Altered levels of acetylcholinesterase in Alzheimer plasma

PLoS ONE

Volumn 5, Issue 1, 2010, Pages

  García Ayllón, María Salud ^a,b   Riba Llena, Iolanda ^a,b,c   Serra Basante, Carol ^a,b   Alom, Jordi ^b,c   Boopathy, Rathnam ^d   Sáez Valero, Javier ^a,b  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO DE ELCHE   (Spain)

^d BHARATHIAR UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; TETRAMER;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ERYTHROCYTE; FEMALE; HUMAN; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; LECTIN BINDING; LIVER; MALE; SEDIMENTATION; WESTERN BLOTTING; BLOOD; CASE CONTROL STUDY;

ACETYLCHOLINESTERASE; AGED; ALZHEIMER DISEASE; BLOTTING, WESTERN; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE;

EID: 77649222337     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008701     Document Type: Article

References (64)

1. Davies P, Maloney AJF (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2: 1403.
2. Perry EK, Perry RH, Blessed G, Tomlinson BE (1977) Necropsy evidence of central cholinergic deficits in senile dementia. Lancet 1: 189.
3. Mesulam MM, Morán MA (1987) Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease. Ann Neurol 22: 223-228.
4. Ulrich J, Meier-Ruge W, Probst A, Meier E, Ipsen S (1990) Senile plaques: staining for acetylcholinesterase and A4 protein: a comparative study in the hippocampus and entorhinal cortex. Acta Neuropathol 80(6): 624-628.
5. Inestrosa NC, Alvarez A, Perez CA, Moreno RD, Vicente M, et al. (1996) Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron 16: 881-891.
6. Rees T, Hammond PI, Soreq H, Younkin S, Brimijoin S (2003) Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex. Neurobiol Aging 24: 777-787.
7. Massoulié J (2002) The origin of the molecular diversity and functional anchoring of cholinesterases. Neurosignals 11(3): 130-143.
8. Atack JR, Perry EK, Bonham JR, Perry RH, Tomlinson BE, et al. (1983) Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: selective loss of the intermediate (10S) form. Neurosci Lett 40(2): 199-204.
9. Sáez-Valero J, Sberna G, McLean CA, Small DH (1999) Molecular isoform distribution and glycosylation of acetylcholinesterase are altered in brain and cerebrospinal fluid of patients with Alzheimer's disease. J Neurochem 72: 1600-1608.
10. Arendt T, Brückner MK, Lange M, Bigl V (1992) Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development-a study of molecular forms. Neurochem Int 21(3): 381-396.
11. Appleyard ME, Smith AD, Wilcock GK, Esiri MM (1983) Decreased CSF acetylcholinesterase activity in Alzheimer's disease. Lancet 2(8347): 452.
12. Marquis JK, Volicer L, Mark KA, Direnfeld LK, Freedman M (1985) Cholinesterase activity in plasma, erythrocytes, and cerebrospinal fluid of patients with dementia of the Alzheimer type. Biol Psychiatry 20(6): 605-610.
13. Atack JR, May C, Kaye JA, Kay AD, Rapoport SI (1988) Cerebrospinal fluid cholinesterases in aging and in dementia of the Alzheimer type. Ann Neurol 23(2): 161-167.
14. Sáez-Valero J, Mok SS, Small DH (2000) An unusually glycosylated form of acetylcholinesterase is a CSF biomarker for Alzheimer's disease. Acta Neurol Scand Suppl 176: 49-2006.
15. Perry RH, Wilson ID, Bober MJ, Atack J, Blessed G, et al. (1982) Plasma and erythrocyte acetylcholinesterase in senile dementia of Alzheimer type. Lancet 1(8264): 174-175.
16. Atack JR, Perry EK, Perry RH, Wilson ID, Bober MJ, et al. (1985) Blood acetyland butyrylcholinesterases in senile dementia of Alzheimer type. J Neurol Sci 70(1): 1-12.
17. Sirviö J, Kutvonen R, Soininen H, Hartikainen P, Riekkinen PJ (1989) Cholinesterases in the cerebrospinal fluid, plasma, and erythrocytes of patients with Alzheimer's disease. J Neural Transm 75(2): 119-127.
18. Darreh-Shori T, Almkvist O, Guan ZZ, Garlind A, Strandberg B, et al. (2002) Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months. Neurology 59(4): 563-572.
19. Yamamoto Y, Nakano S, Kawashima S, Nakamura S, Urakami K, et al. (1990) Plasma and serum G4 isoenzyme of acetylcholinesterase in patients with Alzheimer-type dementia and vascular dementia. Ann Clin Biochem 27: 321-326.
20. Li B, Sedlacek M, Manoharan I, Boopathy R, Duysen EG, et al. (2005) Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Biochem Pharmacol 70(11): 1673-1684.
21. St Clair DM, Brock DJ, Barron L (1986) A monoclonal antibody assay technique for plasma and red cell acetylcholinesterase activity in Alzheimer's disease. Neurol Sci 73(2): 169-176.
22. Sorensen K, Brodbeck U, Rasmussen AG, Norgaard-Pedersen B (1986) Normal human serum contains two forms of acetylcholinesterase. Clin Chim Acta 158(1): 1-6.
23. Brimijoin S, Hammond P (1988) Butyrylcholinesterase in human brain and acetylcholinesterase in human plasma: trace enzymes measured by two-site immunoassay. J Neurochem 51(4): 1227-1231.
24. Mäder M, Soerensen K, Wiedmann T, Dickmann U, Felgenhauer K (1991) Neuronal acetylcholinesterase levels in cerebrospinal fluid and serum determined by a specific and sensitive immunoassay. Eur J Clin Chem Clin Biochem 29(1): 51-55.
25. Mintz KP, Brimijoin S (1985) Monoclonal antibodies to rabbit brain acetylcholinesterase: selective enzyme inhibition, differential affinity for enzyme forms, and cross-reactivity with other mammalian cholinesterases. J Neurochem 45(1): 284-292.
26. Rakonczay Z, Brimijoin S (1985) Immunochemical differences among molecular forms of acetylcholinesterase in brain and blood. Biochim Biophys Acta 832(2): 127-134.
27. Liao J, Boschetti N, Mortensen V, Jensen SP, Koch C, et al. (1994) Characterization of salt-soluble forms of acetylcholinesterase from bovine brain. J Neurochem 63(4): 1446-1453.
28. Boschetti N, Brodbeck U, Jensen SP, Koch C, Nørgaard-Pedersen B (1996) Monoclonal antibodies against a C-terminal peptide of human brain acetylcholinesterase distinguish between erythrocyte and brain acetylcholinesterases. Clin Chem 42(1): 19-23.
29. Flores-Flores C, Martínez-Martínez A, Campoy FJ, Brodbeck U, Vidal CJ (1997) Differential interaction of the monoclonal antibody AE-1 with acetylcholinesterase oligomers and monomers from rabbit muscle microsomes, human brain and fetal bovine serum. Neurosci Lett 239(2-3): 101-104.
30. García-Ayllón MS, Silveyra MX, Andreasen N, Brimijoin S, Blennow K, et al. (2007) Cerebrospinal fluid acetylcholinesterase changes after treatment with donepezil in patients with Alzheimer's disease. J Neurochem 101(6): 1701-1711.
31. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944.
32. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state" A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198.
33. Manoharan I, Wieseler S, Layer PG, Lockridge O, Boopathy R (2006) Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India. Pharmacogenet Genomics 16(7): 461-468.
34. Manoharan I, Kuznetsova A, Fisk JD, Boopathy R, Lockridge O, et al. (2007) Comparison of cognitive functions between people with silent and wild-type butyrylcholinesterase. J Neural Transm 114(7): 939-945.
35. Manoharan I, Boopathy R, Darvesh S, Lockridge O (2007) A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India. Clin. Chim Acta 378(1-2): 128-135.
36. Bourne Y, Taylor P, Radić Z, Marchot P (2003) Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site. EMBO J 22(1): 1-12.
37. Sternfeld M, Shoham S, Klein O, Flores-Flores C, Evron T, et al. (2000) Excess "read-through" acetylcholinesterase attenuates but the "synaptic" variant intensifies neurodeterioration correlates. Proc Natl Acad Sci U S A 97: 8647-8652.
38. Sáez-Valero J, de Gracia JA, Lockridge O (2005) Intraperitoneal administration of 340 kDa human plasma butyrylcholinesterase increases the level of the enzyme in the cerebrospinal fluid of rats. Neurosci Lett 383(1-2): 93-98.
39. Stieger S, Brodbeck U, Witzemann V (1987) Inactive monomeric acetylcholinesterase in the low-salt-soluble extract of the electric organ from Torpedo marmorata. J Neurochem 49(2): 460-467.
40. Rotundo RL (1988) Biogenesis of acetylcholinesterase molecular forms in muscle Evidence for a rapidly turning over, catalytically inactive precursor pool. J Biol Chem 263(36): 19398-19406.
41. Chatel JM, Grassi J, Frobert Y, Massoulié J, Vallette FM (1993) Existence of an inactive pool of acetylcholinesterase in chicken brain. Proc Natl Acad Sci U S A 90(6): 2476-2480.
42. La Du BN, Bartels CF, Nogueira CP, Arpagaus M, Lockridge O (1999) Proposed nomenclature for human butyrylcholinesterase genetic variants identified by DNA sequencing. Cell Mol Neurobiol 11(1): 79-89.
43. Méflah K, Bernard S, Massoulié J (1984) Interactions with lectins indicate differences in the carbohydrate composition of the membrane-bound enzymes acetylcholinesterase and 59-nucleotidase in different cell types. Biochimie 66: 59-69.
44. García-Ayllón MS, Silveyra MX, Candela A, CompañA, Clària J, et al. (2006) Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation. Hepatology 43: 444-453.
45. Grisaru D, Sternfeld M, Eldor A, Glick D, Soreq H (1999) Structural roles of acetylcholinesterase variants in biology and pathology. Eur J Biochem 264: 672-686.
46. Li B, Stribley JA, Ticu A, Xie W, Schopfer LM, et al. (2000) Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. J Neurochem 75(3): 1320-1331.
47. Atack JR, Perry EK, Bonham JR, Perry RH (1987) Molecular forms of acetylcholinesterase and butyrylcholinesterase in human plasma and cerebrospinal fluid. J Neurochem 48(6): 1845-1850.
48. Szilágyi AK, Németh A, Martini E, Lendvai B, Venter V (1987) Serum and CSF cholinesterase activity in various kinds of dementia. Eur Arch Psychiatry Neurol Sci 236(5): 309-311.
49. Jaganathan L, Boopathy R (1998) Interaction of Triton X-100 with acyl pocket of butyrylcholinesterase: effect on esterase activity and inhibitor sensitivity of the enzyme. Indian J Biochem Biophys 35: 142-147.
50. Sberna G, Sáez-Valero J, Li QX, Czech C, Beyreuther K, et al. (1998) Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the beta-amyloid protein precursor of Alzheimer's disease. J Neurochem 71: 723-731.
51. Sáez-Valero J, de Ceballos ML, Small DH, de Felipe C (2002) Changes in molecular isoform distribution of acetylcholinesterase in rat cortex and cerebrospinal fluid after intracerebroventricular administration of amyloid beta-peptide. Neurosci Lett 325(3): 199-202.
52. Tsim KW, Randall WR, Barnard EA (1988) Synaptic acetylcholinesterase of chicken muscle changes during development from a hybrid to a homogeneous enzyme. EMBO J 7(8): 2451-2456.
53. García-Ayllón MS, Sáez-Valero J, Muñoz-Delgado E, Vidal CJ (2001) Identification of hybrid cholinesterase forms consisting of acetyl- and butyrylcholinesterase subunits in human glioma. Neuroscience 107(2): 199-208.
54. Hodgson AJ, Chubb IW (1983) Isolation of the secretory form of soluble acetylcholinesterase by using affinity chromatography on edrophonium-Sepharose. J Neurochem 41(3): 654-662.
55. García-Ayllón MS, Gómez JL, Vidal CJ (1999) Amphiphilic properties of acetylcholinesterase monomers in mouse plasma. Neurosci Lett 265(3): 211-214.
56. Darreh-Shori T, Hellström-Lindahl E, Flores-Flores C, Guan ZZ, Soreq H, et al. (2004) Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients. J Neurochem 88(5): 1102-1113.
57. Carvalho FA, Graça LM, Martins-Silva J, Saldanha C (2005) Biochemical characterization of human umbilical vein endothelial cell membrane bound acetylcholinesterase. FEBS J 272(21): 5584-5594.
58. Santos SC, Vala I, Miguel C, Barata JT, Garção P, et al. (2007) Expression and subcellular localization of a novel nuclear acetylcholinesterase protein. J Biol Chem 282(35): 25597-25603.
59. García-Ayllón MS, Cauli O, Silveyra MX, Rodrigo R, Candela A, et al. (2008) Brain cholinergic impairment in liver failure. Brain 131(Pt 11): 2946-2956.
60. Silveyra MX, Evin G, Montenegro MF, Vidal CJ, Martínez S, et al. (2008) Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosilation. Mol Cell Biol 28(9): 2908-2919.
61. Meshorer E, Toiber D, Zurel D, Sahly I, Dori A, et al. (2004) Combinatorial complexity of 59 alternative acetylcholinesterase transcripts and protein products. J Biol Chem 279: 29740-29751.
62. Toiber D, Berson A, Greenberg D, Melamed-Book N, Diamant S, Soreq H (2008) N-acetylcholinesterase-induced apoptosis in Alzheimer's disease. PLoS ONE 3: e3108.
63. Kalaria RN (1999) The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease. Ann N Y Acad Sci 893: 113-125.
64. Mooradian AD (1988) Effect of aging on the blood-brain barrier. Neurobiol Aging 9(1): 31-39.