Depletion of spinal 5-HT accelerates mechanosensory recovery in the deafferented rat spinal cord

Experimental Neurology

Volumn 222, Issue 2, 2010, Pages 277-284

  Cragg, J J ^a   Scott, A L ^a   Ramer, M S ^a  

^a INTERNATIONAL COLLABORATION ON REPAIR DISCOVERIES   (Canada)

Author keywords

5,7 Dihydroxytryptamine; Dorsal rhizotomy; Dorsal root injury; Serotonin

Indexed keywords

5,7 DIHYDROXYTRYPTAMINE; BRAIN DERIVED NEUROTROPHIC FACTOR; NEUROPEPTIDE Y; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; COLD SENSITIVITY; CONTROLLED STUDY; DEAFFERENTATION; DORSAL RHIZOTOMY; DORSAL ROOT; INTERNEURON; MALE; MECHANOTRANSDUCTION; MICROGLIA; NERVE INJURY; NERVE PROJECTION; NERVE SPROUTING; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SEROTONINERGIC NERVE CELL; SPINAL CORD DORSAL HORN;

5,7-DIHYDROXYTRYPTAMINE; ANIMALS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALCITONIN GENE-RELATED PEPTIDE; DISEASE MODELS, ANIMAL; HYPERALGESIA; HYPESTHESIA; LECTINS; MALE; MICROGLIA; NEUROPEPTIDE Y; PAIN THRESHOLD; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; RHIZOTOMY; SEROTONIN; SEROTONIN AGENTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPINAL CORD; SPINAL NERVE ROOTS; TYROSINE 3-MONOOXYGENASE; UP-REGULATION; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1;

EID: 77549087222     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2010.01.005     Document Type: Article

References (42)

1. Alhaider A.A., Lei S.Z., and Wilcox G.L. Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA. J. Neurosci. 11 (1991) 1881-1888
2. Baker-Herman T.L., Fuller D.D., Bavis R.W., Zabka A.G., Golder F.J., Doperalski N.J., Johnson R.A., Watters J.J., and Mitchell G.S. BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Nat. Neurosci. 7 (2004) 48-55
3. Barde Y.A., Edgar D., and Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1 (1982) 549-553
4. Bradbury E.J., Moon L.D., Popat R.J., King V.R., Bennett G.S., Patel P.N., Fawcett J.W., and McMahon S.B. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416 (2002) 636-640
5. Braun M., Wendt A., Karanauskaite J., Galvanovskis J., Clark A., MacDonald P.E., and Rorsman P. Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells. J. Gen. Physiol. 129 (2007) 221-231
6. Brumovsky P., Hofstetter C., Olson L., Ohning G., Villar M., and Hokfelt T. The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord. Neuroscience 138 (2006) 1361-1376
7. Chaudhry F.A., Reimer R.J., Bellocchio E.E., Danbolt N.C., Osen K.K., Edwards R.H., and Storm-Mathisen J. The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons. J. Neurosci. 18 (1998) 9733-9750
8. Daniele C.A., and MacDermott A.B. Low-threshold primary afferent drive onto GABAergic interneurons in the superficial dorsal horn of the mouse. J. Neurosci. 29 (2009) 686-695
9. Hentall I.D., Pinzon A., and Noga B.R. Spatial and temporal patterns of serotonin release in the rat's lumbar spinal cord following electrical stimulation of the nucleus raphe magnus. Neurosci. 142 (2006) 893-903
10. Howe J.R., and Yaksh T.L. Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5,6-dihydroxytryptamine (5,6-DHT) or repeated monoamine administration. J. Pharmacol. Exp. Ther. 220 (1981) 311-321
11. Jo Y.H., and Schlichter R. Synaptic corelease of ATP and GABA in cultured spinal neurons. Nat. Neurosci. 2 (1999) 241-245
12. Kiehn O., Erdal J., Eken T., and Bruhn T. Selective Depletion of spinal monoamines changes the rat soleus EMG from a tonic to a more phasic pattern. J. Physiol. 492 (1996) 173-184
13. Kut J.L., Young M.R., Crayton J.W., Wright M.A., and Young M.E. Regulation of murine T-lymphocyte function by spleen cell-derived and exogenous serotonin. Immunopharmacol. Immunotoxicol. 14 (1992) 783-796
14. Levy R.A. The role of GABA in primary afferent depolarization. Prog. Neurobiol. 9 (1977) 211-267
15. Mahe C., Loetscher E., Dev K.K., Bobirnac I., Otten U., and Schoeffter P. Serotonin 5-HT7 receptors coupled to induction of interleukin-6 in human microglial MC-3 cells. Neuropharmacology 49 (2005) 40-47
16. Marson L., and McKenna K.E. Serotonergic neurotoxic lesions facilitate male sexual reflexes. Pharm. Biochem. Behav. 47 (1993) 883-888
17. Millan M.J. Descending control of pain. Prog. Neurobiol. 66 (2002) 355-474
18. Morales M., McCollum N., and Kirkness E.F. 5-HT(3)-receptor subunits A and B are co-expressed in neurons of the dorsal root ganglion. J. Comp. Neurol. 438 (2001) 163-172
19. Mossner R., and Lesch K.P. Role of serotonin in the immune system and in neuroimmune interactions. Brain Behav. Immun. 12 (1998) 249-271
20. Nicholson R., Small J., Dixon A.K., Spanswick D., and Lee K. Serotonin receptor mRNA expression in rat dorsal root ganglion neurons. Neurosci. Lett. 337 (2003) 119-122
21. Oatway M.A., Chen Y., and Weaver L.C. The 5-HT3 receptor facilitates at-level mechanical allodynia following spinal cord injury. Pain 110 (2004) 259-268
22. Polgar E., Shehab S.A., Watt C., and Todd A.J. GABAergic neurons that contain neuropeptide Y selectively target cells with the neurokinin 1 receptor in laminae III and IV of the rat spinal cord. J. Neurosci. 19 (1999) 2637-2646
23. Prusky G.T., Harker K.T., Douglas R.M., and Whishaw I.Q. Variation in visual acuity within pigmented, and between pigmented and albino rat strains. Behav. Brain Res. 136 (2002) 339-348
24. Rahman W., Suzuki R., Webber M., Hunt S.P., and Dickenson A.H. Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation. Pain 123 (2006) 264-274
25. Ramer L.M., Borisoff J.F., and Ramer M.S. Rho-kinase inhibition enhances axonal plasticity and attenuates cold hyperalgesia after dorsal rhizotomy. J. Neurosci. 24 (2004) 10796-10805
26. Ramer L.M., McPhail L.T., Borisoff J.F., Soril L.J., Kaan T.K., Lee J.H., Saunders J.W., Hwi L.P., and Ramer M.S. Endogenous TrkB ligands suppress functional mechanosensory plasticity in the deafferented spinal cord. J. Neurosci. 27 (2007) 5812-5822
27. Rowan S., Todd A.J., and Spike R.C. Evidence that neuropeptide Y is present in GABAergic neurons in the superficial dorsal horn of the rat spinal cord. Neuroscience 53 (1993) 537-545
28. Rowland N.E., Kalehua A.N., Li B.H., Semple-Rowland S.L., and Streit W.J. Loss of serotonin uptake sites and immunoreactivity in rat cortex after dexfenfluramine occur without parallel glial cell reactions. Brain Res. 624 (1993) 35-43
29. Sawynok J., and Reid A. Spinal supersensitivity to 5-HT1, 5-HT2 and 5-HT3 receptor agonists following 5,7-dihydroxytryptamine. Eur. J. Pharmacol. 264 (1994) 249-257
30. Scott A.L., Borisoff J.F., and Ramer M.S. Deafferentation and neurotrophin-mediated intraspinal sprouting: a central role for the p75 neurotrophin receptor. Eur. J. Neurosci. 21 (2005) 81-92
31. Soril L.J., Ramer L.M., McPhail L.T., Kaan T.K., and Ramer M.S. Spinal brain-derived neurotrophic factor governs neuroplasticity and recovery from cold-hypersensitivity following dorsal rhizotomy. Pain 138 (2008) 98-110
32. Sperlagh B., Sershen H., Lajtha A., and Vizi E.S. Co-release of endogenous ATP and [3H]noradrenaline from rat hypothalamic slices: origin and modulation by alpha2-adrenoceptors. Neuroscience 82 (1998) 511-520
33. Suzuki R., Morcuende S., Webber M., Hunt S.P., and Dickenson A.H. Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat. Neurosci. 5 (2002) 1319-1326
34. Tork I. Anatomy of the serotonergic system. Ann. N.Y. Acad. Sci. 600 (1990) 9-34 discussion 34-5
35. Torsney C., and MacDermott A.B. Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord. J. Neurosci. 26 (2006) 1833-1843
36. Trang T., Beggs S., Wan X., and Salter M.W. P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J. Neurosci. 29 (2009) 3518-3528
37. Vanegas H., and Schaible H.G. Descending control of persistent pain: inhibitory or facilitatory?. Brain Res. Brain Res. Rev. 46 (2004) 295-309
38. Wall P.D. Do nerve impulses penetrate terminal arborizations? A pre-presynaptic control mechanism. Trends Neurosci. 18 (1995) 99-103
39. Wall P.D., and Bennett D.L. Postsynaptic effects of long-range afferents in distant segments caudal to their entry point in rat spinal cord under the influence of picrotoxin or strychnine. J. Neurophysiol. 72 (1994) 2703-2713
40. Wall P.D., and McMahon S.B. Long range afferents in rat spinal cord. III. Failure of impulse transmission in axons and relief of the failure after rhizotomy of dorsal roots. Philos. Trans. R. Soc. Lond. B Biol. Sci. 343 (1994) 211-223
41. Young M.R., and Matthews J.P. Serotonin regulation of T-cell subpopulations and of macrophage accessory function. Immunology 84 (1995) 148-152
42. Young M.R., Kut J.L., Coogan M.P., Wright M.A., Young M.E., and Matthews J. Stimulation of splenic T-lymphocyte function by endogenous serotonin and by low-dose exogenous serotonin. Immunology 80 (1993) 395-400