Deregulated genes in sporadic vestibular schwannomas

Otology and Neurotology

Volumn 31, Issue 2, 2010, Pages 256-266

  Cayé Thomasen, Per ^a,b   Borup, Rehannah ^c   Stangerup, Sven Eric ^a,b   Thomsen, Jens ^a,b   Nielsen, Finn Cilius ^b,c  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Mental Health Services CPH   (Denmark)

Author keywords

Acoustic neuroma; CDNA microarray; Gene expression; Tumorigenesis; Vestibular nerve

Indexed keywords

MESSENGER RNA;

ADULT; AGED; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL ADHESION; CELL CYCLE; CELL DIFFERENTIATION; DNA MICROARRAY; EAR TUMOR; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MORPHOGENESIS; NEUROMA; PHYSIOLOGY; PROSPECTIVE STUDY; VESTIBULAR NERVE;

ADULT; AGED; APOPTOSIS; CELL ADHESION; CELL CYCLE; CELL DIFFERENTIATION; EAR NEOPLASMS; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; MORPHOGENESIS; NEUROMA, ACOUSTIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSPECTIVE STUDIES; RNA, MESSENGER; VESTIBULAR NERVE;

EID: 77649094325     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/MAO.0b013e3181be6478     Document Type: Article

References (31)

1. Rouleau GA, Merel P, Lutchman M, et al. Alteration in a new gene encoding a putative membraneYorganizing protein causes neurofibromatosis type 2. Nature 1993;363:515-21.
2. Trofatter JA, MacCollin MM, Rutter JL, et al. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 1993;75:826.
3. Sainio M, Zhao F, Heiska L. Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actincontaining cytoskeleton. J Cell Sci 1997;110:2249-60.
4. Neff BA, Welling DB, Akhmametyeva E, Chang LS. The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level. Otol Neurotol 2006;27: 197-208.
5. Welling DB, Packer MD, Chang LS. Molecular studies of vestibular schwannomas: a review. Curr Opin Otolaryngol Head Neck Surg 2007;15:341-6.
6. Welling DB, Lasak JM, Akhmametyeva E, Ghaheri B, Chang LS. cDNA microarray analysis of vestibular schwannomas. Otol Neurotol 2002;23:736-48.
7. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci U S A 2001;98:31-6.
8. Ashburner M, Ball CA, Blake JA, et al. Gene Ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 2000;25:25-9.
9. McLaughlin ME, Kruger GM, Slocum KL, et al. The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. Proc Natl Acad Sci U S A 2007;104:3261-6.
10. Herrlich P, Morrison H, Sleeman J, et al. CD44 acts both as a growth and invasiveness-promoting molecule and as a tumorsuppressing cofactor. Ann N Y Acad Sci 2000;910:106-18.
11. Sherman L, Sleeman J, Herrlich P, et al. Hyaluronate receptors: key players in growth, differentiation, migration, and tumor progression. Curr Opin Cell Biol 1994;6:726-33.
12. Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junction. Genes Dev 2003;17:1090-100.
13. Morrison H, Sherman LS, Legg J, et al. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev 2001;15:968-80.
14. Reigstad LJ, Varhaug JE, Lillehaug JR. Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family. FEBS J 2005;272: 5723-41.
15. Löttrich M, Mawrin C, Chamaon K, Kirches E, Dietzmann K, Freigang B. Expression of transforming growth factor-beta receptor type 1 and type 2 in human sporadic vestibular Schwannoma. Pathol Res Pract 2007;203:245-9.
16. Endersby R, Baker SJ. PTEN signaling in brain: neuropathology and tumorigenesis. Oncogene 2008;27:5416-30.
17. Jacob A, Lee TX, Neff BA, Miller S, Welling B, Chang LS. Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma. Otol Neurotol 2008;29:58-68.
18. Kzhyshkowska J, Gratchev A, Goerdt S. Stabilin-1, a homeostatic scavenger receptor with multiple functions. J Cell Mol Med 2006; 10:635-49.
19. Lasak JM, Welling DB, Akhmametyeva EM, Salloum M, Chang LS. Retinoblastoma-cyclinYdependent kinase pathway deregulation in vestibular schwannomas. Laryngoscope 2002;112:1555-61.
20. Neff BA, Oberstien E, Lorenz M, Chaudhury AR, Welling DB, Chang LS. Cyclin D(1) and D(3) expression in vestibular schwannomas. Laryngoscope 2006;116:423-6.
21. Lassaletta L, Patrón M, Del Río L, et al. Cyclin D1 expression and histopathologic features in vestibular schwannomas. Otol Neurotol 2007;28:939-41. (Pubitemid 47511571)
22. Hansen MR, Linthicum FH. Expression of neuregulin and activation of erbB receptors in vestibular schwannomas: possible autocrine loop stimulation. Otol Neurotol 2004;25:155-9.
23. Hansen MR, Roehm PC, Chatterjee P, Green SH. Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation. Glia 2006;53:593-600.
24. Doherty JK, Ongkeko W, Crawley B, Andalibi A, Ryan AF. ErbB and Nrg: potential molecular targets for vestibular schwannoma pharmacotherapy. Otol Neurotol 2008;29:50-7.
25. Mukobata S, Hibino T, Sugiyama A, et al. M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation. Biochem Biophys Res Commun 2002;297:722-8.
26. Michibata H, Okuno T, Konishi N, et al. Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells. Stem Cells Dev 2008; 17: 641-51.
27. Fernández ME, Cooper B, Flugge G, Frasch AC. The stressregulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation. Proc Natl Acad Sci U S A 2005;102: 17196-201.
28. Cho YY, Yao K, Kim HG, et al. Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. Cancer Res 2007;67:8104-12.
29. Cude K, Wang Y, Choi HJ, et al. Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway. J Cell Biol 2007;177:253-64.
30. Hartzell HC, Qu Z, Yu K, Xiao Q, Chien LT. Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. Physiol Rev 2008; 88: 639-72.
31. Lipshutz RJ, Fodor SP, Gingeras TR, Lockhart DJ. High density S-nthetic oligonucleotide arrays. Nat Genet 1999;21:20-4.