Immunoglobulin-like cell adhesion molecules: Novel signaling players in epithelial ovarian cancer

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 5, 2010, Pages 590-594

  Bombardelli, Lorenzo ^a   Cavallaro, Ugo ^a  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

Epithelial ovarian cancer; Ig CAMs; L1; Receptor tyrosine kinases; Shedding

Indexed keywords

CELL SURFACE PROTEIN; IMMUNOGLOBULIN LIKE CELL ADHESION MOLECULE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

BIOLOGICAL ACTIVITY; CANCER GROWTH; CARCINOGENESIS; DRUG TARGETING; HUMAN; NONHUMAN; OVARY CANCER; PROTEIN DEGRADATION; PROTEIN FUNCTION; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALS; CARCINOMA; CELL ADHESION MOLECULES; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOGLOBULINS; OVARIAN NEOPLASMS; PEPTIDE FRAGMENTS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 77649179201     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.01.017     Document Type: Short Survey

References (30)

1. Aricescu A.R., and Jones E.Y. Immunoglobulin superfamily cell adhesion molecules: zippers and signals. Curr Opin Cell Biol 19 (2007) 543-550
2. Cavallaro U., and Christofori G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4 (2004) 118-132
3. Cavallaro U., Niedermeyer J., Fuxa M., and Christofori G. N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nat Cell Biol 3 (2001) 650-657
4. De Cecco L., Marchionni L., Gariboldi M., Reid J.F., Lagonigro M.S., Caramuta S., et al. Gene expression profiling of advanced ovarian cancer: characterization of a molecular signature involving fibroblast growth factor 2. Oncogene 23 (2004) 8171-8183
5. Dubeau L. The cell of origin of ovarian epithelial tumours. Lancet Oncol 9 (2008) 1191-1197
6. Friedli A., Fischer E., Novak-Hofer I., Cohrs S., Ballmer-Hofer K., Schubiger P.A., et al. The soluble form of the cancer-associated L1 cell adhesion molecule is a pro-angiogenic factor. Int J Biochem Cell Biol 41 (2009) 1572-1580
7. Gast D., Riedle S., Issa Y., Pfeifer M., Beckhove P., Sanderson M.P., et al. The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies. Oncogene 27 (2008) 1281-1289
8. Gast D., Riedle S., Schabath H., Schlich S., Schneider A., Issa Y., et al. L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas. Int J Cancer 115 (2005) 658-665
9. Gavert N., Conacci-Sorrell M., Gast D., Schneider A., Altevogt P., Brabletz T., et al. L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J Cell Biol 168 (2005) 633-642
10. Gutwein P., Stoeck A., Riedle S., Gast D., Runz S., Condon T.P., et al. Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells. Clin Cancer Res 11 (2005) 2492-2501
11. Islam R., Kristiansen L.V., Romani S., Garcia-Alonso L., and Hortsch M. Activation of EGF receptor kinase by L1-mediated homophilic cell interactions. Mol Biol Cell 15 (2004) 2003-2012
12. Loers G., and Schachner M. Recognition molecules and neural repair. J Neurochem 101 (2007) 865-882
13. Maddaluno L., Verbrugge S.E., Martinoli C., Matteoli G., Chiavelli A., Zeng Y., et al. The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells. J Exp Med 206 (2009) 623-635
14. Maetzel D., Denzel S., Mack B., Canis M., Went P., Benk M., et al. Nuclear signalling by tumour-associated antigen EpCAM. Nat Cell Biol 11 (2009) 162-171
15. Maness P.F., and Schachner M. Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration. Nat Neurosci 10 (2007) 19-26
16. Maretzky T., Schulte M., Ludwig A., Rose-John S., Blobel C., Hartmann D., et al. L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth. Mol Cell Biol 25 (2005) 9040-9053
17. Mezzanzanica D., Fabbi M., Bagnoli M., Staurengo S., Losa M., Balladore E., et al. Subcellular localization of activated leukocyte cell adhesion molecule is a molecular predictor of survival in ovarian carcinoma patients. Clin Cancer Res 14 (2008) 1726-1733
18. Munz M., Kieu C., Mack B., Schmitt B., Zeidler R., and Gires O. The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 23 (2004) 5748-5758
19. Nagaraj K., Kristiansen L.V., Skrzynski A., Castiella C., Garcia-Alonso L., and Hortsch M. Pathogenic human L1-CAM mutations reduce the adhesion-dependent activation of EGFR. Hum Mol Genet 18 (2009) 3822-3831
20. Novak-Hofer I., Cohrs S., Grunberg J., Friedli A., Schlatter M.C., Pfeifer M., et al. Antibodies directed against L1-CAM synergize with Genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells. Cancer Lett 261 (2008) 193-204
21. Osta W.A., Chen Y., Mikhitarian K., Mitas M., Salem M., Hannun Y.A., et al. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 64 (2004) 5818-5824
22. Primiano T., Baig M., Maliyekkel A., Chang B.D., Fellars S., Sadhu J., et al. Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements. Cancer Cell 4 (2003) 41-53
23. Riedle S., Kiefel H., Gast D., Bondong S., Wolterink S., Gutwein P., et al. Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity. Biochem J 420 (2009) 391-402
24. Rosso O., Piazza T., Bongarzone I., Rossello A., Mezzanzanica D., Canevari S., et al. The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells. Mol Cancer Res 5 (2007) 1246-1253
25. Sellar G.C., Watt K.P., Rabiasz G.J., Stronach E.A., Li L., Miller E.P., et al. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Nat Genet 34 (2003) 337-343
26. Spizzo G., Went P., Dirnhofer S., Obrist P., Moch H., Baeuerle P.A., et al. Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer. Gynecol Oncol 103 (2006) 483-488
27. Stoeck A., Gast D., Sanderson M.P., Issa Y., Gutwein P., and Altevogt P. L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Gynecol Oncol 104 (2007) 461-469
28. Trzpis M., McLaughlin P.M., de Leij L.M., and Harmsen M.C. Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule. Am J Pathol 171 (2007) 386-395
29. Yamashita T., Budhu A., Forgues M., and Wang X.W. Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res 67 (2007) 10831-10839
30. Zecchini S., Bianchi M., Colombo N., Fasani R., Goisis G., Casadio C., et al. The differential role of L1 in ovarian carcinoma and normal ovarian surface epithelium. Cancer Res 68 (2008) 1110-1118