Methadone, commonly used as maintenance medication for outpatient treatment of opioid dependence, kills leukemia cells and overcomes chemoresistance

Cancer Research

Volumn 68, Issue 15, 2008, Pages 6059-6064

  Friesen, Claudia ^a   Roscher, Mareike ^a   Alt, Andreas ^a   Miltner, Erich ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; METHADONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL XL; X LINKED INHIBITOR OF APOPTOSIS; DOXORUBICIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL DEATH; CELL KILLING; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; CELL STRAIN HL 60; DRUG EFFECT; DRUG RESISTANCE; LYMPHATIC LEUKEMIA; MYELOID LEUKEMIA; OPIATE ADDICTION; PATHOLOGY; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; HL-60 CELLS; HUMANS; LEUKEMIA, LYMPHOID; LEUKEMIA, MYELOID; METHADONE; OPIOID-RELATED DISORDERS;

EID: 51049083387     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-1227     Document Type: Article

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