Does daily vitamin D 800 IU and calcium 1000 mg supplementation decrease the risk of falling in ambulatory women aged 65-71 years? A 3-year randomized population-based trial (OSTPRE-FPS)

Maturitas

Volumn 65, Issue 4, 2010, Pages 359-365

  Kärkkäinen, Matti K ^a   Tuppurainen, Marjo ^a,b   Salovaara, Kari ^a,b   Sandini, Lorenzo ^b   Rikkonen, Toni ^a   Sirola, Joonas ^a,b   Honkanen, Risto ^a   Arokoski, Jari ^b   Alhava, Esko ^a   Kröger, Heikki ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Calcium; Falls; Population based study; Randomized controlled trial; Vitamin D

Indexed keywords

CALCICHEW D3 FORTE; CALCIUM CARBONATE; COLECALCIFEROL; UNCLASSIFIED DRUG;

AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; FALLING; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; PATIENT COMPLIANCE; POPULATION RESEARCH; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK REDUCTION;

ACCIDENTAL FALLS; AGED; CALCIUM; FEMALE; HUMANS; PATIENT COMPLIANCE; VITAMIN D; VITAMINS;

EID: 77649189958     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2009.12.018     Document Type: Article

References (31)

1. Campbell A.J., Reinken J., Allan B.C., and Martinez G.S. Falls in old age: a study of frequency and related clinical factors. Age Ageing 10 November (4) (1981) 264-270
2. Sattin R.W., Lambert Huber D.A., DeVito C.A., et al. The incidence of fall injury events among the elderly in a defined population. Am J Epidemiol 131 June (6) (1990) 1028-1037
3. Nevitt M.C., Cummings S.R., and Hudes E.S. Risk factors for injurious falls: a prospective study. J Gerontol 46 September (5) (1991) M164-M170
4. Tinetti M.E., Doucette J., Claus E., and Marottoli R. Risk factors for serious injury during falls by older persons in the community. J Am Geriatr Soc 43 November (11) (1995) 1214-1221
5. Bischoff-Ferrari H.A. The 25-hydroxyvitamin D threshold for better health. J Steroid Biochem Mol Biol 103 March (3-5) (2007) 614-619
6. Margiloff L., Harris S.S., Lee S., Lechan R., and Dawson-Hughes B. Vitamin D status of an outpatient clinic population. Calcif Tissue Int 69 5 (2001) 263-267
7. Lamberg-Allardt C.J., Outila T.A., Karkkainen M.U., Rita H.J., and Valsta L.M. Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe?. J Bone Miner Res 16 11 (2001) 2066-2073
8. Gloth III F.M., Gundberg C.M., Hollis B.W., Haddad Jr. J.G., and Tobin J.D. Vitamin D deficiency in homebound elderly persons. JAMA 274 December (21) (1995) 1683-1686
9. Pfeifer M., Begerow B., and Minne H.W. Vitamin D and muscle function. Osteoporos Int 13 March (3) (2002) 187-194
10. Venning G. Recent developments in vitamin D deficiency and muscle weakness among elderly people. BMJ 330 March (7490) (2005) 524-526
11. Bischoff H.A., Stähelin H.B., Dick W., et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18 February (2) (2003) 343-351
12. Bischoff-Ferrari H.A., Borchers M., Gudat F., Dürmüller U., Stähelin H.B., and Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 19 February (2) (2004) 265-269
13. Glerup H., Mikkelsen K., Poulsen L., et al. Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif Tissue Int 66 June (6) (2000) 419-424
14. Pfeifer M., Begerow B., Minne H.W., Abrams C., Nachtigall D., and Hansen C. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 15 June (6) (2000) 1113-1118
15. Jackson R.D., LaCroix A.Z., Gass M., et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354 February (7) (2006) 669-683
16. Chapuy M.C., Arlot M.E., Duboeuf F., et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 327 December (23) (1992) 1637-1642
17. Bischoff-Ferrari H.A., Dawson-Hughes B., Willett W.C., et al. Effect of Vitamin D on falls: a meta-analysis. JAMA 291 April (16) (2004) 1999-2006
18. Bischoff-Ferrari H.A., Willett W.C., Wong J.B., Giovannucci E., Dietrich T., and Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293 May (18) (2005) 2257-2264
19. Honkanen R., Alhava E.M., Saarikoski S., and Tuppurainen M. Osteoporosis risk factors in perimenopausal women. Calcif Tissue Int 49 Suppl. (1991) S74-S75
20. Graafmans W.C., Ooms M.E., Hofstee H.M., Bezemer P.D., Bouter L.M., and Lips P. Falls in the elderly: a prospective study of risk factors and risk profiles. Am J Epidemiol 143 June (11) (1996) 1129-1136
21. Larsen E.R., Mosekilde L., and Foldspang A. Vitamin D and calcium supplementation prevents severe falls in elderly community-dwelling women: a pragmatic population-based 3-year intervention study. Aging Clin Exp Res 17 April (2) (2005) 125-132
22. Bischoff-Ferrari H.A., Dietrich T., Orav E.J., et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr 80 September (3) (2004) 752-758
23. Bischoff-Ferrari H.A., and Dawson-Hughes B. Where do we stand on vitamin D?. Bone 41 Suppl. 1 July (1) (2007) S13-S19
24. Bischoff-Ferrari H.A., Dawson-Hughes B., Staehelin H.B., et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 339 October (b3692) (2009) 10.1136/bmj.b3692
25. Salovaara K., Tuppurainen M., Rikkonen T., et al. Effect of vitamin D3 and calcium on fracture risk in 65-71 year old women in a 3-year randomized clinical trial-preliminary results of the OSTPRE-Fracture Prevention Study. Abstract. ASBMR 29th Annual Meeting. Honolulu, Hawaii, USA, 16-19 September (2007)
26. Steingrimsdottir L., Gunnarsson O., Indridason O.S., Franzson L., and Sigurdsson G. Relationship between serum parathyroid hormone levels. Vitamin D sufficiency, and calcium intake. JAMA 294 (2005) 2336-2341
27. Dukas L., Bischoff H.A., Lindpaintner L.S., et al. Alfacalcidol reduces the number of fallers in a community-dwelling elderly population with a minimum calcium intake of more than 500 mg daily. J Am Geriatr Soc 52 February (2) (2004) 230-236
28. Tang B.M., Eslick G.D., Nowson C., Smith C., and Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 370 August (9588) (2007) 657-666
29. Cummings S.R., Nevitt M.C., and Kidd S. Forgetting falls. The limited accuracy of recall of falls in the elderly. J Am Geriatr Soc 36 July (7) (1988) 613-616
30. Kanten D.N., Mulrow C.D., Gerety M.B., Lichtenstein M.J., Aquilar C., and Cornell J.E. Falls: an examination of three reporting methods in nursing homes. J Am Geriatr Soc 42 June (6) (1993) 662-666
31. Pasco J.A., Henry M.J., Kotowicz M.A., et al. Seasonal periodicity of serum vitamin D and parathyroid hormone, bone resorption, and fractures: The Geelong Osteoporosis Study. J Bone Miner Res 19 (2004) 752-758