Development and validation of a sensitive and selective UHPLC-MS/MS method for quantitation of an investigational anti-malarial compound, 2-tert-butylprimaquine (NP-96) in rat plasma, and its application in a preclinical pharmacokinetic study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 3, 2010, Pages 410-415

  Mayatra, Sujal J ^a   Prasad, Bhagwat ^a   Jain, Meenakshi ^a   Jain, Rahul ^a   Singh, Saranjit ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

2 tert Butylprimaquine; Anti malarial drugs; Bioanalytical method validation; Selective reaction monitoring (SRM); Ultra high performance liquid chromatography tandem mass spectrometry (UHPLC MS MS)

Indexed keywords

2 TERT BUTYLPRIMAQUINE; ACETONITRILE; AMMONIUM ACETATE; ANTIMALARIAL AGENT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

ANIMALS; ANTIMALARIALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; DRUGS, INVESTIGATIONAL; FREEZING; MALE; MOLECULAR STRUCTURE; PRIMAQUINE; QUALITY CONTROL; RANDOM ALLOCATION; RATS; RATS, WISTAR; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TEMPERATURE; TIME FACTORS;

EID: 77649181125     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.05.033     Document Type: Article

References (11)

1. World Health Report 2008 (2008), World Health Organization, Geneva, Switzerland
2. Warhurst D. Afr. Health 19 (1997) 21-23
3. Rogers D.J., and Randolph S.E. Science 289 (2000) 1763-1766
4. Vangapandu S., Jain M., Kaur K., Patil P., Patel S.R., and Jain R. Med. Res. Rev. 27 (2007) 65-107
5. Jain M., Vangapandu S., Sachdeva S., Singh S., Singh P.P., Jena G.B., Tikoo K., Ramarao P., Kaul C.L., and Jain R. J. Med. Chem. 47 (2004) 285-287
6. Vangapandu S., Sachdeva S., Jain M., Singh S., Singh P.P., Kaul C.L., and Jain R. Bioorg. Med. Chem. 11 (2003) 4557-4568
7. Vangapandu S., Sachdeva S., Jain M., Singh S., Singh P.P., Kaul C.L., and Jain R. Bioorg. Med. Chem. 12 (2004) 239-247
8. Huy N.T., Mizunuma K., Kaur K., Nhien N.T., Jain M., Uyen D.T., Harada S., Jain R., and Kamei K. Antimicrob. Agents. Chemother. 51 (2007) 2842-2847
9. Guidance for Industry: Bioanalytical Method Validation, U.S. Department of Health and Human Services, Food and Drug Administration, CDER, Rockville, MD, 2001.
10. Keller B.O., Sui J., Young A.B., and Whittal R.M. Anal. Chim. Acta 627 (2008) 71-81
11. Serajuddin A.T. Adv. Drug Deliv. Rev. 59 (2007) 603-616