-
1
-
-
3042622482
-
HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
-
Owens MA, Horten BC, Da Silva MM. HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin Breast Cancer 2004;5(1):63-69
-
(2004)
Clin Breast Cancer
, vol.5
, Issue.1
, pp. 63-69
-
-
Owens, M.A.1
Horten, B.C.2
Da Silva, M.M.3
-
2
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235(4785):177-182
-
(1987)
Science
, vol.235
, Issue.4785
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
3
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353(16):1659-1672
-
(2005)
N Engl J Med
, vol.353
, Issue.16
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
-
4
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005;353(16):1673-1684
-
(2005)
N Engl J Med
, vol.353
, Issue.16
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
-
5
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344(11):783-792
-
(2001)
N Engl J Med
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
6
-
-
0033996361
-
ErbB2 potentiates breast tumor proliferation through modulation of p27 (Kip1)-Cdk2 complex formation: Receptor overexpression does not determine growth dependency
-
Lane HA, Beuvink I, Motoyama AB, et al. ErbB2 potentiates breast tumor proliferation through modulation of p27 (Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency. Mol Cell Biol 2000;20(9):3210-3223
-
(2000)
Mol Cell Biol
, vol.20
, Issue.9
, pp. 3210-3223
-
-
Lane, H.A.1
Beuvink, I.2
Motoyama, A.B.3
-
7
-
-
22244453690
-
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2
-
Longva KE, Pedersen NM, Haslekas C, et al. Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2. Int J Cancer 2005;116(3):359-367
-
(2005)
Int J Cancer
, vol.116
, Issue.3
, pp. 359-367
-
-
Longva, K.E.1
Pedersen, N.M.2
Haslekas, C.3
-
8
-
-
34547922452
-
Targeting the function of the HER2 oncogene in human cancer therapeutics
-
Moasser MM. Targeting the function of the HER2 oncogene in human cancer therapeutics. Oncogene 2007;26(46):6577-6592
-
(2007)
Oncogene
, vol.26
, Issue.46
, pp. 6577-6592
-
-
Moasser, M.M.1
-
9
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata Y, Lan KH, Zhou X, et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004;6(2):117-127
-
(2004)
Cancer Cell
, vol.6
, Issue.2
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
-
10
-
-
34447306848
-
Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
-
Valabrega G, Montemurro F, Aglietta M. Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol 2007;18(6):977-984
-
(2007)
Ann Oncol
, vol.18
, Issue.6
, pp. 977-984
-
-
Valabrega, G.1
Montemurro, F.2
Aglietta, M.3
-
11
-
-
0141787069
-
Combined trastuzumab and paclitaxel treatment better inhibits ErbB-2-mediated angiogenesis in breast carcinoma through a more effective inhibition of Akt than either treatment alone
-
Klos KS, Zhou X, Lee S, et al. Combined trastuzumab and paclitaxel treatment better inhibits ErbB-2-mediated angiogenesis in breast carcinoma through a more effective inhibition of Akt than either treatment alone. Cancer 2003;98(7):1377-1385
-
(2003)
Cancer
, vol.98
, Issue.7
, pp. 1377-1385
-
-
Klos, K.S.1
Zhou, X.2
Lee, S.3
-
12
-
-
0001223491
-
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
-
Petit AM, Rak J, Hung MC, et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 1997;151(6):1523-1530
-
(1997)
Am J Pathol
, vol.151
, Issue.6
, pp. 1523-1530
-
-
Petit, A.M.1
Rak, J.2
Hung, M.C.3
-
13
-
-
0035394833
-
Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
-
Viloria-Petit A, Crombet T, Jothy S, et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res 2001;61(13):5090-5101
-
(2001)
Cancer Res
, vol.61
, Issue.13
, pp. 5090-5101
-
-
Viloria-Petit, A.1
Crombet, T.2
Jothy, S.3
-
14
-
-
0026610881
-
Humanization of an anti-p185HER2 antibody for human cancer therapy
-
Carter P, Presta L, Gorman CM, et al. Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 1992;89(10):4285-4289
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.10
, pp. 4285-4289
-
-
Carter, P.1
Presta, L.2
Gorman, C.M.3
-
15
-
-
0034076307
-
Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
-
Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 2000;6(4):443-446
-
(2000)
Nat Med
, vol.6
, Issue.4
, pp. 443-446
-
-
Clynes, R.A.1
Towers, T.L.2
Presta, L.G.3
Ravetch, J.V.4
-
16
-
-
0344872749
-
Combination of adoptive immunotherapy with herceptin for patients with HER2-expressing breast cancer
-
Kubo M, Morisaki T, Kuroki H, et al. Combination of adoptive immunotherapy with herceptin for patients with HER2-expressing breast cancer. Anticancer Res 2003;23(6a):4443-4449
-
(2003)
Anticancer Res
, vol.23
, Issue.6 A
, pp. 4443-4449
-
-
Kubo, M.1
Morisaki, T.2
Kuroki, H.3
-
17
-
-
31444451572
-
Trastuzumab-based treatment of HER2-positive breast cancer: An antibody-dependent cellular cytotoxicity mechanism?
-
Arnould L, Gelly M, Penault-Llorca F, et al. Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism? Br J cancer 2006;94(2):259-267
-
(2006)
Br J Cancer
, vol.94
, Issue.2
, pp. 259-267
-
-
Arnould, L.1
Gelly, M.2
Penault-Llorca, F.3
-
18
-
-
4444372733
-
Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2
-
Gennari R, Menard S, Fagnoni F, et al. Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2. Clin Cancer Res 2004;10(17):5650-5655
-
(2004)
Clin Cancer Res
, vol.10
, Issue.17
, pp. 5650-5655
-
-
Gennari, R.1
Menard, S.2
Fagnoni, F.3
-
19
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999;17(9):2639-2648
-
(1999)
J Clin Oncol
, vol.17
, Issue.9
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
20
-
-
17144371333
-
Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule
-
Baselga J, Carbonell X, Castaneda-Soto NJ, et al. Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 2005;23(10):2162-2171
-
(2005)
J Clin Oncol
, vol.23
, Issue.10
, pp. 2162-2171
-
-
Baselga, J.1
Carbonell, X.2
Castaneda-Soto, N.J.3
-
21
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002;20(3):719-726
-
(2002)
J Clin Oncol
, vol.20
, Issue.3
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
22
-
-
2942659576
-
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer
-
Pegram MD, Konecny GE, O'Callaghan C, et al. Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer. J Natl Cancer Inst 2004;96(10):739-749
-
(2004)
J Natl Cancer Inst
, vol.96
, Issue.10
, pp. 739-749
-
-
Pegram, M.D.1
Konecny, G.E.2
O'Callaghan, C.3
-
23
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
Marty M, Cognetti F, Maraninchi D, et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol 2005;23(19):4265-4274
-
(2005)
J Clin Oncol
, vol.23
, Issue.19
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
24
-
-
0041885349
-
Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: Multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm
-
Burstein HJ, Harris LN, Marcom PK, et al. Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm. J Clin Oncol 2003;21(15):2889-2895
-
(2003)
J Clin Oncol
, vol.21
, Issue.15
, pp. 2889-2895
-
-
Burstein, H.J.1
Harris, L.N.2
Marcom, P.K.3
-
25
-
-
33749344930
-
Vinorelbine plus trastuzumab combination as first-line therapy for HER 2-positive metastatic breast cancer patients: An international phase II trial
-
Chan A, Martin M, Untch M, et al. Vinorelbine plus trastuzumab combination as first-line therapy for HER 2-positive metastatic breast cancer patients: an international phase II trial. Br J Cancer 2006;95(7):788-793
-
(2006)
Br J Cancer
, vol.95
, Issue.7
, pp. 788-793
-
-
Chan, A.1
Martin, M.2
Untch, M.3
-
26
-
-
0036409086
-
Phase II trial of weekly vinorelbine and trastuzumab as first-line therapy in patients with HER2(+) metastatic breast cancer
-
Jahanzeb M, Mortimer JE, Yunus F, et al. Phase II trial of weekly vinorelbine and trastuzumab as first-line therapy in patients with HER2(+) metastatic breast cancer. Oncologist 2002;7(5):410-417
-
(2002)
Oncologist
, vol.7
, Issue.5
, pp. 410-417
-
-
Jahanzeb, M.1
Mortimer, J.E.2
Yunus, F.3
-
27
-
-
34548543191
-
Capecitabine and trastuzumab in heavily pretreated metastatic breast cancer
-
Bartsch R, Wenzel C, Altorjai G, et al. Capecitabine and trastuzumab in heavily pretreated metastatic breast cancer. J Clin Oncol 2007;25(25):3853-3858
-
(2007)
J Clin Oncol
, vol.25
, Issue.25
, pp. 3853-3858
-
-
Bartsch, R.1
Wenzel, C.2
Altorjai, G.3
-
28
-
-
34548256855
-
Phase II study of capecitabine plus trastuzumab in human epidermal growth factor receptor 2 overexpressing metastatic breast cancer pretreated with anthracyclines or taxanes
-
Schaller G, Fuchs I, Gonsch T, et al. Phase II study of capecitabine plus trastuzumab in human epidermal growth factor receptor 2 overexpressing metastatic breast cancer pretreated with anthracyclines or taxanes. J Clin Oncol 2007;25(22):3246-3250
-
(2007)
J Clin Oncol
, vol.25
, Issue.22
, pp. 3246-3250
-
-
Schaller, G.1
Fuchs, I.2
Gonsch, T.3
-
29
-
-
33751423866
-
A phase II trial of trastuzumab (H) + capecitabine (X) as first-line treatment in patients (pts) with HER2-positive metastatic breast cancer
-
Xu L, Song S, Zhu J. A phase II trial of trastuzumab (H) + capecitabine (X) as first-line treatment in patients (pts) with HER2-positive metastatic breast cancer. J Clin Oncol 2006 ASCO Ann Meet Proc Part 1 2006;24(18S):10615
-
(2006)
J Clin Oncol 2006 ASCO Ann Meet Proc Part 1
, vol.24
, Issue.18 S
, pp. 10615
-
-
Xu, L.1
Song, S.2
Zhu, J.3
-
30
-
-
61749092667
-
Phase II study of gemcitabine (Gem) and trastuzumab (T) combination therapy in first line metastatic breast cancer (MBC) patients (pts) with HER2 overexpression
-
Brufsky AK, Fox K, Orlando M, et al. Phase II study of gemcitabine (Gem) and trastuzumab (T) combination therapy in first line metastatic breast cancer (MBC) patients (pts) with HER2 overexpression. J Clin Oncol 2006 ASCO Ann Meet Proc Part I 2006;24(18S):10591
-
(2006)
J Clin Oncol 2006 ASCO Ann Meet Proc Part i
, vol.24
, Issue.18 S
, pp. 10591
-
-
Brufsky, A.K.1
Fox, K.2
Orlando, M.3
-
31
-
-
3543091572
-
Phase II study of trastuzumab plus gemcitabine in chemotherapy-pretreated patients with metastatic breast cancer
-
O'Shaughnessy JA, Vukelja S, Marsland T, et al. Phase II study of trastuzumab plus gemcitabine in chemotherapy-pretreated patients with metastatic breast cancer. Clin Breast Cancer 2004;5(2):142-147
-
(2004)
Clin Breast Cancer
, vol.5
, Issue.2
, pp. 142-147
-
-
O'Shaughnessy, J.A.1
Vukelja, S.2
Marsland, T.3
-
32
-
-
36148961294
-
Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer
-
Perez EA, Romond E, Suman VJ. Updated results of the combined analysis of NCCTG N9831 and NSABP B-31 adjuvant chemotherapy with/without trastuzumab in patients with HER2-positive breast cancer. J Clin Oncol 2007;25(Suppl 18):512
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 18
, pp. 512
-
-
Perez, E.A.1
Romond, E.2
Suman, V.J.3
-
33
-
-
33845914783
-
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial
-
Smith I, Procter M, Gelber RD, et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007;369(9555):29-36
-
(2007)
Lancet
, vol.369
, Issue.9555
, pp. 29-36
-
-
Smith, I.1
Procter, M.2
Gelber, R.D.3
-
34
-
-
84927571271
-
BCIRG 006 Phase III Trial Comparing AC!T with AC!TH and with TCH in the adjuvant treatment of HER2-amplified early breast cancer patients: Third planned efficacy analysis
-
abstract 62
-
Slamon D, Eiermann W, Robert N PT, et al. BCIRG 006 Phase III Trial Comparing AC!T with AC!TH and with TCH in the adjuvant treatment of HER2-amplified early breast cancer patients: third planned efficacy analysis. Cancer Res 2009;29:abstract 62
-
(2009)
Cancer Res
, vol.29
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.P.T.3
-
35
-
-
33344478381
-
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
-
Joensuu H, Kellokumpu-Lehtinen PL, Bono P, et al. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006;354(8):809-820
-
(2006)
N Engl J Med
, vol.354
, Issue.8
, pp. 809-820
-
-
Joensuu, H.1
Kellokumpu-Lehtinen, P.L.2
Bono, P.3
-
36
-
-
74949141693
-
Trastuzumab for patients with axillary-node-positive breast cancer: Results of the FNCLCC-PACS 04 trial
-
Spielmann M, Roche H, Delozier T, et al. Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trial. J Clin Oncol 2009;27(36):6129-6134
-
(2009)
J Clin Oncol
, vol.27
, Issue.36
, pp. 6129-6134
-
-
Spielmann, M.1
Roche, H.2
Delozier, T.3
-
37
-
-
76949091692
-
Results of chemotherapy alone, with sequential or concurrent addition of 52 weeks of trastuzumab in the NCCTG N9831 HER2-positive adjuvant breast cancer trial
-
abstract 80
-
Perez EA, Suman VJ, Davidson NE, et al. Results of chemotherapy alone, with sequential or concurrent addition of 52 weeks of trastuzumab in the NCCTG N9831 HER2-positive adjuvant breast cancer trial. Cancer Res 2009;29:abstract 80
-
(2009)
Cancer Res
, vol.29
-
-
Perez, E.A.1
Suman, V.J.2
Davidson, N.E.3
-
38
-
-
0028884413
-
Requirement for neuregulin receptor erbB2 in neural and cardiac development
-
Lee KF, Simon H, Chen H, et al. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 1995;378(6555):394-398
-
(1995)
Nature
, vol.378
, Issue.6555
, pp. 394-398
-
-
Lee, K.F.1
Simon, H.2
Chen, H.3
-
39
-
-
0036099675
-
ErbB2 is essential in the prevention of dilated cardiomyopathy
-
Crone SA, Zhao YY, Fan L, et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 2002;8(5):459-465
-
(2002)
Nat Med
, vol.8
, Issue.5
, pp. 459-465
-
-
Crone, S.A.1
Zhao, Y.Y.2
Fan, L.3
-
40
-
-
2342444610
-
Essential roles of Her2/erbB2 in cardiac development and function
-
Negro A, Brar BK, Lee KF. Essential roles of Her2/erbB2 in cardiac development and function. Recent Prog Horm Res 2004;59:1-12
-
(2004)
Recent Prog Horm Res
, vol.59
, pp. 1-12
-
-
Negro, A.1
Brar, B.K.2
Lee, K.F.3
-
41
-
-
0037172982
-
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy
-
Ozcelik C, Erdmann B, Pilz B, et al. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci USA 2002;99(13):8880-8885
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.13
, pp. 8880-8885
-
-
Ozcelik, C.1
Erdmann, B.2
Pilz, B.3
-
42
-
-
12344312470
-
Neuregulin receptor ErbB2 localization at T-tubule in cardiac and skeletal muscle
-
Ueda H, Oikawa A, Nakamura A, et al. Neuregulin receptor ErbB2 localization at T-tubule in cardiac and skeletal muscle. J Histochem Cytochem 2005;53(1):87-91
-
(2005)
J Histochem Cytochem
, vol.53
, Issue.1
, pp. 87-91
-
-
Ueda, H.1
Oikawa, A.2
Nakamura, A.3
-
43
-
-
33344458106
-
Herceptin and the heart-a molecular modifier of cardiac failure
-
Chien KR. Herceptin and the heart-a molecular modifier of cardiac failure. N Engl J Med 2006;354(8):789-790
-
(2006)
N Engl J Med
, vol.354
, Issue.8
, pp. 789-790
-
-
Chien, K.R.1
-
44
-
-
32944473473
-
Trastuzumab cardiac side effects: Only time will tell
-
Levine MN. Trastuzumab cardiac side effects: only time will tell. J Clin Oncol 2005;23(31):7775-7776
-
(2005)
J Clin Oncol
, vol.23
, Issue.31
, pp. 7775-7776
-
-
Levine, M.N.1
-
45
-
-
0242721572
-
Trastuzumab and cardiac dysfunction: Update on preclinical studies
-
Klein PM, Dybdal N. Trastuzumab and cardiac dysfunction: update on preclinical studies. Semin Oncol 2003;30(5 Suppl 16):49-53
-
(2003)
Semin Oncol
, vol.30
, Issue.5 SUPPL. 16
, pp. 49-53
-
-
Klein, P.M.1
Dybdal, N.2
-
46
-
-
0035160313
-
Cardiotoxicity in signal transduction therapeutics: ErbB2 antibodies and the heart
-
Schneider JW, Chang AY, Rocco TP. Cardiotoxicity in signal transduction therapeutics: erbB2 antibodies and the heart. Semin Oncol 2001;28(5 Suppl 16):18-26
-
(2001)
Semin Oncol
, vol.28
, Issue.5 SUPPL. 16
, pp. 18-26
-
-
Schneider, J.W.1
Chang, A.Y.2
Rocco, T.P.3
-
47
-
-
0034721770
-
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species
-
Kotamraju S, Konorev EA, Joseph J, Kalyanaraman B. Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. J Biol Chem 2000;275(43):33585-33592
-
(2000)
J Biol Chem
, vol.275
, Issue.43
, pp. 33585-33592
-
-
Kotamraju, S.1
Konorev, E.A.2
Joseph, J.3
Kalyanaraman, B.4
-
48
-
-
0023264732
-
Subcellular effects of adriamycin in the heart: A concise review
-
Singal PK, Deally CM, Weinberg LE. Subcellular effects of adriamycin in the heart: a concise review. J Mol Cell Cardiol 1987;19(8):817-828
-
(1987)
J Mol Cell Cardiol
, vol.19
, Issue.8
, pp. 817-828
-
-
Singal, P.K.1
Deally, C.M.2
Weinberg, L.E.3
-
49
-
-
0032563825
-
Doxorubicininduced cardiomyopathy
-
Singal PK, Iliskovic N. Doxorubicininduced cardiomyopathy. N Engl J Med 1998;339(13):900-905
-
(1998)
N Engl J Med
, vol.339
, Issue.13
, pp. 900-905
-
-
Singal, P.K.1
Iliskovic, N.2
-
50
-
-
0030855953
-
Adriamycin cardiomyopathy: Pathophysiology and prevention
-
Singal PK, Iliskovic N, Li T, Kumar D. Adriamycin cardiomyopathy: pathophysiology and prevention. FASEB J 1997;11(12):931-936
-
(1997)
FASEB J
, vol.11
, Issue.12
, pp. 931-936
-
-
Singal, P.K.1
Iliskovic, N.2
Li, T.3
Kumar, D.4
-
51
-
-
0023130297
-
Adriamycin-stimulated hydroxyl radical formation in human breast tumor cells
-
Sinha BK, Katki AG, Batist G, et al. Adriamycin-stimulated hydroxyl radical formation in human breast tumor cells. Biochem Pharmacol 1987;36(6):793-796
-
(1987)
Biochem Pharmacol
, vol.36
, Issue.6
, pp. 793-796
-
-
Sinha, B.K.1
Katki, A.G.2
Batist, G.3
-
52
-
-
0033582464
-
Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2
-
Adderley SR, Fitzgerald DJ. Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2. J Biol Chem 1999;274(8):5038-5046
-
(1999)
J Biol Chem
, vol.274
, Issue.8
, pp. 5038-5046
-
-
Adderley, S.R.1
Fitzgerald, D.J.2
-
53
-
-
0018915753
-
Enzymatic defenses of the mouse heart against reactive oxygen metabolites: Alterations produced by doxorubicin
-
Doroshow JH, Locker GY, Myers CE. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J Clin Invest 1980;65(1):128-135
-
(1980)
J Clin Invest
, vol.65
, Issue.1
, pp. 128-135
-
-
Doroshow, J.H.1
Locker, G.Y.2
Myers, C.E.3
-
54
-
-
0034894058
-
Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo
-
Dowd NP, Scully M, Adderley SR, et al. Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo. J Clin Invest 2001;108(4):585-590
-
(2001)
J Clin Invest
, vol.108
, Issue.4
, pp. 585-590
-
-
Dowd, N.P.1
Scully, M.2
Adderley, S.R.3
-
55
-
-
3142678666
-
Cardiotoxicity associated with trastuzumab (Herceptin) therapy in the treatment of metastatic breast cancer
-
Suter TM, Cook-Bruns N, Barton C. Cardiotoxicity associated with trastuzumab (Herceptin) therapy in the treatment of metastatic breast cancer. Breast 2004;13(3):173-183
-
(2004)
Breast
, vol.13
, Issue.3
, pp. 173-183
-
-
Suter, T.M.1
Cook-Bruns, N.2
Barton, C.3
-
56
-
-
32144448027
-
Reversibility of trastuzumabrelated cardiotoxicity: New insights based on clinical course and response to medical treatment
-
Ewer MS, Vooletich MT, Durand JB, et al. Reversibility of trastuzumabrelated cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol 2005;23(31):7820-7826
-
(2005)
J Clin Oncol
, vol.23
, Issue.31
, pp. 7820-7826
-
-
Ewer, M.S.1
Vooletich, M.T.2
Durand, J.B.3
-
57
-
-
33748642331
-
Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: The MD Anderson Cancer Center experience
-
Guarneri V, Lenihan DJ, Valero V, et al. Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the MD Anderson Cancer Center experience. J Clin Oncol 2006;24(25):4107-4115
-
(2006)
J Clin Oncol
, vol.24
, Issue.25
, pp. 4107-4115
-
-
Guarneri, V.1
Lenihan, D.J.2
Valero, V.3
-
58
-
-
41649083764
-
Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial
-
Perez EA, Suman VJ, Davidson NE, et al. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol 2008;26(8):1231-1238
-
(2008)
J Clin Oncol
, vol.26
, Issue.8
, pp. 1231-1238
-
-
Perez, E.A.1
Suman, V.J.2
Davidson, N.E.3
-
59
-
-
0036498781
-
Cardiac dysfunction in the trastuzumab clinical trials experience
-
Seidman A, Hudis C, Pierri MK, et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol 2002;20(5):1215-1221
-
(2002)
J Clin Oncol
, vol.20
, Issue.5
, pp. 1215-1221
-
-
Seidman, A.1
Hudis, C.2
Pierri, M.K.3
-
60
-
-
0035873815
-
Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification
-
Seidman AD, Fornier MN, Esteva FJ, et al. Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification. J Clin Oncol 2001;19(10):2587-2595
-
(2001)
J Clin Oncol
, vol.19
, Issue.10
, pp. 2587-2595
-
-
Seidman, A.D.1
Fornier, M.N.2
Esteva, F.J.3
-
61
-
-
29744442709
-
Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31
-
Tan-Chiu E, Yothers G, Romond E, et al. Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31. J Clin Oncol 2005;23(31):7811-7819
-
(2005)
J Clin Oncol
, vol.23
, Issue.31
, pp. 7811-7819
-
-
Tan-Chiu, E.1
Yothers, G.2
Romond, E.3
-
62
-
-
36849016904
-
Five year update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/cyclophosphamide (AC) !paclitaxel (T) vs. AC ! T with trastuzumab (H)
-
Rastogi P, Jeong J, Geyer CE, et al. Five year update of cardiac dysfunction on NSABP B-31, a randomized trial of sequential doxorubicin/ cyclophosphamide (AC) !paclitaxel (T) vs. AC ! T with trastuzumab (H). J Clin Oncol 2007;25(18S):LBA513
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Rastogi, P.1
Jeong, J.2
Geyer, C.E.3
-
63
-
-
34548750753
-
Adjuvant trastuzumab: Long-term results of E2198
-
Sledge GW, O'Neill A, Thor A, et al. Adjuvant trastuzumab: long-term results of E2198. Breast Cancer Res Treat 2007;100(Suppl 1):2075
-
(2007)
Breast Cancer Res Treat
, vol.100
, Issue.SUPPL. 1
, pp. 2075
-
-
Sledge, G.W.1
O'Neill, A.2
Thor, A.3
-
64
-
-
33846297680
-
Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: An update of the initial randomized study population and data of additional patients treated with the same regimen
-
Buzdar AU, Valero V, Ibrahim NK, et al. Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen. Clin Cancer Res 2007;13(1):228-233
-
(2007)
Clin Cancer Res
, vol.13
, Issue.1
, pp. 228-233
-
-
Buzdar, A.U.1
Valero, V.2
Ibrahim, N.K.3
-
65
-
-
70249123201
-
Neoadjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer: Primary efficacy analysis of the NOAH trial
-
Gianni L, Eiermann W, Semiglazov V, et al. Neoadjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer: primary efficacy analysis of the NOAH trial. Cancer Res 2009;69(Suppl 2):31
-
(2009)
Cancer Res
, vol.69
, Issue.SUPPL. 2
, pp. 31
-
-
Gianni, L.1
Eiermann, W.2
Semiglazov, V.3
-
66
-
-
51349088475
-
Neoadjuvant trastuzumab in locally advanced breast cancer (NOAH): Antitumour and safety analysis
-
Gianni L, Semiglazov V, Manikhas GM, et al. Neoadjuvant trastuzumab in locally advanced breast cancer (NOAH): Antitumour and safety analysis. J Clin Oncol 2007;25(18S):532
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
, pp. 532
-
-
Gianni, L.1
Semiglazov, V.2
Manikhas, G.M.3
-
67
-
-
33749629577
-
Adjuvant radiotherapy (RT) and trastuzumab in stage I-IIA breast cancer: Toxicity data from North Central Cancer Treatment Group Phase III trial N9831
-
Halyard MY, Pisansky TM, Solin LJ, et al. Adjuvant radiotherapy (RT) and trastuzumab in stage I-IIA breast cancer: Toxicity data from North Central Cancer Treatment Group Phase III trial N9831. J Clin Oncol 2006;24(18S):523
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 S
, pp. 523
-
-
Halyard, M.Y.1
Pisansky, T.M.2
Solin, L.J.3
-
68
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355(26):2733-2743
-
(2006)
N Engl J Med
, vol.355
, Issue.26
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
69
-
-
44949253343
-
Cardiac safety of lapatinib: Pooled analysis of 3689 patients enrolled in clinical trials
-
Perez EA, Koehler M, Byrne J, et al. Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc 2008;83(6):679-686
-
(2008)
Mayo Clin Proc
, vol.83
, Issue.6
, pp. 679-686
-
-
Perez, E.A.1
Koehler, M.2
Byrne, J.3
-
70
-
-
73849111072
-
Pertuzumab monotherapy following trastuzumab-based treatment: Activity and tolerability in patients with advanced HER2-positive breast cancer
-
Cortës J, Baselga J, Petrella T, et al. Pertuzumab monotherapy following trastuzumab-based treatment: activity and tolerability in patients with advanced HER2-positive breast cancer. J Clin Oncol 2009;27(15S):1022
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 S
, pp. 1022
-
-
Cortës, J.1
Baselga, J.2
Petrella, T.3
-
71
-
-
65349157788
-
Results of a phase II trial of trastuzumab (H) and pertuzumab (P) in patients (pts) with HER2-positive metastatic breast cancer (MBC) who had progressed during trastuzumab therapy
-
Gelmon KA, Fumoleau P, Verma S, et al. Results of a phase II trial of trastuzumab (H) and pertuzumab (P) in patients (pts) with HER2-positive metastatic breast cancer (MBC) who had progressed during trastuzumab therapy. J Clin Oncol 2008;26:1026
-
(2008)
J Clin Oncol
, vol.26
, pp. 1026
-
-
Gelmon, K.A.1
Fumoleau, P.2
Verma, S.3
-
72
-
-
70350623516
-
A phase II study of trastuzumab-DM1 (T-DM1), a HER2 antibody-drug conjugate (ADC), in patients (pts) with HER2+ metastatic breast cancer (MBC): Final results
-
Vogel CL, Burris HA, Limentani S, et al. A phase II study of trastuzumab-DM1 (T-DM1), a HER2 antibody-drug conjugate (ADC), in patients (pts) with HER2+ metastatic breast cancer (MBC): final results. J Clin Oncol;27(15S):1017
-
J Clin Oncol
, vol.27
, Issue.15 S
, pp. 1017
-
-
Vogel, C.L.1
Burris, H.A.2
Limentani, S.3
-
73
-
-
73849142191
-
Neratinib in combination with trastuzumab for the treatment of advanced breast cancer: A phase I/II study
-
Swaby R, Blackwell K, Jiang Z, et al. Neratinib in combination with trastuzumab for the treatment of advanced breast cancer: a phase I/II study. J Clin Oncol;27(15S):1004
-
J Clin Oncol
, vol.27
, Issue.15 S
, pp. 1004
-
-
Swaby, R.1
Blackwell, K.2
Jiang, Z.3
-
74
-
-
70149085341
-
PI3 kinase activation and response to trastuzumab or lapatinib in HER-2 overexpressing locally advanced breast cancer (LABC)
-
Migliaccio IGM, Wu M-F, Wong H, et al. PI3 kinase activation and response to trastuzumab or lapatinib in HER-2 overexpressing locally advanced breast cancer (LABC). Cancer Res 2009;69(Suppl 2):34
-
(2009)
Cancer Res
, vol.69
, Issue.SUPPL. 2
, pp. 34
-
-
Migliaccio, I.G.M.1
Wu, M.-F.2
Wong, H.3
-
75
-
-
77949721591
-
Updated Survival analysis of a randomized study of lapatinib alone or in combination with trastuzumab in women with HER2-positive metastatic breast cancer progressing on trastuzumab therapy
-
abstract 61
-
Blackwell K, Burstein HJ, Sledge G, et al. Updated Survival analysis of a randomized study of lapatinib alone or in combination with trastuzumab in women with HER2-positive metastatic breast cancer progressing on trastuzumab therapy. Cancer 2009;29:abstract 61
-
(2009)
Cancer
, vol.29
-
-
Blackwell, K.1
Burstein, H.J.2
Sledge, G.3
-
76
-
-
1842543455
-
HER2-overexpressing human breast cancer xenografts exhibit increased angiogenic potential mediated by vascular endothelial growth factor (VEGF)
-
Epstein M, Ayala R, Tchekmedian N, Borgstrom P, et al. HER2-overexpressing human breast cancer xenografts exhibit increased angiogenic potential mediated by vascular endothelial growth factor (VEGF). Breast Cancer Res Treat 2002;76:S143
-
(2002)
Breast Cancer Res Treat
, vol.76
-
-
Epstein, M.1
Ayala, R.2
Tchekmedian, N.3
Borgstrom, P.4
-
77
-
-
12144291334
-
Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
-
Konecny GE, Meng YG, Untch M, et al. Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 2004;10(5):1706-1716
-
(2004)
Clin Cancer Res
, vol.10
, Issue.5
, pp. 1706-1716
-
-
Konecny, G.E.1
Meng, Y.G.2
Untch, M.3
-
78
-
-
0034691674
-
Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis
-
Yen L, You XL, Al Moustafa AE, et al. Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. Oncogene 2000;19(31):3460-3469
-
(2000)
Oncogene
, vol.19
, Issue.31
, pp. 3460-3469
-
-
Yen, L.1
You, X.L.2
Al Moustafa, A.E.3
-
79
-
-
77649134730
-
Final results of a phase II trial evaluating trastuzumab and bevacizumab as first line treatment of HER2-amplified advanced breast cancer
-
abstract 6094
-
Hurvitz SA, Pegram MD, Lin L-S, et al. Final results of a phase II trial evaluating trastuzumab and bevacizumab as first line treatment of HER2-amplified advanced breast cancer. Cancer Res 2009;29:abstract 6094
-
(2009)
Cancer Res
, vol.29
-
-
Hurvitz, S.A.1
Pegram, M.D.2
Lin, L.-S.3
-
80
-
-
33746172167
-
Antibody targeting of longcirculating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
-
Kirpotin DB, Drummond DC, Shao Y, et al. Antibody targeting of longcirculating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 2006;66(13):6732-6740
-
(2006)
Cancer Res
, vol.66
, Issue.13
, pp. 6732-6740
-
-
Kirpotin, D.B.1
Drummond, D.C.2
Shao, Y.3
-
81
-
-
0036554863
-
Anti-HER2 immunoliposomes: Enhanced efficacy attributable to targeted delivery
-
Park JW, Hong K, Kirpotin DB, et al. Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery. Clin Cancer Res 2002;8(4):1172-1181
-
(2002)
Clin Cancer Res
, vol.8
, Issue.4
, pp. 1172-1181
-
-
Park, J.W.1
Hong, K.2
Kirpotin, D.B.3
-
82
-
-
35848961893
-
Antitumor effect of paclitaxel-loaded PEGylated immunoliposomes against human breast cancer cells
-
Yang T, Choi MK, Cui FD, et al. Antitumor effect of paclitaxel-loaded PEGylated immunoliposomes against human breast cancer cells. Pharm Res 2007;24(12):2402-2411
-
(2007)
Pharm Res
, vol.24
, Issue.12
, pp. 2402-2411
-
-
Yang, T.1
Choi, M.K.2
Cui, F.D.3
|