Obsessive-compulsive disorder with poor insight: A three-year prospective study

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 34, Issue 2, 2010, Pages 323-330

  Catapano, Francesco ^a   Perris, Francesco ^a   Fabrazzo, Michele ^a   Cioffi, Valeria ^a   Giacco, Domenico ^a   De Santis, Valeria ^a   Maj, Mario ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Insight; Long term outcome; Obsessive compulsive disorder; Serotonin reuptake inhibitors

Indexed keywords

CITALOPRAM; CLOMIPRAMINE; FLUOXETINE; FLUVOXAMINE; HALOPERIDOL; IMIPRAMINE; MIRTAZAPINE; NEUROLEPTIC AGENT; PAROXETINE; PIMOZIDE; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; VENLAFAXINE;

ADOLESCENT; ADULT; ARTICLE; AUTISM; BROWN ASSESSMENT OF BELIEF SCALE; COMORBIDITY; DEPRESSION; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE ASSOCIATION; DISEASE SEVERITY; FAMILY HISTORY; FEMALE; FOLLOW UP; HUMAN; INTROSPECTION; MAJOR CLINICAL STUDY; MALE; OBSESSIVE COMPULSIVE DISORDER; ONSET AGE; OUTPATIENT; PROGNOSIS; PROSPECTIVE STUDY; PSYCHOLOGIC ASSESSMENT; RATING SCALE; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER;

ADULT; ANTISOCIAL PERSONALITY DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; OBSESSIVE-COMPULSIVE DISORDER; PERSONALITY ASSESSMENT; PSYCHIATRIC STATUS RATING SCALES; PSYCHOPATHOLOGY; RETROSPECTIVE STUDIES; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77649274856     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2009.12.007     Document Type: Article

References (70)

1. Aigner M., Zitterl W., Prayer D., Demal U., Bach M., Prayer L., et al. Magnetic resonance imaging in patients with obsessive-compulsive disorder with good versus poor insight. Psychiatry Res Neuroimaging 2005, 140:173-179.
2. Alonso P., Menchón J.M., Segalàs C., Jaurrieta N., Jiménez-Murcia S., Cardoner N., et al. Clinical implications of insight assessment in obsessive-compulsive disorder. Compr Psychiatry 2007, 49:305-312.
3. Andreasen N.C., Endicott J., Spitzer R.L., Winokur G. The family history method using diagnostic criteria. Reliability and validity. Arch Gen Psychiatry 1977, 34:1229-1235.
4. Baer L., Jenike M.A., Ricciardi J.N., Holland A.D., Seymour R.J., Minichiello W.E., et al. Standardized assessment of personality disorders in obsessive-compulsive disorder. Arch Gen Psychiatry 1990, 47:826-830.
5. Basoglu M., Lax T., Kasvikis Y., Marks I.M. Predictors of improvement in obsessive-compulsive disorder. J Anxiety Disord 1988, 2:299-317.
6. Bellino S., Patria L., Ziero S., Bogetto F. Clinical picture of obsessive-compulsive disorder with poor insight: a regression model. Psychiatry Res 2005, 136:223-231.
7. Bogetto F., Bellino S., Vaschetto P., Ziero S. Olanzapine augmentation of fluvoxamine-refractory obsessive-compulsive disorder (OCD): a 12-week open trial. Psychiatry Res 2000, 96:91-98.
8. Catapano F., Sperandeo R., Perris F., Lanzaro M., Maj M. Insight and resistance in patients with obsessive-compulsive disorder. Psychopathology 2001, 34:62-68.
9. Coles M.E., Pinto A., Mancebo M.C., Rasmussen S.A., Eisen J.L. OCD with comorbid OCPD: a subtype of OCD?. J Psychiatr Res 2007, 42:289-296.
10. De Berardis D., Campanella D., Gambi F., Sepede G., Salini G., Carano A., et al. Insight and alexithymia in adult outpatients with obsessive-compulsive disorder. Eur Arch Psych Clin Neurosci 2005, 255:350-358.
11. Eisen J.L., Rasmussen S.A. Obsessive-compulsive disorder with psychotic features. J Clin Psychiatry 1993, 54:373-379.
12. Eisen J.L., Steketee G. Course of illness in obsessive-compulsive disorder. OCD across the life cycle 1997, 73-95. American Psychiatric Press, Arlington. M.T. Pato, G. Steketee (Eds.).
13. Eisen J.L., Phillips K.A., Baer L., Beer D.A., Atala K.D., Rasmussen S.A. The Brown Assessment of Beliefs Scale - reliability and validity. Am J Psychiatry 1998, 155:102-108.
14. Eisen J.L., Goodman W.K., Keller M.B., Warshaw M.G., DeMarco L.M., Luce D.D., et al. Patterns of remission and relapse: in obsessive-compulsive disorder: a 2-year prospective study. J Clin Psychiatry 1999, 60:346-351.
15. Eisen J.L., Rasmussen S.A., Phillips K.A., Price L.H., Davidson J., Lydiard R.B., et al. Insight and treatment outcome in obsessive-compulsive disorder. Compr Psychiatry 2001, 42:494-497.
16. Erzegovesi S., Cavallini M.C., Cavedini P., Diaferia G., Locatelli M., Bellodi L. Clinical predictors of drug response in obsessive-compulsive disorder. J Clin Psychopharmacol 2001, 21:488-492.
17. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured clinical interview for DSM-IV axis I disorders, Patient Edition, version 2.0 (SCID-I/P). New York: New York State Psychiatric Institute, Biometrics Research, 1996.
18. First M.B., Gibbon M., Spitzer R.L., Williams J.B.W. Structured clinical interview for DSM-IV axis II personality disorders (SCID-II) 1997, American Psychiatric Press, Washington.
19. Foa E.B. Failure in treating obsessive-compulsives. Behav Res Ther 1979, 17:169-176.
20. Foa E.B., Franklin M.E. Psychotherapies for obsessive-compulsive disorder: a review. Obsessive-compulsive disorder 2002, 93-115. Wiley, Chichester. 2nd ed. M. Maj, N. Sartorius, A. Okasha, J. Zohar (Eds.).
21. Foa E.B., Kozak M.J., Goodman W.K., Hollander E., Jenike M.A., Rasmussen S.A. DSM-IV field trial: obsessive-compulsive disorder. Am J Psychiatry 1995, 152:90-96.
22. Foa E.B., Abramowitz J.S., Franklin M.E., Kozak M.J. Feared consequences, fixity of belief, and treatment outcome in patients with obsessive-compulsive disorder. Behav Ther 1999, 30:717-724.
23. Fontenelle L.F., Mendlowicz M.V., Marques C., Versiani M. Early- and late-onset obsessive-compulsive disorder in adult patients: an exploratory clinical and therapeutic study. J Psychiatr Res 2003, 37:127-133.
24. Fontenelle L.F., Mendlowicz M.V., Soares I.D., Versiani M. Patients with obsessive-compulsive disorder and hoarding symptoms: a distinct clinical subtype?. Compr Psychiatry 2004, 45:375-383.
25. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., et al. The Yale-Brown obsessive compulsive scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989, 46:1006-1011.
26. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960, 23:56-62.
27. Harris C.L., Dinn W.M. Subtyping obsessive-compulsive disorder: neuropsychological correlates. Behav Neurol 2003, 14:75-87.
28. Himle J.A., Van Etten M.L., Janeck A.S., Fischer D.J. Insight as a predictor of treatment outcome in behavioral group treatment for obsessive-compulsive disorder. Cogn Ther Res 2006, 30:661-666.
29. Huppert J.D., Franklin M.E. Cognitive behavioral therapy for obsessive-compulsive disorder: an update. Curr Psychiatry Rep 2005, 7:268-273.
30. Insel T.R., Akiskal H.S. Obsessive-compulsive disorder with psychotic features: a phenomenologic analysis. Am J Psychiatry 1986, 143:1527-1533.
31. Ito L.M., de Araujo L.A., Hemsley D., Marks I.M. Belief and resistance in obsessive-compulsive disorder: observation from a controlled study. J Anxiety Disord 1995, 167:71-75.
32. Jenike M.A., Baer L., Minichiello W.E., Schwartz C.E., Carey R.J. Concomitant obsessive-compulsive disorder and schizotypal personality disorder. Am J Psychiatry 1986, 143:530-532.
33. Joffe R.T., Swinson R.P., Regan J.J. Personality features of obsessive-compulsive disorder. Am J Psychiatry 1988, 145:1127-1129.
34. Kitis A., Akdede B.B., Alptekin K., Akvardar Y., Arkar H., Erol A., et al. Cognitive dysfunctions in patients with obsessive-compulsive disorder compared to the patients with schizophrenia patients: relation to overvalued ideas. Prog Neuropsychopharmacol Biol Psychiatry 2007, 31:254-261.
35. Kozak M.J., Foa E.B. Obsessions, overvalued ideas, and delusions in obsessive-compulsive disorder. Behav Res Ther 1994, 32:343-353.
36. Leckman J.F., Rauch S.L., Mataix-Cols D. Symptom dimensions in obsessive-compulsive disorder: implications for the DSM-V. CNS Spectr 2007, 12:376-387.
37. Lelliott P.T., Marks I.M. Management of obsessive-compulsive rituals associated with delusions, hallucinations and depression: a case report. Behav Psychother 1987, 15:77-87.
38. Lelliott P.T., Noshirvani H.F., Basoglu M., Marks I.M., Monteiro W.O. Obsessive-compulsive beliefs and treatment outcome. Psychol Med 1988, 18:697-702.
39. Lochner C., Stein D.J. Heterogeneity of obsessive-compulsive disorder: a literature review. Harv Rev Psychiatry 2003, 11:113-132.
40. Maina G., Albert U., Salvi V., Pessina E., Bogetto F. Early-onset obsessive-compulsive disorder and personality disorders in adulthood. Psychiatry Res 2008, 158:217-225.
41. Marazziti D., Dell'Osso L., Di Nasso E., Pfanner C., Presta S., Mungai F., et al. Insight in obsessive-compulsive disorder: a study of an Italian sample. Eur Psychiatry 2002, 17:407-410.
42. March J., Frances A., Kahn D., Carpenter D. Expert consensus guidelines: treatment of obsessive-compulsive disorder. J Clin Psychiatry 1997, 4:1-72.
43. Mataix-Cols D., Wooderson S., Lawrence N., Brammer M.J., Speckens A., Phillips M.L. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry 2004, 61:564-576.
44. Mathis M.A., Diniz J.B., do Rosário M.C., Torres A.R., Hoexter M., Hasler G., et al. What is the optimal way to subdivide obsessive-compulsive disorder?. CNS Spectr 2006, 11:762-779.
45. Matsunaga H., Kiriike N., Matsui T., Oya K., Iwasaki Y., Koshimune K., et al. Obsessive-compulsive disorder with poor insight. Compr Psychiatry 2002, 43:150-157.
46. McDougle C.J., Goodman W.K., Leckman J.F., Lee N.C., Heninger G.R., Price L.H. Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in patients with and without tics. Arch Gen Psychiatry 1994, 51:302-308.
47. Minichiello W.E., Baer L., Jenike M.A. Schizotypal personality disorder: a poor prognostic indicator for behaviour therapy in the treatment of obsessive-compulsive disorder. J Anxiety Disord 1987, 1:273-276.
48. Moritz S., Fricke S., Jacobsen D., Kloss M., Wein C., Rufer M., et al. Positive schizotypal symptoms predict treatment outcome in obsessive-compulsive disorder. Behav Res Ther 2004, 42:217-227.
49. Nestadt G., Addington A., Samuels J., Liang K.Y., Bienvenu O.J., Riddle M., et al. The identification of OCD-related subgroups based on comorbidity. Biol Psychiatry 2003, 53:914-920.
50. Orloff B.A., Battle M.A., Baer L., Ivanjack L., Pettit A.R., Buttolph L., et al. Long-term follow-up of 85 patients with obsessive-compulsive disorder. Am J Psychiatry 1994, 151:441-442.
51. Pallanti S., Quercioli L. Treatment-refractory obsessive-compulsive disorder: methodological issues, operational definitions and therapeutic lines. Prog Neuropsychopharmacol Biol Psychiatry 2006, 30:400-412.
52. Perugi G., Akiskal H.S., Gemignani A., Pfanner C., Presta S., Milanfranchi A., et al. Episodic course of obsessive-compulsive disorder. Eur Arch Psych Clin Neurosci 1998, 248:240-244.
53. Pigott T.A., L'Heureux F., Dubbert B., Bernstein S., Murphy D.L. Obsessive compulsive disorder: comorbid conditions. J Clin Psychiatry 1994, 55(Suppl):15-27.
54. Poyurovsky M., Koran L.M. Obsessive-compulsive disorder (OCD) with schizotypy vs. schizophrenia with OCD: diagnostic dilemmas and therapeutic implications. J Psychiatr Res 2005, 39:399-408.
55. Poyurovsky M., Faragian S., Pashinian A., Heidrach L., Fuchs C., Weizman R., et al. Clinical characteristics of schizotypal-related obsessive-compulsive disorder. Psychiatry Res 2008, 159:254-258.
56. Ravi Kishore V., Samar R., Janardhan Reddy Y.C., Chandrasekhar C.R., Thennarasu K. Clinical characteristics and treatment response in poor and good insight obsessive-compulsive disorder. Eur Psychiatry 2004, 19:202-208.
57. Ravizza L., Barzega G., Bellino S., Bogetto F., Maina G. Predictors of drug treatment response in obsessive-compulsive disorder. J Clin Psychiatry 1995, 56:368-373.
58. Ravizza L., Maina G., Bogetto F. Episodic and chronic obsessive-compulsive disorder. Depress Anxiety 1997, 6:154-158.
59. Reddy Y.C.J., D'Souza S.M., Shetti C., Kandavel T., Deshpande S., Badamath S., et al. An 11- to 13- year follow-up of 75 subjects with obsessive-compulsive disorder. J Clin Psychiatry 2005, 66:744-749.
60. Rosario-Campos M.C., Leckman J.F., Mercadante M.T., Shavitt R.G., Prado H.S., Sada P., et al. Adults with early-onset obsessive-compulsive disorder. Am J Psychiatry 2001, 158:1899-1903.
61. Salkovskis P.M. Obsessional-compulsive problems: a cognitive-behavioural analysis. Behav Res Ther 1985, 23:571-583.
62. Shin N.Y., Lee A.R., Park H.Y., Yoo S.Y., Kang D.H., Shin M.S., et al. Impact of coexistent schizotypal personality traits on frontal lobe function in obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2008, 32:472-478.
63. Sobin C., Blundell M.L., Weiller F., Gavigan C., Haiman C., Karayiorgou M. Evidence of a schizotypy subtype in OCD. J Psychiatr Res 2000, 34:15-24.
64. Solyom L., DiNicola V.F., Phil M., Sookman D., Luchins D. Is there an obsessive psychosis? Aetiological and prognostic factors of an atypical form of obsessive-compulsive neurosis. Can J Psychiatry 1985, 30:372-380.
65. Stanley M.A., Turner S.M., Borden J.W. Schizotypal features in obsessive-compulsive disorder. Compr Psychiatry 1990, 31:511-518.
66. Steketee G., Eisen J., Dyck I., Warshaw M., Rasmussen S. Predictors of course in obsessive-compulsive disorder. Psychiatry Res 1999, 89:229-238.
67. Storch E.A., Milsom V.A., Merlo L.J., Larson M., Geffken G.R., Jacob M.L., et al. Insight in pediatric obsessive-compulsive disorder: associations with clinical presentation. Psychiatry Res 2008, 160:212-220.
68. Tumkaya S., Karadag F., Oguzhanoglu N.K., Tekkanat C., Varma G., Ozdel O., et al. Schizophrenia with obsessive-compulsive disorder and obsessive-compulsive disorder with poor insight: a neuropsychological comparison. Psychiatry Res 2009, 165:38-46.
69. Türksoy N., Tükel R., Özdemir O., Karali A. Comparison of clinical characteristics in good and poor insight obsessive-compulsive disorder. J Anxiety Disord 2002, 16:413-423.
70. van Oppen P., van Balkom A.J., de Haan E., van Dyck R. Cognitive therapy and exposure in vivo alone and in combination with fluvoxamine in obsessive-compulsive disorder: a 5-year follow-up. J Clin Psychiatry 2005, 66:1415-1422.