The decrease of expression of ryanodine receptor sub-type 2 is reversed by gentamycin sulphate in vascular myocytes from mdx mice

Journal of Cellular and Molecular Medicine

Volumn 13, Issue 9 B, 2009, Pages 3122-3130

  Morel, Jean Luc ^a   Dabertrand, Fabrice ^a   Fritz, Nicolas ^b   Henaff, Morgana ^a   Mironneau, Jean ^a   Macrez, Nathalie ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Calcium signalling; Gentamycin; Mdx; Muscular dystrophy; Ryanodine receptor; Smooth muscle; Vascular myocyte

Indexed keywords

CALCIUM; DYSTROPHIN; GENTAMICIN; MESSENGER RNA; RYANODINE RECEPTOR; SULFATE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CALCIUM SIGNALING; CYTOLOGY; GENE EXPRESSION REGULATION; METABOLISM; MOUSE; MUSCLE CELL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ANIMALS; CALCIUM; CALCIUM SIGNALING; DYSTROPHIN; GENE EXPRESSION REGULATION; GENTAMICINS; MICE; MICE, INBRED MDX; MUSCLE CELLS; MUSCLE, SMOOTH; RNA, MESSENGER; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SIGNAL TRANSDUCTION; SULFATES;

MUS;

EID: 77449153149     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00718.x     Document Type: Article

References (39)

1. Gillis JM. Understanding dystrophinopathies: an inventory of the structural and functional consequences of the absence of dystrophin in muscles of the mdx mouse. J Muscle Res Cell Motil. 1999, 20:605-25.
2. Turner PR, Westwood T, Regen CM. Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice. Nature. 1988, 335:735-8.
3. Bakker AJ, Head SI, Williams DA. Ca2+ levels in myotubes grown from the skeletal muscle of dystrophic (mdx) and normal mice. J Physiol. 1993, 460:1-13.
4. Head SI, Williams DA, Stephenson DG. Abnormalities in structure and function of limb skeletal muscle fibres of dystrophic mdx mice. Proc Biol Sci. 1992, 248:163-9.
5. Rivet-Bastide M, Imbert N, Cognard C. Changes in cytosolic resting ionized calcium level and in calcium transients during in vitro development of normal and Duchenne muscular dystrophy cultured skeletal muscle measured by laser cytofluorometry using indo-1. Cell Calcium 1993, 14:563-71.
6. Miyatake M, Miike T, Yoshioka K. Possible systemic smooth muscle layer dysfunction due to a deficiency of dystrophin in Duchenne muscular dystrophy. J Neurol Sci. 1989, 93:11-7.
7. Takeshima H, Iino M, Takekura H. Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene. Nature. 1994, 369:556-9.
8. Takeshima H, Komazaki S, Hirose K. Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2. EMBO J. 1998, 17:3309-16.
9. Coussin F, Macrez N, Morel JL. Requirement of ryanodine receptor subtypes 1 and 2 for Ca2+-induced Ca2+ release in vascular myocytes. J Biol Chem. 2000, 275:9596-603.
10. Mironneau J, Coussin F, Morel JL. Calcium signalling through nucleotide receptor P2×1 in rat portal vein myocytes. J Physiol. 2001, 536:339-50.
11. Morel JL, Rakotoarisoa L, Jeyakumar LH. Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes. J Biol Chem. 2004, 279:21287-93.
12. Rohman MS, Emoto N, Takeshima Y. Decreased mAKAP, ryanodine receptor, and SERCA2a gene expression in mdx hearts. Biochem Biophys Res Commun. 2003, 310:228-35.
13. Williams IA, Allen DG. Intracellular calcium handling in ventricular myocytes from mdx mice. Am J Physiol 2007, 292:H846-55.
14. Mancinelli R, Tonali P, Romani R. Mechanical properties of smooth muscle portal vein in normal and dystrophin-deficient (mdx) mice. Exp Physiol. 1999, 84:929-40.
15. Sicinski P, Rowiński J, Warchoł JB. The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. Science. 1989, 244:1578-80.
16. Burke JF, Mogg AE. Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin. Nucleic Acids Res. 1985, 13:6265-72.
17. Barton-Davis ER, Cordier L, Shoturma DI. Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice. J Clin Invest. 1999, 104:375-81.
18. Loufrani L, Dubroca C, You D. Absence of dystrophin in mice reduces NO-dependent vascular function and vascular density: total recovery after a treatment with the aminoglycoside gentamicin. Arterioscler Thromb Vasc Biol. 2004, 24:671-6.
19. Kimura S, Ito K, Miyagi T. A novel approach to identify Duchenne muscular dystrophy patients for aminoglycoside antibiotics therapy. Brain Dev. 2005, 27:400-5.
20. Fritz N, Mironneau J, Macrez N. Acetylcholine-induced Ca2+ oscillations are modulated by a Ca2+ regulation of InsP3R2 in rat portal vein myocytes. Pflugers Arch. 2008, 456:277-83.
21. Fritz N, Macrez N, Mironneau J. Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose signalling pathway in duodenum myocytes. J Cell Sci. 2005, 118:2261-70.
22. Dabertrand F, Morel JL, Sorrentino V. Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells. Cell Calcium. 2006, 40:11-21.
23. Dabertrand F, Fritz N, Mironneau J. Role of RYR3 splice variants in calcium signaling in mouse non-pregnant and pregnant myometrium. Am J Physiol Cell Physiol 2007, 293:C848-54.
24. Jiang D, Xiao B, Li X. Smooth muscle tissues express a major dominant negative splice variant of the type 3 Ca2+ release channel (ryanodine receptor). J Biol Chem. 2003, 278:4763-9.
25. Fritz N, Morel JL, Jeyakumar LH. RyR1-specific requirement for depolarization-induced Ca2+ sparks in urinary bladder smooth muscle. J Cell Sci. 2007, 120:3784-91.
26. Mironneau J, Arnaudeau S, Macrez-Lepretre N. Ca2+ sparks and Ca2+ waves activate different Ca2+-dependent ion channels in single myocytes from rat portal vein. Cell Calcium. 1996, 20:153-60.
27. Nelson MT, Cheng H, Rubart M. Relaxation of arterial smooth muscle by calcium sparks. Science. 1995, 270:633-7.
28. Thomas GD, Sander M, Lau KS. Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscle. Proc Natl Acad Sci USA. 1998, 95:15090-5.
29. Sander M, Chavoshan B, Harris SA. Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy. Proc Natl Acad Sci USA. 2000, 97:13818-23.
30. Dye WW, Gleason RL, Wilson E. Altered biomechanical properties of carotid arteries in two mouse models of muscular dystrophy. J Appl Physiol. 2007, 103:664-72.
31. Woods CE, Novo D, DiFranco M. The action potential-evoked sarcoplasmic reticulum calcium release is impaired in mdx mouse muscle fibres. J Physiol. 2004, 557:59-75.
32. Wang X, Weisleder N, Collet C. Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Nat Cell Biol. 2005, 7:525-30.
33. Deconinck N, Dan B. Pathophysiology of Duchenne muscular dystrophy: current hypotheses. Pediatr Neurol. 2007, 36:1-7.
34. Morel JL, Boittin FX, Halet G. Effect of a 14-day hindlimb suspension on cytosolic Ca2+ concentration in rat portal vein myocytes. Am J Physiol 1997, 273:H2867-75.
35. Loufrani L, Henrion D. Vasodilator treatment with hydralazine increases blood flow in mdx mice resistance arteries without vascular wall remodelling or endothelium function improvement. J Hypertens. 2005, 23:1855-60.
36. Howard M, Frizzell RA, Bedwell DM. Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations. Nat Med. 1996, 2:467-9.
37. Sermet-Gaudelus I, Renouil M, Fajac A. In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study. BMC Med. 2007, 5:5.
38. Bidou L, Hatin I, Perez N. Premature stop codons involved in muscular dystrophies show a broad spectrum of readthrough efficiencies in response to gentamicin treatment. Gene Ther. 2004, 11:619-27.
39. Ito K, Kimura S, Ozasa S. Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice. Hum Mol Genet. 2006, 15:2266-75.