hou G, Pickering JG, Hannigan G, Langille BL, Bendeck MP. Integrin-linked kinase in the vascular smooth muscle cell response to injury. American Journal of Pathology 2008, 173(1):278-288. 10.2353/ajpath.2008.071046, 2438304, 18535176.
    • (2008) American Journal of Pathology , vol.173 , Issue.1 , pp. 278-288
    • Ho, B.1    Hou, G.2    Pickering, J.G.3    Hannigan, G.4    Langille, B.L.5    Bendeck, M.P.6
  • 37
    • 42249111518 scopus 로고    scopus 로고
    • Regualtion of cell-matrix contacts and beta-catenin signaling in VSMC by integrin-linked kinase: implications for intimal thickening
    • 10.1007/s00395-007-0693-9, 18080083
    • Dwivedi A, Sala-Newby GB, George SJ. Regualtion of cell-matrix contacts and beta-catenin signaling in VSMC by integrin-linked kinase: implications for intimal thickening. Basic Res Cardiol 2008, 103(3):244-256. 10.1007/s00395-007-0693-9, 18080083.
    • (2008) Basic Res Cardiol , vol.103 , Issue.3 , pp. 244-256
    • Dwivedi, A.1    Sala-Newby, G.B.2    George, S.J.3
  • 38
    • 0035844879 scopus 로고    scopus 로고
    • A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction
    • 10.1083/jcb.153.6.1251, 2192033, 11402068
    • Yamaji S, Suzuki A, Sugiyama Y, Koide Y, Yoshida M, Kanamori H, Mohri H, Ohno S, Ishigatsubo Y. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. Journal of Cell Biology 2001, 153(6):1251-1264. 10.1083/jcb.153.6.1251, 2192033, 11402068.
    • (2001) Journal of Cell Biology , vol.153 , Issue.6 , pp. 1251-1264
    • Yamaji, S.1    Suzuki, A.2    Sugiyama, Y.3    Koide, Y.4    Yoshida, M.5    Kanamori, H.6    Mohri, H.7    Ohno, S.8    Ishigatsubo, Y.9
  • 39
    • 0035968234 scopus 로고    scopus 로고
    • Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions
    • 10.1074/jbc.M102163200, 11304546
    • Nikolopoulos SN, Turner CE. Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. Journal of Biological Chemistry 2001, 276(26):23499-23505. 10.1074/jbc.M102163200, 11304546.
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.26 , pp. 23499-23505
    • Nikolopoulos, S.N.1    Turner, C.E.2
  • 40
    • 0035399959 scopus 로고    scopus 로고
    • How is actin polymerization nucleated in vivo?
    • 10.1016/S0962-8924(01)02008-6, 11413039
    • Condeelis J. How is actin polymerization nucleated in vivo?. Trends in Cell Biology 2001, 11(7):288-293. 10.1016/S0962-8924(01)02008-6, 11413039.
    • (2001) Trends in Cell Biology , vol.11 , Issue.7 , pp. 288-293
    • Condeelis, J.1
  • 41
    • 0035903099 scopus 로고    scopus 로고
    • Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells
    • 10.1074/jbc.M102988200, 11418599
    • Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. Journal of Biological Chemistry 2001, 276(33):31449-31458. 10.1074/jbc.M102988200, 11418599.
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.33 , pp. 31449-31458
    • Toshima, J.1    Toshima, J.Y.2    Takeuchi, K.3    Mori, R.4    Mizuno, K.5
  • 42
    • 0032565962 scopus 로고    scopus 로고
    • Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase[see comment]
    • 10.1038/31729, 9655397
    • Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase[see comment]. Nature 1998, 393(6687):805-809. 10.1038/31729, 9655397.
    • (1998) Nature , vol.393 , Issue.6687 , pp. 805-809
    • Arber, S.1    Barbayannis, F.A.2    Hanser, H.3    Schneider, C.4    Stanyon, C.A.5    Bernard, O.6    Caroni, P.7
  • 43
    • 31544439674 scopus 로고    scopus 로고
    • Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival
    • 10.1158/0008-5472.CAN-05-2304, 16397254
    • Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, Gelmon KA, Kucab JE, Dunn SE, Emerman JT, Bally M, Dedhar S. Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer Research 2006, 66(1):393-403. 10.1158/0008-5472.CAN-05-2304, 16397254.
    • (2006) Cancer Research , vol.66 , Issue.1 , pp. 393-403
    • Troussard, A.A.1    McDonald, P.C.2    Wederell, E.D.3    Mawji, N.M.4    Filipenko, N.R.5    Gelmon, K.A.6    Kucab, J.E.7    Dunn, S.E.8    Emerman, J.T.9    Bally, M.10    Dedhar, S.11


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