Calcium-antagonizing activity of S-petasin, a hypotensive sesquiterpene from Petasites formosanus, on inotropic and chronotropic responses in isolated rat atria and cardiac myocytes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 369, Issue 3, 2004, Pages 322-329

  Wang, Guei Jane ^b   Liao, Jyh Fei ^c   Hintz, Kadon K ^a   Chen, Wen Pin ^d   Su, Ming Jai ^d   Lin, Yun Lian ^b   Shi, Chuen Chao ^c   Chen, Chieh Fu ^b   Ren, Jun ^a  

^a UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Heart rate; ICa,L; Intracellular Ca2+ transient; Isolated atria; S petasin; Ventricular myocytes

Indexed keywords

ANTIHYPERTENSIVE AGENT; ATROPINE; CALCIUM CHANNEL L TYPE; CALCIUM ION; ISRADIPINE; MW 334; NIFEDIPINE; PETASIN; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CALCIUM MOBILIZATION; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG RECEPTOR BINDING; HEART ATRIUM MUSCLE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; INOTROPISM; MALE; NONHUMAN; PETASITES; PETASITES FORMOSANUS; RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART ATRIA; HEART RATE; HYPOTENSION; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PETASITES; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES;

EID: 1642307262     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0863-8     Document Type: Article

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