Polymorphisms and haplotypes in the interleukin-4 gene are associated with chronic periodontitis in a Brazilian population

Journal of Periodontology

Volumn 81, Issue 3, 2010, Pages 392-402

  Anovazzi, Giovana ^a   Kim, Yeon J ^a   Viana, Aline C ^a   Curtis, Karen M C ^a   Orrico, Silvana R P ^a   Cirelli, Joni A ^a   Scarel Caminaga, Raquel M ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Disease susceptibility; Genetics; Periodontitis

Indexed keywords

INTERLEUKIN 4;

ADULT; AGE; ARTICLE; BRAZIL; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; CHRONIC PERIODONTITIS; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HAPLOTYPE; HUMAN; MALE; MONTE CARLO METHOD; OBSERVER VARIATION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; STATISTICAL MODEL; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; AGE FACTORS; BRAZIL; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHRONIC PERIODONTITIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INTERLEUKIN-4; LIKELIHOOD FUNCTIONS; LINKAGE DISEQUILIBRIUM; LOGISTIC MODELS; MALE; MINISATELLITE REPEATS; MONTE CARLO METHOD; MUTAGENESIS, INSERTIONAL; OBSERVER VARIATION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS; SMOKING;

EID: 77649199510     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2009.090392     Document Type: Article

References (50)

1. Kinane DF, Hart TC. Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med 2003;14:430-449.
2. Loos BG, John RP, Laine ML. Identification of genetic risk factors for periodontitis and possible mechanisms of action. J Clin Periodontol 2005;32(Suppl. 6):159-179.
3. Shapira L, Van Dyke TE, Hart TC. A localized absence of interleukin-4 triggers periodontal disease activity: A novel hypothesis. Med Hypotheses 1992;39:319-322.
4. Tew J, Engel D, Mangan D. Polyclonal B-cell activation in periodontitis. J Periodontal Res 1989;24:225-241.
5. Mosmann TR, Coffman RL. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
6. Vandenbroeck K, Goris A. Cytokine gene polymorphisms in multifactorial diseases: Gateways to novel targets for immunotherapy? Trends Pharmacol Sci 2003;24:284-289.
7. Gemmell E, Seymour GJ. Modulation of immune responses to periodontal bacteria. Curr Opin Periodontol 1994;28-38.
8. Arai N, Nomura D, Villaret D, et al. Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression. J Immunol 1989;142:274-282.
9. Le Beau MM, Lemons RS, Espinosa R, 3rd, Larson RA, Arai N, Rowley JD. Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q). Blood 1989; 73:647-650.
10. Shibata N, Ohnuma T, Takahashi T, et al. The effect of IL4 +33C/T polymorphism on risk of Japanese sporadic Alzheimer9s disease. Neurosci Lett 2002;323: 161-163.
11. Van der Pouw Kraan TC, Kucukaycan M, Bakker AM, et al. Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism. Genes Immun 2002;3:436-439. (Pubitemid 41656545) (Pubitemid 41656545)
12. Kantarci OH, Schaefer-Klein JL, Hebrink DD, et al. A population-based study of IL4 polymorphisms in multiple sclerosis. J Neuroimmunol 2003;137:134-139.
13. Basehore MJ, Howard TD, Lange LA, et al. A comprehensive evaluation of IL4 variants in ethnically diverse populations: Association of total serum IgE levels and asthma in white subjects. J Allergy Clin Immunol 2004;114:80-87.
14. Holla LI, Fassmann A, Augustin P, Halabala T, Znojil V, Vanek J. The association of interleukin-4 haplotypes with chronic periodontitis in a Czech population. J Periodontol 2008;79:1927-1933.
15. Takabayashi A, Ihara K, Sasaki Y, Kusuhara K, Nishima S, Hara T. Novel polymorphism in the 59- untranslated region of the interleukin-4 gene. J Hum Genet 1999;44:352-353.
16. Gonzales JR, Mann M, Stelzig J, Bodeker RH, Meyle J. Single-nucleotide polymorphisms in the IL-4 and IL-13 promoter region in aggressive periodontitis. J Clin Periodontol 2007;34:473-479.
17. Mout R, Willemze R, Landegent JE. Repeat polymorphisms in the interleukin-4 gene (IL4). Nucleic Acids Res 1991;19:3763.
18. Vandenbroeck K, Martino G, Marrosu M, et al. Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis. J Neuroimmunol 1997;76:189-192. (Pubitemid 27272646) (Pubitemid 27272646)
19. Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB Jr., Line SR. Investigation of IL4 gene polymorphism in individuals with different levels of chronic periodontitis in a Brazilian population. J Clin Periodontol 2003;30:341-345.
20. Pontes CC, Gonzales JR, Novaes AB Jr., et al. 'Interleukin- 4 gene polymorphism and its relation to periodontal disease in a Brazilian population of African heritage'. J Dent 2004;32:241-246.
21. Michel J, Gonzales JR, Wunderlich D, Diete A, Herrmann JM, Meyle J. Interleukin-4 polymorphisms in early onset periodontitis. J Clin Periodontol 2001; 28:483-488.
22. Kim YJ, Viana AC, Curtis KM, Orrico SR, Cirelli JA, Scarel-Caminaga RM. Lack of association of a functional polymorphism in the interleukin 8 gene with susceptibility to periodontitis. DNA Cell Biol 2009; 28:185-190.
23. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-7.
24. Kornman KS, Crane A, Wang HY, et al. The interleukin- 1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997;24:72-77.
25. Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: Design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003;19:149-150.
26. Brett PM, Zygogianni P, Griffiths GS, et al. Functional gene polymorphisms in aggressive and chronic periodontitis. J Dent Res 2005;84:1149-1153.
27. Dini EL, Castellanos RA. CPITN: Time and cost estimates for periodontal prevention and treatment procedures. Braz Dent J 1995;6:53-58.
28. Schneider SR, Excoffier D, Arlequin L. A Software for Population Genetics Data Analysis. Geneva: University of Geneva; 2000:114.
29. Lewontin RC. The interaction of selection and linkage I. General considerations; heterotic models. Genetics 1964;49:49-67.
30. Sham PC, Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 1995;59:97-105.
31. Rosenwasser LJ, Klemm DJ, Dresback JK, et al. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995;25(Suppl. 2):74-78; discussion 95-96.
32. Noguchi E, Shibasaki M, Arinami T, et al. Association of asthma and the interleukin-4 promoter gene in Japanese. Clin Exp Allergy 1998;28:449-453. (Pubitemid 28215767) (Pubitemid 28215767)
33. Gonzales JR, Kobayashi T, Michel J, Mann M, Yoshie H, Meyle J. Interleukin-4 gene polymorphisms in Japanese and Caucasian patients with aggressive periodontitis. J Clin Periodontol 2004;31:384-389. (Pubitemid 38624031) (Pubitemid 38624031)
34. Hooshmand B, Monsef A, Amirmadglesi M, Kashani M. Oral fluid antibody detection in the diagnosis of gastric Helicobacter pylori infection. Iran J Allergy Asthma Immunol 2004;3:127-131.
35. Baynam G, Zhang G, Khoo SK, et al. Gender-specific effects of cytokine gene polymorphisms on childhood vaccine responses. Vaccine 2008;26:3574-3579.
36. Li Y, Botão G, Lin Z, Jiaxin H, Bo W, Hongyan X. Association between C-589T polymorphisms of interleukin- 4 gene promoter and asthma: A meta-analysis. Respir Med 2008;102:984-992.
37. Noguchi E, Nukaga-Nishio Y, Jian Z, et al. Haplotypes of the 59 region of the IL-4 gene and SNPs in the intergene sequence between the IL-4 and IL-13 genes are associated with atopic asthma. Hum Immunol 2001;62:1251-1257.
38. Nakashima H, Miyake K, Inoue Y, et al. Association between IL-4 genotype and IL-4 production in the Japanese population. Genes Immun 2002;3:107-109.
39. Alves-Silva J, da Silva Santos M, Guimaraes PE, et al. The ancestry of Brazilian mtDNA lineages. Am J Hum Genet 2000;67:444-461.
40. Parra FC, Amado RC, Lambertucci JR, Rocha J, Antunes CM, Pena SD. Color and genomic ancestry in Brazilians. Proc Natl Acad Sci USA 2003;100:177-182.
41. Pimenta JR, Zuccherato LW, Debes AA, et al. Color and genomic ancestry in Brazilians: A study with forensic microsatellites. Hum Hered 2006;62:190-195.
42. Quirico-Santos T, Suppiah V, Heggarty S, Caetano R, Alves-Leon S, Vandenbroeck K. Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis. Arq Neuropsiquiatr 2007;65:15-19.
43. Mittal RD, Manchanda PK. Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease. Immunogenetics 2007;59:159-165.
44. Suzuki I, Hizawa N, Yamaguchi E, Kawakami Y. Association between a C+33T polymorphism in the IL-4 promoter region and total serum IgE levels. Clin Exp Allergy 2000;30:1746-1749. (Pubitemid 32011754) (Pubitemid 32011754)
45. Fujihashi K, Beagley KW, Kono Y, et al. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol 1993;142:1239-1250.
46. Bozkurt FY, Yetkin Ay Z, Berker E, Tepe E, Akkus S. Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and rheumatoid arthritis: A preliminary report. Cytokine 2006;35: 180-185.
47. Kabashima H, Nagata K, Hashiguchi I, et al. Interleukin- 1 receptor antagonist and interleukin-4 in gingival crevicular fluid of patients with inflammatory periodontal disease. J Oral Pathol Med 1996;25:449-455.
48. Salvi GE, Brown CE, Fujihashi K, et al. Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. J Periodontal Res 1998;33:212-225.
49. Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono H. Molecular and cellular mechanisms for periodontal diseases: Role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodontal Res 1997;32:115-119.
50. Kamma JJ, Giannopoulou C, Vasdekis VG, Mombelli A. Cytokine profile in gingival crevicular fluid of aggressive periodontitis: Influence of smoking and stress. J Clin Periodontol 2004;31:894-902.