Genetics and molecular biology: Brain cholesterol balance - Not such a closed circuit after all

Current Opinion in Lipidology

Volumn 21, Issue 1, 2010, Pages 93-94

  Mutka, Aino Liisa ^a   Ikonen, Elina ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN RECEPTOR; LIPID; SCAVENGER RECEPTOR B; SQUALENE SYNTHASE; VASCULOTROPIN;

ANGIOGENESIS; ASTROCYTE; BIOSYNTHESIS; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; ENDOTHELIUM CELL; GLIA; HUMAN; MOLECULAR BIOLOGY; MYELINATION; NERVE CELL; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STEM CELL;

ANIMALS; BRAIN; CHOLESTEROL; GENETICS; MICE;

EID: 77649169140     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32833538b7     Document Type: Note

References (10)

1. Saher G, Brugger B, Lappe-Siefke C, et al. High cholesterol level is essential for myelin membrane growth. Nat Neurosci 2005; 8:468-475.
2. Mauch DH, NaglerK, SchumacherS, et al. CNSsynaptogenesis promoted by glia-derived cholesterol. Science 2001; 294:1354-1357.
3. Bjorkhem I, Meaney S. Brain cholesterol: long secret life behind a barrier. Arterioscler Thromb Vasc Biol 2004; 24:806-815.
4. Dietschy JM, Turley SD. Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res 2004; 45:1375-1397.
5. Saito K, Dubreuil V, Arai Y, et al. Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proc Natl Acad Sci USA 2009; 106:8350-8355.
6. Karasinska JM, Rinninger F, Lutjohann D, et al. Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J Neurosci 2009; 29:3579-3589.
7. Tozawa R, Ishibashi S, Osuga J, et al. Embryonic lethality and defective neural tube closure in mice lacking squalene synthase. J Biol Chem 1999; 274: 30843-30848.
8. Funfschilling U, Saher G, Xiao L, et al. Survival of adult neurons lacking cholesterol synthesis in vivo. BMC Neurosci 2007; 8:1.
9. Hirsch-Reinshagen V, Zhou S, Burgess BL, et al. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem 2004; 279: 41197-41207.
10. Spencer BJ, Verma IM. Targeted delivery of proteins across the blood-brain barrier. Proc Natl Acad Sci U S A 2007; 104:7594-7599.