Sustained dopaminergic response of Parkinsonism and depression in POLG-associated Parkinsonism

Movement Disorders

Volumn 25, Issue 2, 2010, Pages 243-245

  Synofzik, Matthis ^a   Asmus, Friedrich ^a   Reimold, Matthias ^b   Schöls, Ludger ^a   Berg, Daniela ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOMORPHINE; DNA DIRECTED DNA POLYMERASE GAMMA; DOPAMINE RECEPTOR STIMULATING AGENT; IODINE 123; LEVODOPA; ROPINIROLE;

ADULT; BECK DEPRESSION INVENTORY; CASE REPORT; CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; CLINICAL FEATURE; CONTROLLED STUDY; DEPRESSION; ECHOGRAPHY; EXERCISE; FAMILY HISTORY; FEMALE; GENE; GENETIC ANALYSIS; HUMAN; LETTER; MYASTHENIA GRAVIS; PARKINSONISM; POLG GENE; PRIORITY JOURNAL; PTOSIS; SCORING SYSTEM;

AFFECT; DEPRESSION; DNA-DIRECTED DNA POLYMERASE; DOPAMINE AGENTS; FEMALE; HUMANS; INDOLES; LEVODOPA; MIDDLE AGED; PARKINSONIAN DISORDERS; TREATMENT OUTCOME;

EID: 77649107297     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.22865     Document Type: Letter

References (8)

1. Luoma P, Melberg A, Rinne JO, et al. Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. Lancet 2004;364:875-882.
2. Invernizzi F, Varanese S, Thomas A, Carrara F, Onofrj M, Zeviani M. Two novel POLG1 mutations in a patient with progressive external ophthalmoplegia, levodopa-responsive pseudo-orthostatic tremor and parkinsonism. Neuromuscul Disord 2008;18:460-464.
3. Davidzon G, Greene P, Mancuso M, et al. Early-onset familial parkinsonism due to POLG mutations. Ann Neurol 2006;59:859-862.
4. Schulte C, Synofzik M, Gasser T, Schöls L. Ataxia with ophthalmoplegia or sensory neuropathy is frequently caused by POLG mutations. Neurology 2009;73:898-900.
5. Walter U, Hoeppner J, Prudente-Morrissey L, Horowski S, Herpertz SC, Benecke R. Parkinson's disease-like midbrain sonography abnormalities are frequent in depressive disorders. Brain 2007;130 (Part 7):1799-1807.
6. Bender A, Krishnan KJ, Morris CM, et al. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 2006;38:515-517.
7. Graziewicz MA, Bienstock RJ, Copeland WC. The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2′-deoxyguanosine. Hum Mol Genet 2007;16: 2729-2739.
8. Rektorova I, Balaz M, Svatova J, et al. Effects of ropinirole on nonmotor symptoms of Parkinson disease: a prospective multicenter study. Clin Neuropharmacol 2008;31:261-266.