Allogeneic stem cell transplantation for patients with refractory anaemia with matched related and unrelated donors: Delay of the transplant is associated with inferior survival

British Journal of Haematology

Volumn 146, Issue 6, 2009, Pages 627-636

  Witte, Theo de ^a   Brand, Ronald ^b   Biezen, Anja van ^b   Mufti, Ghulam ^c   Ruutu, Tapani ^d   Finke, Jürgen ^e   Borne, Peter von dem ^b   Vitek, Antonin ^f   Delforge, Michel ^g   Alessandrino, Paolo ^h   Harlahakis, Nicolas ⁱ   Russell, Nigel ^j   Martino, Roberto ^k   Verdonck, Leo ^l   Kröger, Nicholas ^m   Niederwieser, Dietger ⁿ  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e UNIVERSITY OF FREIBURG   (Germany)

^f INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION   (Czech Republic)

^g UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^h FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

ⁱ EVANGELISMOS HOSPITAL   (Greece)

^j NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^k HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^l UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^m UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

ⁿ UNIVERSITY OF LEIPZIG   (Germany)

more..

Author keywords

Allogeneic stem cell transplantation; Hla Identical sibling donor; Matched unrelated donor.; Reduced intensity conditioning regimens; Refractory anaemia

Indexed keywords

ADULT; ARTICLE; DISEASE FREE SURVIVAL; DONOR; FEMALE; HISTOCOMPATIBILITY TEST; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MALE; METHODOLOGY; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; REFRACTORY ANEMIA; RISK FACTOR; SIBLING; STATISTICS; STEM CELL TRANSPLANTATION; TIME;

ADULT; ANEMIA, REFRACTORY; DISEASE-FREE SURVIVAL; FEMALE; HISTOCOMPATIBILITY TESTING; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RISK FACTORS; SIBLINGS; STEM CELL TRANSPLANTATION; TIME FACTORS; TISSUE DONORS; TRANSPLANTATION CONDITIONING; YOUNG ADULT;

EID: 77449147495     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07809.x     Document Type: Article

References (33)

1. Alessandrino, E.P., la Porta, M.G., Bacigalupo, A., Van Lint, M.T., Falda, M., Onida, F., Bernardi, M., Iori, A.P., Rambaldi, A., Cerretti, R., Marenco, P., Pioltelli, P., Malcovati, L., Pascutto, C., Oneto, R., Fanin, R. & Bosi, A. (2008) WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO). Blood, 112, 895-902.
2. Anderson, J.E., Appelbaum, F.R., Schoch, G., Gooley, T., Anasetti, C., Bensinger, W.I., Bryant, E., Buckner, C.D., Chauncey, T.R., Clift, R.A., Doney, K., Flowers, M., Hansen, J.A., Martin, P.J., Matthews, D.C., Sanders, J.E., Shulman, H., Sullivan, K.M., Witherspoon, R.P. & Storb, R. (1996) Allogeneic marrow transplantation for refractory anemia: a comparison of two preparative regimens and analysis of prognostic factors. Blood, 87, 51-58.
3. Arnold, R., de Witte, T., van Biezen, A., Hermans, J., Jacobsen, N., Runde, V., Gratwohl, A. & Apperley, J.F. (1998) Unrelated bone marrow transplantation in patients with myelodysplastic syndromes and secondary acute myeloid leukemia: an EBMT survey. European Blood and Marrow Transplantation Group. Bone Marrow Transplantation, 21, 1213-1216.
4. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A., Gralnick, H.R. & Sultan, C. (1982) Proposals for the classification of the myelodysplastic syndromes. British Journal of Haematology, 51, 189-199.
5. Castro-Malaspina, H., Harris, R.E., Gajewski, J., Ramsay, N., Collins, R., Dharan, B., King, R. & Deeg, H.J. (2002) Unrelated donor marrow transplantation for myelodysplastic syndromes: outcome analysis in 510 transplants facilitated by the National Marrow Donor Program. Blood, 99, 1943-1951.
6. Couban, S., Simpson, D.R., Barnett, M.J., Bredeson, C., Hubesch, L., Howson-Jan, K., Shore, T.B., Walker, I.R., Browett, P., Messner, H.A., Panzarella, T. & Lipton, J.H. (2002) A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies. Blood, 100, 1525-1531.
7. Cutler, C.S., Lee, S.J., Greenberg, P., Deeg, H.J., Perez, W.S., Anasetti, C., Bolwell, B.J., Cairo, M.S., Gale, R.P., Klein, J.P., Lazarus, H.M., Liesveld, J.L., McCarthy, P.L., Milone, G.A., Rizzo, J.D., Schultz, K.R., Trigg, M.E., Keating, A., Weisdorf, D.J., Antin, J.H. & Horowitz, M.M. (2004) A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome. Blood, 104, 579-585.
8. Deeg, H.J., Shulman, H.M., Anderson, J.E., Bryant, E.M., Gooley, T.A., Slattery, J.T., Anasetti, C., Fefer, A., Storb, R. & Appelbaum, F.R. (2000) Allogeneic and syngeneic marrow transplantation for myelodysplastic syndrome in patients 55 to 66 years of age. Blood, 95, 1188-1194.
9. Deeg, H.J., Storer, B., Slattery, J.T., Anasetti, C., Doney, K.C., Hansen, J.A., Kiem, H.P., Martin, P.J., Petersdorf, E., Radich, J.P., Sanders, J.E., Shulman, H.M., Warren, E.H., Witherspoon, R.P., Bryant, E.M., Chauncey, T.R., Getzendaner, L., Storb, R. & Appelbaum, F.R. (2002) Conditioning with targeted busulfan and cyclophosphamide for hemopoietic stem cell transplantation from related and unrelated donors in patients with myelodysplastic syndrome. Blood, 100, 1201-1207.
10. Demuynck, H., Verhoef, G.E., Zachee, P., Emonds, M.P., van der Schueren, E., van den Berghe, H., Vandenberghe, P., Casteels-Van, D.M. & Boogaerts, M.A. (1996) Treatment of patients with myelodysplastic syndromes with allogeneic bone marrow transplantation from genotypically HLA-identical sibling and alternative donors. Bone Marrow Transplantation, 17, 745-751.
11. Greenberg, P., Cox, C., LeBeau, M.M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., Ohyashiki, K., Toyama, K., Aul, C., Mufti, G. & Bennett, J. (1997) International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood, 89, 2079-2088.
12. Guardiola, P., Runde, V., Bacigalupo, A., Ruutu, T., Locatelli, F., Boogaerts, M.A., Pagliuca, A., Cornelissen, J.J., Schouten, H.C., Carreras, E., Finke, J., van Biezen, A., Brand, R., Niederwieser, D., Gluckman, E. & de Witte, T.M. (2002) Retrospective comparison of bone marrow and granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells for allogeneic stem cell transplantation using HLA identical sibling donors in myelodysplastic syndromes. Blood, 99, 4370-4378.
13. Hellstrom-Lindberg, E., Negrin, R., Stein, R., Krantz, S., Lindberg, G., Vardiman, J., Ost, A. & Greenberg, P. (1997) Erythroid response to treatment with G-CSF plus erythropoietin for the anaemia of patients with myelodysplastic syndromes: proposal for a predictive model. British Journal of Haematology, 99, 344-351.
14. Janssen, J.W., Buschle, M., Layton, M., Drexler, H.G., Lyons, J., van den Berghe, H., Heimpel, H., Kubanek, B., Kleihauer, E. & Mufti, G.J. (1989) Clonal analysis of myelodysplastic syndromes: evidence of multipotent stem cell origin. Blood, 73, 248-254.
15. Kroger, N., Bornhauser, M., Ehninger, G., Schwerdtfeger, R., Biersack, H., Sayer, H.G., Wandt, H., Schafer-Eckardt, K., Beyer, J., Kiehl, M. & Zander, A.R. (2003) Allogeneic stem cell transplantation after a fludarabine/busulfan-based reduced-intensity conditioning in patients with myelodysplastic syndrome or secondary acute myeloid leukemia. Annals of Hematology, 82, 336-342.
16. Malcovati, L., Porta, M.G., Pascutto, C., Invernizzi, R., Boni, M., Travaglino, E., Passamonti, F., Arcaini, L., Maffioli, M., Bernasconi, P., Lazzarino, M. & Cazzola, M. (2005) Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making. Journal of Clinical Oncology, 23, 7594-7603.
17. Malcovati, L., Germing, U., Kuendgen, A., la Porta, M.G., Pascutto, C., Invernizzi, R., Giagounidis, A., Hildebrandt, B., Bernasconi, P., Knipp, S., Strupp, C., Lazzarino, M., Aul, C. & Cazzola, M. (2007) Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. Journal of Clinical Oncology, 25, 3503-3510.
18. Maris, M.B., Niederwieser, D., Sandmaier, B.M., Storer, B., Stuart, M., Maloney, D., Petersdorf, E., McSweeney, P., Pulsipher, M., Woolfrey, A., Chauncey, T., Agura, E., Heimfeld, S., Slattery, J., Hegenbart, U., Anasetti, C., Blume, K. & Storb, R. (2003) HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with hematologic malignancies. Blood, 102, 2021-2030.
19. Martino, R., Caballero, M.D., Simon, J.A., Canals, C., Solano, C.,Urbano- Ispizua, A., Bargay, J., Leon, A., Sarra, J., Sanz, G.F., Moraleda, J.M., Brunet, S., San, M.J. & Sierra, J. (2002) Evidence for a graft-versusleukemia effect after allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning in acute myelogenous leukemia and myelodysplastic syndromes. Blood, 100, 2243-2245.
20. Mattijssen, V., Schattenberg, A., Schaap, N., Preijers, F. & de Witte, T. (1997) Outcome of allogeneic bone marrow transplantation with lymphocyte-depleted marrow grafts in adult patients with myelodysplastic syndromes. Bone Marrow Transplantation, 19, 791-794.
21. Molldrem, J.J., Leifer, E., Bahceci, E., Saunthararajah, Y., Rivera, M., Dunbar, C., Liu, J., Nakamura, R., Young, N.S. & Barrett, A.J. (2002) Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes. Annals of Internal Medicine, 137, 156-163.
22. Nevill, T.J., Fung, H.C., Shepherd, J.D., Horsman, D.E., Nantel, S.H., Klingemann, H.G., Forrest, D.L., Toze, C.L., Sutherland, H.J., Hogge, D.E., Naiman, S.C., Le, A., Brockington, D.A. & Barnett, M.J. (1998) Cytogenetic abnormalities in primary myelodysplastic syndrome are highly predictive of outcome after allogeneic bone marrow transplantation. Blood, 92, 1910-1917.
23. Parker, J.E., Shafi, T., Pagliuca, A., Mijovic, A., Devereux, S., Potter, M., Prentice, H.G., Garg, M., Yin, J.A., Byrne, J., Russell, N.H. & Mufti, G.J. (2002) Allogeneic stem cell transplantation in the myelodysplastic syndromes: interim results of outcome following reduced-intensity conditioning compared with standard preparative regimens. British Journal of Haematology, 119, 144-154.
24. Putter, H., Fiocco, M. & Geskus, R.B. (2007) Tutorial in biostatistics: competing risks and multi-state models. Statistics in Medicine, 26, 2389-2430.
25. Rosati, S., Mick, R., Xu, F., Stonys, E., Le Beau, M.M., Larson, R. & Vardiman, J.W. (1996) Refractory cytopenia with multilineage dysplasia: further characterization of an 'unclassifiable' myelodysplastic syndrome. Leukemia, 10, 20-26.
26. Runde, V., de Witte, T., Arnold, R., Gratwohl, A., Hermans, J., van Biezen, B.A., Niederwieser, D., Labopin, M., Walter-Noel, M.P., Bacigalupo, A., Jacobsen, N., Ljungman, P., Carreras, E., Kolb, H.J., Aul, C. & Apperley, J. (1998) Bone marrow transplantation from HLA-identical siblings as first-line treatment in patients with myelodysplastic syndromes: early transplantation is associated with improved outcome. Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplantation, 21, 255-261.
27. Sierra, J., Perez, W.S., Rozman, C., Carreras, E., Klein, J.P., Rizzo, J.D., Davies, S.M., Lazarus, H.M., Bredeson, C.N., Marks, D.I., Canals, C., Boogaerts, M.A., Goldman, J., Champlin, R.E., Keating, A., Weisdorf, D.J., de Witte, T.M. & Horowitz, M.M. (2002) Bone marrow transplantation from HLA-identical siblings as treatment for myelodysplasia. Blood, 100, 1997-2004.
28. Silverman, L.R., Demakos, E.P., Peterson, B.L., Kornblith, A.B., Holland, J.C., Odchimar-Reissig, R., Stone, R.M., Nelson, D., Powell, B.L., DeCastro, C.M., Ellerton, J., Larson, R.A., Schiffer, C.A. & Holland, J.F. (2002) Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. Journal of Clinical Oncology, 20, 2429-2440.
29. Sutton, L., Chastang, C., Ribaud, P., Jouet, J.P., Kuentz, M., Attal, M., Reiffers, J., Tigaud, J.M., Rio, B., Dauriac, C., Legros, M., Dreyfus, F., Lioure, B., Troussard, X., Milpied, N., Witz, F., Oriol, P., Cahn, J.Y., Michallet, M., Gluckman, E., Ifrah, N., Pico, J.L., Vilmer, E. & Leblond, V. (1996) Factors influencing outcome in de novo myelodysplastic syndromes treated by allogeneic bone marrow transplantation: a long-term study of 71 patients Societe Francaise de Greffe de Moelle. Blood, 88, 358-365.
30. Taussig, D.C., Davies, A.J., Cavenagh, J.D., Oakervee, H., Syndercombe-Court, D., Kelsey, S., Amess, J.A., Rohatiner, A.Z., Lister, T.A. & Barnett, M.J. (2003) Durable remissions of myelodysplastic syndrome and acute myeloid leukemia after reduced-intensity allografting. Journal of Clinical Oncology, 21, 3060-3065.
31. Vardiman, J.W., Harris, N.L. & Brunning, R.D. (2002) The World Health Organization (WHO) classification of the myeloid neoplasms. Blood, 100, 2292-2302.
32. de Witte, T., Hermans, J., Vossen, J., Bacigalupo, A., Meloni, G., Jacobsen, N., Ruutu, T., Ljungman, P., Gratwohl, A., Runde, V., Niederwieser, D., van Biezen, A., Devergie, A., Cornelissen, J., Jouet, J.P., Arnold, R. & Apperley, J. (2000) Haematopoietic stem cell transplantation for patients with myelo-dysplastic syndromes and secondary acute myeloid leukaemias: a report on behalf of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT). British Journal of Haematology, 110, 620-630.
33. de Witte, T., Suciu, S., Verhoef, G., Labar, B., Archimbaud, E., Aul, C., Selleslag, D., Ferrant, A., Wijermans, P., Mandelli, F., Amadori, S., Jehn, U., Muus, P., Boogaerts, M., Zittoun, R., Gratwohl, A., Zwierzina, H., Hagemeijer, A. & Willemze, R. (2001) Intensive chemotherapy followed by allogeneic or autologous stem cell transplantation for patients with myelodysplastic syndromes (MDSs) and acute myeloid leukemia following MDS. Blood, 98, 2326-2331.