Taking a load off: Nuclear remodeling after mechanically supporting the failing human heart

Circulation

Volumn 121, Issue 8, 2010, Pages 957-959

  Murry, Charles E ^a   Kühn, Bernhard ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA SYNTHESIS; EDITORIAL; HEART ASSIST DEVICE; HEART FAILURE; HEART MUSCLE CELL; HEART STRESS; HUMAN; MECHANICAL STRESS; PRIORITY JOURNAL;

DNA; HEART FAILURE; HEART-ASSIST DEVICES; HUMANS; MYOCYTES, CARDIAC; PLOIDIES; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 77649262299     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIR.0b013e3181d61b63     Document Type: Editorial

References (17)

1. Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intra-cellular signalling pathways. Nat Rev Mol Cell Biol. 2006;7:589-600.
2. Adler CP, Friedburg H. Myocardial DNA content, ploidy level and cell number in geriatric hearts: post-mortem examinations of human myocardium in old age. J Mol Cell Cardiol. 1986;18:39-53.
3. Soonpaa MH, Field LJ. Survey of studies examining mammalian cardio-myocyte DNA synthesis. Circ Res. 1998;83:15-26.
4. Edgar BA, Orr-Weaver TL. Endoreplication cell cycles: more for less. Cell. 2001;105:297-306.
5. Wohlschläger J, Levkau B, Brockhoff G, Schmitz KJ, von Winterfeld M, Takeda A, Takeda N, Stypmann J, Valhaus C, Schmid C, Pomjanski N, Bocking A, Baba HA. Hemodynamic support by left ventricular assist devices reduces cardiomyocyte DNA content in the failing human heart. Circulation. 2010;121:989-996.
6. Dipla K, Mattiello JA, Jeevanandam V, Houser SR, Margulies KB. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. Circulation. 1998;97:2316-2322.
7. Zafeiridis A, Jeevanandam V, Houser SR, Margulies KB. Regression of cellular hypertrophy after left ventricular assist device support. Circulation. 1998;98:656-662.
8. Maybaum S, Mancini D, Xydas S, Starling RC, Aaronson K, Pagani FD, Miller LW, Margulies K, McRee S, Frazier OH, Torre-Amione G. Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group. Circulation. 2007;115:2497-2505.
9. Heerdt PM, Holmes JW, Cai B, Barbone A, Madigan JD, Reiken S, Lee DL, Oz MC, Marks AR, Burkhoff D. Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure. Circulation. 2000;102:2713-2719.
10. George RS, Yacoub MH, Bowles CT, Hipkin M, Rogers P, Hallas C, Banner NR, Dreyfus G, Khaghani A, Birks EJ. Quality of life after removal of left ventricular assist device for myocardial recovery. J Heart Lung Transplant. 2008;27:165-172.
11. Schneider R, Pfitzer P. Number of nuclei in isolated human myocardial cells [in German]. Virchows Arch B Cell Pathol. 1973;12:238-258.
12. Olivetti G, Cigola E, Maestri R, Corradi D, Lagrasta C, Gambert SR, Anversa P. Aging, cardiac hypertrophy and ischemic cardiomyopathy do not affect the proportion of mononucleated and multinucleated myocytes in the human heart. J Mol Cell Cardiol. 1996;28:1463-1477.
13. Tea BS, Dam TV, Moreau P, Hamet P, deBlois D. Apoptosis during regression of cardiac hypertrophy in spontaneously hypertensive rats: temporal regulation and spatial heterogeneity. Hypertension. 1999;34: 229-235.
14. Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisen J. Evidence for cardiomyocyte renewal in humans. Science. 2009;324: 98-102.
15. Bersell K, Arab S, Haring B, Kuhn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009;138:257-270.
16. Beltrami AP, Urbanek K, Kajstura J, Yan SM, Finato N, Bussani R, Nadal-Ginard B, Silvestri F, Leri A, Beltrami CA, Anversa P. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med. 2001;344:1750-1757.
17. Hsieh PC, Segers VF, Davis ME, Macgillivray C, Gannon J, Molkentin JD, Robbins J, Lee RT. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med. 2007;13:970-974.