Barriers and facilitators to antiretroviral medication adherence among HIV-infected paediatric patients in Ethiopia: A qualitative study

Sahara J

Volumn 6, Issue 4, 2009, Pages 148-154

  Biadgilign, Sibhatu ^a   Deribew, Amare ^b   Amberbir, Alemayehu ^c   Deribe, Kebede ^a  

^a John Hopkins University’s ^*  (Ethiopia)

^b JIMMA UNIVERSITY   (Ethiopia)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Adherence; Antiretroviral therapy; Children; Ethiopia; HIV AIDS

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADOLESCENT; ADULT; ARTICLE; ATTITUDE TO HEALTH; CAREGIVER; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; DEVELOPING COUNTRY; DRUG COST; ETHIOPIA; FEMALE; HEALTH CARE DELIVERY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN RELATION; INFANT; MALE; MULTICENTER STUDY; NEWBORN; PATIENT COMPLIANCE; PRESCHOOL CHILD; QUALITATIVE RESEARCH; QUESTIONNAIRE; RISK FACTOR; SOCIOECONOMICS; STATISTICS; TREATMENT REFUSAL;

ADOLESCENT; ADULT; ANTI-HIV AGENTS; ATTITUDE TO HEALTH; CAREGIVERS; CHILD; CHILD, PRESCHOOL; DEVELOPING COUNTRIES; DRUG COSTS; ETHIOPIA; FEMALE; HEALTH SERVICES ACCESSIBILITY; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMANS; INFANT; INFANT, NEWBORN; MALE; MEDICATION ADHERENCE; PROFESSIONAL-PATIENT RELATIONS; QUALITATIVE RESEARCH; QUESTIONNAIRES; RISK FACTORS; SOCIOECONOMIC FACTORS; TREATMENT REFUSAL;

EID: 77649096202     PISSN: 17290376     EISSN: 18134424     Source Type: Journal    
DOI: 10.1080/17290376.2009.9724943     Document Type: Article

References (32)

1. Adam, B. D., Maticka-Tyndale, E., & Cohen, J. J. (2003). Adherence practices among people living with HIV. AIDS Care, 15: 263-274.
2. Bangsberg, D. R., Charlebois, E. D., Grant, R. M., Holodniy, M., Deeks, S. G., Perry, S., Conroy, K. N., Clark, R., Guzman, D., Zolopa, A., & Moss, A. (2003). High levels of adherence do not prevent accumulation of HIV drug resistance mutations. AIDS, 13: 1925-1932.
3. Bangsberg, D. R., Hecht, F. M., Charlebois, E. D., Zolopa, A. R., Holodniy, M., Sheiner, L., Bamberger, J. D., Chesney, M. A., & Moss, A. (2000). Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS, 4: 357-366.
4. Bangsberg, D. R., Perry, S., Charlebois, E. D., Clark, R. A., Roberston, M., Zolopa, A. R., & Moss, A. (2001). Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS, 9: 1181-1183.
5. Bangsberg, D. R., Ware, N., & Simoni, J. M. (2006). Adherence without access to antiretroviral therapy in sub-Saharan Africa. AIDS, 20: 140-141.
6. Biadgilign, S., Deribew, A., Amberbir, A., & Kebede, D. (2008). Adherence to highly active antiretroviral therapy and its correlates among HIV infected paediatric patients in Ethiopia. BMC Paediatrics, 8: 53.
7. Byakika-Tusiime, J., Oyugi, J. H., Tumwikirize, W. A., Katabira, E. T., Mugyenyi, P. N., & Bangsberg, D. (2005). Adherence to HIV antiretroviral therapy in HIV+ Ugandan patients purchasing therapy. International Journal of STD & AIDS, 16: 38-41.
8. Catz, S. L., Kelly, J. A., Bogart, L. M., Benotsch, E. G., & McAuliffe, T. L. (2000). Patterns correlates and barriers to medication adherence among persons prescribed new treatments for HIV disease. Health Psychology, 19: 124-133.
9. Federal Ministry of Health /HIV/AIDS Prevention and Control Office (2008). Monthly HIV Care and ART Update. Federal Ministry of Health / HIV/AIDS Prevention and Control Office, Addis Ababa, Ethiopia.
10. Green, J., & Thorogood, N. (2004). Qualitative methods for health research. 1st edition. London: Sage.
11. Hogg, R. S., Heath, K. V., Yip, B., Craib, K. J., O’Shaughnessy, M. V., Schechter, M. T., & Montaner, J. S. (1998). Improved survival among HIV-infected individuals following initiation of antiretroviral therapy. JAMA, 279: 450-454.
12. Howland, L. C., Gortmaker, S. L., Mofenson, L. M., Spino, C., Gardner, J. D., Gorski, H., Fowler, M. G., & Oleske, J. (2000). Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1. Paediatrics, 106: 540-546.
13. Lanièce, I., Ciss, M., Desclaux, A., Diop, K., Mbodj, F., Ndiaye, B., Sylla, O., Delaporte, E., & Ndoye, I. (2003). Adherence to HAART and its principal determinants in a cohort of Senegalese adults. AIDS, 17 Suppl 3: S103-8.
14. Laws, M. B., Wilson, I. B., Bowser, D. M., & Kerr, S. E. (2000). Taking antiretroviral therapy for HIV infection: Learning from patients’ stories. Journal of General Internal Medicine, 15: 848-858.
15. Lyon, M. E., Trexler, C., Akpan-Townsend, C., Pao, M., Selden, K., Fletcher, J., Addlestone, I. C., & D’Angelo, L. J. (2003). A family group approach to increasing adherence to therapy in HIV infected youths: Results of a pilot project. AIDS Patient Care STDs, 17: 299-308.
16. Martinez, J., Bell, D., Camacho, R., Henry-Reid, L. M., Bell, M., Watson, C., & Rodriguez, F. (2000). Adherence to antiviral drug regiments in HIV-infected adolescent patients engaged in care in a comprehensive adolescent and young adult clinic. Journal of the National Medical Association, 92: 55-61.
17. Mills, E. J., Nachega, J. B., Bangsberg, D. R., Singh, S., Rachlis, B., Wu, P., Wilson, K., Buchan, I., Gill, C. J., & Cooper, C. (2006). Adherence to HAART: A systematic review of developed and developing nation patient reported barriers and facilitators. PLoS Medicine, 3: e438.
18. Mukherjee, J. S., Ivers, L., Leandre, F., Farmer, P., & Behforouz, H. (2006). Antiretroviral therapy in resource-poor settings. Decreasing barriers to access and promoting adherence. Journal of Acquired Immune Deficiency Syndrome, 1, 43 Suppl 1: S123-6.
19. Nachega, J. B., Stein, D. M., Lehman, D. A., Hlatshwayo, D., Mothopeng, R., Chaisson, R. E., & Karstaedt AS. (2004). Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Research and Human Retroviruses, 20: 1053-1056.
20. Nischal, K. C., Khopkar, U., & Saple, D. G. (2005). Improving adherence to antiretroviral therapy. Indian Journal of Dermatology, Venereology and Leprology, 71: 316-320.
21. Okuno, J., Yanagi, H., & Tomura, S. (2001). Is cognitive impairment a risk factor for poor compliance among Japanese elderly in the community? European Journal of Clinical Pharmacology, 57: 589-594.
22. Palella, F. J. Jr, Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., Aschman, D. J., & Holmberg, S. D. (1998). Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatients Study Investigators. New England Journal of Medicine, 338: 853-860.
23. Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., Wagener, M. M., & Singh, N. (2000). Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Annals of Internal Medicine, 1: 21-30.
24. Polit, D. F., & Beck, T. C. (2004). Nursing research: Principles and methods (7th edition). Philadelphia: Lippincott Williams & Wilkins.
25. Ryan, G., & Wagner, G. J. (2003). Pill taking ‘routinization’: A critical factor to understanding episodic medication adherence. AIDS Care, 6: 795-806.
26. Samet, J. H., Libman, H., Steger, K. A., Dhawan, R. K., Chen, J., Shevitz, A. H., Dewees-Dunk, R., Levenson, S., Kufe, D., & Craven, D. E. (1992). Compliance with zidovudine therapy in patients infected with human immunodeficiency virus type I: a cross-sectional study in a municipal hospital clinic. American Journal of Medicine, 92: 495-502.
27. Shah, C. A. (2007). Adherence to high activity antiretroviral therapy (HAART) in paediatric patients infected with HIV: Issues and Interventions. Indian Journal of Paediatrics, 74: 55-60.
28. Starace, F., Massa, A., Amico, K. R., & Fisher, J. D. (2006). Adherence to antiretroviral therapy: An empirical test of the information motivationbehavioral skills model. Health Psychology, 25: 153-162.
29. UNAIDS (2004). Report on the Global AIDS Epidemic. Geneva: UNAIDS.
30. UNAIDS/WHO (2006). AIDS Epidemic Update. Geneva: UNAIDS.
31. Weiser, S., Wolfe, W., Bangsberg, D., Thior, I., Gilbert, P., Makhema, J., Kebaabetswe, P., Dickenson, D., Mompati, K., Essex, M., & Marlink, R. (2003). Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. Journal of Acquired Immune Deficiency Syndromes, 34: 281-288.
32. Witteveen, E., & van Ameijden, E. J. C. (2002). Drug users and HIVcombination therapy (HAART): Factors with impede or facilitate adherence. Substance Use & Misuse, 14: 1905-1925.