Cellular calcium regulatory machinery of vasorelaxation elicited by petasin

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 3, 2010, Pages 309-315

  Wang, Guei Jane ^a   Lin, Yun Lian ^a   Chen, Chu Huang ^b   Wu, Xi Chen ^c   Liao, Jyh Fei ^a   Ren, Jun ^d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TEXAS HEART INSTITUTE   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

^d UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

Author keywords

Ca2+ regulation; Petasin; Vasoconstriction; Vasorelaxation

Indexed keywords

CALCIUM CHANNEL L TYPE; MW 316; PETASIN; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; ENDOTHELIUM; EXTRACELLULAR CALCIUM; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PETASITES; PETASITES FORMOSANUS; RAT; REGULATORY MECHANISM; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION;

ANIMALS; AORTA; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; MALE; MYOCYTES, SMOOTH MUSCLE; PETASITES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; VASODILATION;

EID: 77649176909     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05283.x     Document Type: Article

References (17)

1. Wang GJ, Shum AY, Lin YL et al. Calcium channel blockade in vascular smooth muscle cells. Major hypotensive mechanism of S-petasin, a hypotensive sesquiterpene from Petasites formosanus. J. Pharmacol. Exp. Ther. 2001 297 : 240 246.
2. 2+ channel blocking effect of iso-S-petasin in rat aortic smooth muscle cells. Eur. J. Pharmacol. 2002 445 : 239 245.
3. 2+ transients in adult rat ventricular myocytes. J. Pharm. Pharmacol. 2003 55 : 103 107. (Pubitemid 36142087)
4. Wang GJ, Liao JF, Hintz KK et al. Calcium-antagonizing activity of S-petasin, a hypotensive sesquiterpene from Petasites formosanus, on inotropic and chronotropic responses in isolated rat atria and cardiac myocytes. Naunyn Schmiedebergs Arch. Pharmacol. 2004 369 : 322 329.
5. Lin YL, Ou JC, Chen CF, Kuo YH. Eremophilanes from Petasites formosanus Kitamura. Chem. Pharm. Bull. 1998 46 : 1807 1809.
6. Wang GJ, Shan J, Pang PKP, Yang MC, Chou CJ, Chen CF. The vasorelaxing action of rutaecarpine: Direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells. J. Pharmacol. Exp. Ther. 1996 276 : 1016 1021.
7. 2+ channels. Nature 1983 303 : 535 537.
8. Wang GJ, Wu XC, Chen CF et al. The vasorelaxing action of rutaecarpine: Effects of rutaecarpine on calcium channel activities in vascular endothelial and smooth muscle cells. J. Pharmacol. Exp. Ther. 1999 289 : 1237 1244.
9. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985 260 : 3440 3450.
10. 1-adrenoceptors of portal hypertensive rats. Br. J. Pharmacol. 1994 111 : 439 444.
11. 50) of an enzymatic reaction. Biochem. Pharmacol. 1973 22 : 3099 3108.
12. Bollag DM, Edelstein SJ. Protein concentration determination. In : Protein Methods. Wiley-Liss, New York 1991 pp. 50 5.
13. Huguet F, Brisac AM, Roche A, Dubray C. Absence of a direct coupling of a G protein to dihydropyridine binding sites in rat heart. Biochem. Pharmacol. 1992 44 : 1680 1682.
14. Hermsmeyer K, Erne P. Cellular calcium regulation in hypertension. Am. J. Hypertens. 1989 2 : 655 658.
15. 2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats. Role of Ca2+ regulatory proteins. Cell Biochem. Biophys. 2005 42 : 1 12.
16. 2+ channels by petasins and eudesmol isomers. J. Pharmacol. Exp. Ther. 2009 330 : 220 226.
17. Sheykhzade M, Smajilovic S, Issa A, Haunso S, Christensen SB, Tfelt-Hansen J. S-Petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis. Eur. J. Pharmacol. 2008 593 : 79 86.