Challenging small human hepatocytes with opiates: Further characterization of a novel prototype bioartificial liver

Tissue Engineering - Part A

Volumn 16, Issue 3, 2010, Pages 807-813

  Wurm, Martin ^a   Woess, Claudia ^a   Libiseller, Kathrin ^a   Beer, Beate ^a   Pavlic, Marion ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOLOGICAL MATERIALS PRESERVATION; CHROMATOGRAPHIC ANALYSIS; CONFOCAL MICROSCOPY; DRUG THERAPY; GAS CHROMATOGRAPHY; GENE EXPRESSION; GLUCOSE; LIVER; MASS SPECTROMETRY; METABOLISM; RATE CONSTANTS; UREA;

ANTICANCER TREATMENT; BIOARTIFICIAL LIVER; CELL DENSITY; CELL VIABILITY; DRUG ABUSE; FIRST ORDER KINETICS; FIRST-ORDER RATE CONSTANTS; GLUCOSE CONSUMPTION; HUMAN HEPATOCYTES; LACTATE DEHYDROGENASE; LIVER FAILURE; METABOLIC ACTIVITY; STRESS FACTORS; UREA PRODUCTION; WESTERN BLOTS;

CELL CULTURE;

CELL EXTRACT; METHADONE; MORPHINE; OPIATE;

ARTICLE; ARTIFICIAL LIVER; CELL COUNT; CELL CULTURE; CELL SURVIVAL; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; HUMAN; LIVER CELL; METABOLISM; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL COUNT; CELL CULTURE TECHNIQUES; CELL EXTRACTS; CELL SURVIVAL; CELLS, CULTURED; HEPATOCYTES; HUMANS; LIVER, ARTIFICIAL; METHADONE; MORPHINE; OPIATE ALKALOIDS;

EID: 77649254603     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0420     Document Type: Article

References (35)

1. Millis, J.M., and Losanoff, J.E. Technology insight: liver support systems. Nat Clin Pract Gastroenterol Hepatol 2, 398, 2005.
2. Cook, P.A., McVeigh, J., Syecl, Q., Mutton, K., and Bellis, M.A. Predictors of hepatitis B and C infection in injecting drug users both in and out of drug treatment. Addiction 96, 1787, 2001.
3. Schuppan, D., Krebs, A., Bauer, M., and Hahn, E.G. Hepatitis C and liver fibrosis. Cell Death Differ 10 Suppl 1, 59, 2003.
4. Ferri, C, La, C.L., Zignego, A.L., and Pasero, G. Viruses and cancers: possible role of hepatitis C virus. Eur J Clin Investig 27, 711, 1997.
5. Angermayr, B., Luca, A., Konig, F., Bertolini, G., Ploner, M., Gridelli, B., Ulbrich, G., Reiberger, T., Bosch, J., and Peck-Radosavljevic, M. Aetiology of cirrhosis of the liver has an impact on survival predicted by the model of end-stage liver disease score. Eur J Clin Investig 39, 65, 2009.
6. Forman, L.M. To transplant or not to transplant recurrent hepatitis C and liver failure. Clin Liver Dis 7, 615, 2003.
7. Falkenhagen, D., Strobl, W., Vogt, G., Schrefl, A., Linsberger, I., Gerner, F.J., and Schoenhofen, M. Fractionated plasma separation and adsorption system: a novel system for blood purification to remove albumin bound substances. Artif Organs 23, 81, 1999.
8. Rifai, K., Ernst, T., Kretschmer, U., Bahr, M.J., Schneider, A., Hafer, C, Haller, H., Manns, M.P., and Fliser, D. Prometheus\a new extracorporeal system for the treatment of liver failure. J Hepatol 39, 984, 2003.
9. Dixit, V., and Gitnick, G. The bioartificial liver: state-of-the-art. Eur J Surg Suppl 582, 71, 1998.
10. Kataropoulou, M., Henderson, C., and Grant, M.H. Metabolic studies of hepatocytes cultured on collagen substrata modified to contain glycosaminoglycans. Tissue Eng 11, 1263, 2005.
11. Wolf, C.F., and Munkelt, B.E. Bilirubin conjugation by an artificial liver composed of cultured cells and synthetic capillaries. Trans Am Soc Artif Intern Organs 21, 16, 1975.
12. Kobayashi, N., Okitsu, T., and Tanaka, N. Cell choice for bioartificial livers. Keio J Med 52, 151, 2003.
13. Hochleitner, B., Hengster, P., Duo, L., Bucher, H., Klima, G., and Margreiter, R. A novel bioartificial liver with culture of porcine hepatocyte aggregates under simulated microgravity. Artif Organs 29, 58, 2005.
14. Miskon, A., Yamaoka, T., Hyon, S.H., Kodama, M., and Uyama, H. Preservation of porcine hepatocytes in three-dimensional bioreactor at room temperature using epigallocatechin-3-gallate. Tissue Eng Part C 15, 345, 2009.
15. Martina, Y., Marcucci, K.T., Cherqui, S., Szabo, A., Drysdale, T., Srinivisan, U., Wilson, C.A., Patience, C., and Salomon, D.R. Mice transgenic for a human porcine endogenous retrovirus receptor are susceptible to productive viral infection. J Virol 80, 3135, 2006.
16. Mitaka, T., Sattler, G.L., Pitot, H.C., and Mochizuki, Y. Characteristics of small cell colonies developing in primary cultures of adult rat hepatocytes. Virchows Arch B Cell Pathol Incl Mol Pathol 62, 329, 1992.
17. Shibata, C, Mizuguchi, T., Kikkawa, Y., Nobuoka, T., Oshima, H., Kawasaki, H., Kawamoto, M., Katsuramaki, T., Mitaka, T., and Hirata, K. Liver repopulation and long-term function of rat small hepatocyte transplantation as an alternative cell source for hepatocyte transplantation. Liver Transpl 12, 78, 2006.
18. Pavlic, M., Libiseller, K., Hermann, M., Hengster, P., Margreiter, R., and Wurm, M. Small human hepatocytes in rotary culture for treatment of alcohol addicts? A pilot study. Alcohol Clin Exp Res 31, 729, 2007.
19. Wurm, M., Lubei, V., Caronna, M., Hermann, M., Margreiter, R., and Hengster, P. Development of a novel perfused rotary cell culture system. Tissue Eng 13, 2761, 2007.
20. Ahmadi, J., Ahmadi, K., and Ohaeri, J. Controlled, randomized trial in maintenance treatment of intravenous bu-prenorphine dependence with naltrexone, methadone or buprenorphine: a novel study. Eur J Clin Investig 33, 824, 2003.
21. McCarthy, J. Quantitative urine drug monitoring in methadone programs: potential clinical uses. J Psychoactive Drugs 26, 199, 1994.
22. Fugelstad, A., Stenbacka, M., Leifman, A., Nylander, M., and Thiblin, I. Methadone maintenance treatment: the balance between life-saving treatment and fatal poisonings. Addiction 102, 406, 2007.
23. Kraigher, D., Jagsch, R., Gombas, W., Ortner, R., Eder, H., Primorac, A., and Fischer, G. Use of slow-release oral morphine for the treatment of opioid dependence. Eur Addict Res 11, 145, 2005.
24. Friesen, C, Roscher, M., Alt, A., and Miltner, E. Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance. Cancer Res 68, 6059, 2008.
25. Mitaka, T., Kojima, T., Mizuguchi, T., and Mochizuki, Y. Growth and maturation of small hepatocytes isolated from adult rat liver. Biochem Biophys Res Commun 214,310,1995.
26. Wurm, M., Lubei, V., Caronna, M., Hermann, M., Buttiglieri, S., Bodamer, O., Muhl, A., Tetta, C, Margreiter, R., and Hengster, P. Introduction of a novel prototype BAL support system utilizing small human hepatocytes (SH) in rotary culture. Tissue Eng Part A 15, 1063, 2009.
27. Patzer, J.F., Campbell, B., and Miller, R. Plasma versus whole blood perfusion in a bioartificial liver assist device. ASAIO J 48, 226, 2002.
28. Stange, J., Mitzner, S.R., Risler, T., Erley, CM., Lauchart, W., Goehl, H., Klammt, S., Peszynski, P., Freytag, J., Hickstein, H., Lohr, M., Liebe, S., Schareck, W., Hopt, U.T., and Schmidt, R. Molecular adsorbent recycling system (MARS): clinical results of a new membrane-based blood purification system for bioartificial liver support. Artif Organs 23, 319, 1999.
29. Sugimoto, S., Mitaka, T., Ikeda, S., Harada, K., Ikai, I., Yamaoka, Y., and Mochizuki, Y. Morphological changes induced by extracellular matrix are correlated with maturation of rat small hepatocytes. J Cell Biochem 87, 16, 2002.
30. Mullon, C, and Pitkin, Z. The HepatAssist bioartificial liver support system: clinical study and pig hepatocyte process. Expert Opin Investig Drugs 8, 229, 1999.
31. Detry, O., Arkadopoulos, N., Ting, P., Kahaku, E., Wata-nabe, F.D., Rozga, J., and Demetriou, A.A. Clinical use of a bioartificial liver in the treatment of acetaminophen-induced fulminant hepatic failure. Am Surg 65, 934, 1999.
32. Yeh, S.Y. Urinary excretion of morphine and its metabolites in morphine-dependent subjects. J Pharmacol Exp Ther 192, 201, 1975.
33. Boerner, U., Roe, R.L., and Becker, C.E. Detection, isolation and characterization of normorphine and norcodeine as morphine metabolites in man. J Pharm Pharmacol 26, 393, 1974.
34. Court, M.H., Hao, Q., Krishnaswamy, S., Bekaii-Saab, T., Al-Rohaimi, A., von Moltke, L.L., and Greenblatt, D.J. UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver. J Pharmacol Exp Ther 310, 656, 2004.
35. Ferrari, A., Coccia, C.P., Bertolini, A., and Sternieri, E. Methadone\metabolism, pharmacokinetics and interactions. Pharmacol Res 50, 551, 2004.