Association between the interleukin-6 gene -572G/C and -597G/A polymorphisms and coronary heart disease in the Han Chinese

Medical Science Monitor

Volumn 16, Issue 3, 2010, Pages

  Jia, Xingwang ^a   Tian, Yaping ^a   Wang, Ying ^a   Deng, Xinxin ^a   Dong, Zhennan ^a   Scafa, Nikki ^b   Zhang, Xueji ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b Worcester Polytechnic Institute   (United States)

Author keywords

Genetic polymorphism; Interleukin 6; Real time PCR

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; ALLELE; ARTICLE; CHINESE; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; ETHNICITY; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOTE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

ADULT; AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CORONARY DISEASE; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; NUCLEIC ACID DENATURATION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77649251844     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Ross R: Atherosclerosis - an inflammatory disease. New Engl J Med, 1999; 340: 115-26
2. Blake GJ, Ridker PM: Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med, 2002; 252: 283-94
3. Libby P, Ridker PM: Inflammation and atherosclerosis: role of C-reactive protein in risk assessment. Am J Med, 2004; 111: 9S-16S
4. Mestries C, Kruithof EKO, Gascon MP et al: In vivo modulation of coagulation and fibrinolysis by recombinant glycosylated human interleukin-6 in baboons. Eur Cytokine Netw, 1994; 5: 273-281
5. Bataille R, Klein B: C-reactive protein levels as a direct indicator of interleukin-6 levels in humans in vivo. Arthritis Rheum, 1992; 35: 982-83
6. Blake GJ, Ridker PM: C-reactive protein and other inflammatory risk markers in acute coronary syndromes. J Am Coll Cardiol, 2003; 41: 37S-42S
7. Willerson JT, Ridker PM: Inflammation as a cardiovascular risk factor. Circulation, 2004; 109: 2-10
8. Biasucci LM, Liuzzo G, Fantuzzi G et al: Increasing concentrations of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events. Circulation, 1999; 99: 2079-84
9. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH: Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000; 101: 1767-72
10. Cesari M, Penninx BW, Newman AB et al: Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation, 2003; 108: 2317-22
11. Terry CF, Loukaci V, Green FR: Cooperative influence of genetic polymorphisms on interleukin-6 transcriptional regulation. J Biol Chem, 2000; 275(24): 18138-44
12. Humphies SE, Luong LA, Ogg MS et al: The interleukin-6 -174G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in health men. Eur Heart J, 2001; 22: 2243-52
13. Jones KG, Brull DJ, Brown LC et al: Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation, 2001; 103: 2260-65
14. Brull DJ, Montgomery HE, Sanders J et al: Interleukin-6 gene -174G>C and -572G>C promoter polymorphism are strong predictors of plasma interleukine-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol, 2001, 21: 1458-63
15. Chun SL, Shouhuan Z, Yon SK et al: The -174 G to C polymorphism of interleukin-6 gene is very rare in Koreans. Cytokine, 2002, 19(1): 52-54
16. Jia XW, Tian YP, Wang Y et al: Correlation of Polymorphism in IL6 Gene Promoter with BMI, Inflammatory Factors, and Pathogenesis and Progression of CHD, Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2007; 15(6): 1270-75
17. Fishman D, Faulds G, Jeffery R et al: The effect of novel in polymorphism in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 level and an association with systemic-onset juvenile chronic arthritis. J Clin Invest, 1998; 102: 1369-76
18. Bennermo M, Held C et al: Prognostic value of plasma interleukin-6 concentrations and the -174G>C and -572G>C promoter polymorphisms of the interleukin-6 gene in patients with acute myocardial infarction treated with thrombolysis. J Atherosclerosis; 2004; 157-63
19. Chung HW, Seo JS, Hur SE et al: Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. J Hum Genet, 2003; 48(5): 243-48
20. Saijo Y, Yoshioka E, Fukui T: Effects of the Interaction between Interleukin-6 634C/G Polymorphism and Smoking on Serum C-Reactive Protein Concentrations. Hypertens Res, 2007; 30(7): 593-99
21. De Michele A, Martin AM, Mick R et al: Interleukin-6 -174G-C polymorphism is associated with improved outcome in high-risk breast cancer. Cancer Res, 2003; 63: 8051-56
22. Wu DM, Chu NF, Shen MH, Wang SC: Obesity, plasma high sensitivity c-reactive protein levels and insulin resistance status among school children in Taiwan. Clin Biochem, 2006; 39: 810-15
23. Cummings DM, King DE, Mainous AG, Geesey ME: Combining serum biomarkers: the association of C-reactive protein, insulin sensitivity, and homocysteine with cardiovascular disease history in the general US population. Eur J Cardiovasc Prev Rehabil, 2006; 13(2): 180-85