Erythroid response to treatment with G-CSF plus erythropoietin for the anaemia of patients with myelodysplastic syndromes: Proposal for a predictive model

British Journal of Haematology

Volumn 99, Issue 2, 1997, Pages 344-351

  Hellström Lindberg, Eva ^a   Negrin, Robert ^b   Stein, Richard ^d   Krantz, Sanford ^d   Lindberg, Greger ^f   Vardiman, James ^e   Öst, Åke ^f   Greenberg, Peter ^b,c  

^a Department of Haematology ^*  (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cytokines; Erythropoiesis; Erythropoietin; G CSF; Myelodysplastic syndromes

Indexed keywords

CYTOKINE; ERYTHROPOIETIN; HEMOGLOBIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; AGED; ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ERYTHROCYTE TRANSFUSION; ERYTHROPOIESIS; FEMALE; FLU LIKE SYNDROME; HUMAN; MAJOR CLINICAL STUDY; MALE; MYELODYSPLASTIC SYNDROME; PATIENT SELECTION; PHASE 2 CLINICAL TRIAL; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROGNOSIS; REFRACTORY ANEMIA; SCORING SYSTEM; SKIN IRRITATION; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

EID: 0030682515     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.4013211.x     Document Type: Article

References (27)

1. Bennett, J.M., Catovsky, D., Daniel, M.T., Flandrin, G., Galton, D.A.G., Gralnick, H.R., Sultan, C., the French-American-British (FAB) group (1982) Proposals for the classification of the myelodysplastic syndromes. British Journal of Haematology, 51, 189-199.
2. Cazzola, M., Messinger, D., Battistel, V., Bron, D., Cimino, R., Enller-Ziegler, L., Essers, U., Greil, R., Grossi, A., Jäger, G., LeMevel, A., Najman, A., Silingardi, V., Spriano, M., van Hoof, A. & Ehmer, B. (1995) Recombinant human erythropoietin in the anemia associated with multiple myeloma or non-Hodgkin's lymphoma: dose finding and identification of predictors of response. Blood, 86, 4446-453.
3. Cazzola, M., Ponchio, L., Pedrotti, C., Farina, G., Cerani, P., Lucotti, C., Novella, A., Rovati, A., Bergamaschi, G. & Beguin, Y. (1996) Prediction of response to recombinant human erythropoietin (rHuEpo) in anaemia of malignancy. Haematologica, 81, 434-41.
4. Ganser, A., Maurer, A., Contzen, C., Seipelt, G., Ottmann, O.G., Schadeck-Gressel, C., Kolbe, K., Haas, R., Zander, C., Reutzel, R. & Hoelzer, D. (1996) Improved multilineage response of hematopoiesis in patients with myelodysplastic syndromes to a combination therapy with all-trans-retinoic acid, granulocyte colony-stimulating factor, erythropoietin and alpha-tocopherol. Annals of Hematology, 72, 237-44.
5. Greenberg, P.L. (1992) Treatment of myelodysplastic syndromes with haemopoietic growth factors. Seminars in Oncology, 19, 106-14.
6. Greenberg, P.L. (1994) The myelodysplastic syndromes. Hematology: Basic Principles and Practice, 2nd edn (ed. by R. Hoffman, E. Benz, S. Shattil, B. Furie and H. Cohen), pp. 1098-1121. Churchill Livingstone, New York.
7. Greenberg, P., Cox, C., LeBeau, M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., Ohyashiki, K., Toyama, K., Aul, C., Mufti, G. & Bennett, J. (1997) International prognostic scoring system for myelodysplastic syndromes. Blood, 89, in press.
8. Greenberg, P., Negrin, R. & Ginzton, N. (1992) In vitro-in vivo correlations of erythroid responses to G-CSF plus eryhtropoietin (epo) in myelodysplastic syndromes. (Abstract). (MDS). Experimental Hematology, 6, 733.
9. Greenberg, P., Taylor, K., Larson, R., Koeffler, P., Negrin, R., Saba, H., Ganser, A., Jakubowski, A., Gabrilove, J., Mufti, G., Cruz, J., Hammond, W., Broudy, V., Langley, G.R., Keating, A., Vardiman, J., Lamborn, K. & Brown, S. (1993) Phase III randomized multicenter trial of G-CSF vs observation for myelodysplastic syndromes (MDS). Blood, 82, (Suppl. 1), 196a.
10. Hogge, D.E., Cashman, J.D., Humphries, K. & Eaves, C. (1991) Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures. Blood, 77, 493-99.
11. Hellström-Lindberg, E. (1995) Efficacy of erythropoietin in the myelodysplastic syndromes: an analysis of 205 patients in 17 studies. British Journal of Haematology, 89, 67-71.
12. Hellström-Lindberg, E., Birgegård, G., Carlsson, M., Carneskog, J., Dahl, I.M., Dybedal, I., Grimfors, G., Merk, K., Tangen, J.M., Winqvist, I. & Öst, Å. (1993) A combination of granulocyte-colony-stimulating factor and erythropoietin may synergistically improve the anaemia in patients with myelodysplastic syndromes. Leukemia and Lymphoma, 11, 221-228.
13. Hellström-Lindberg, E., Kanter-Lewensohn, L. & Öst, Å. (1997) Morphological changes and apoptosis in bone marrow from patients treated with granulocyte-CSF and erythropoietin. Leukemia Research, in press.
14. Hellström-Lindberg, E., Robèrt, K.H., Gahrton, G., Forsblom, A.M., Lindberg, G., Kock, Y. & Öst, Å. (1992) A predictive model for the clinical response to low dose ara-C: a study of 102 patients with myelodysplastic syndromes or acute leukaemia. British Journal of Haematology, 81, 503-11.
15. Hellström-Lindberg, E., Tangen, J.M., Grimfors, G., Lindemalm, C., Carlsson, M., Öberg, G., Löwenberg, E., Linder, O., Dybedal, I., Dahl, I.M., Nilsson-Ehle, H., Ahlgren, T., Winquist, I., Carneskog, J., Luthman, M. & Öst, Å., for the Scandinavian MDS group (1996) Treatment of the anaemia in MDS with G-CSF and epo: final report from a rendomized study. Blood, 83, (Suppl. 1). abstract.
16. Imamura, M., Kobayashi, M., Kobayashi, S., Yoshida, K., Mikuni, C., Ishikawa, Y., Matsumoto, S., Sakamaki, S., Niitsu, Y., Hinoda, Y., Yachi, A., Kudoh, T., Chiba, S., Kasai, M., Oka, T., Okuno, A., Maekawa, I., Sakurada, K. & Miyazaki, T. (1994) Failure of combination therapy with granulocyte colony-stimulating factor and erythropoietin in myelodysplastic syndromes. Annals of Hematology, 68, 163-66.
17. Kerkhof, H., Hermans, J., Haak, H.L. & Leeksma, C.H.W. (1987) Utility of the FAB classification for myelodysplastic syndromes: investigation of prognostic factors in 237 patients. British Journal of Haematology, 65, 73-81.
18. Morel, P., Hebbar, M., Lai, J.L., Duhamel, A., Preudhomme, C., Wattel, E., Bauters, F. & Fenaux, P. (1993) Cytogenetic analysis has strong independent prognostic value in de novo myelodysplastic syndromes and can be incorporated in a new scoring system: a report on 408 cases. Leukemia, 7, 1315-1323.
19. Mufti, G.J., Stevens, J.R., Oscier, D.G., Hamblin, T.J. & Machin, D. (1985) Myelodysplastic syndromes: a scoring system with prognostic significance. British Journal of Haematology, 59, 425-433.
20. Musto, P., Falvone, A. & Carotenuto, M. (1994) Granulocyte colony-stimulating factor and erythropoietin for the anemia of myelodysplastic syndromes: a real improvement with respect to EPO alone? Blood, 84, 1687-1688.
21. Negrin, R.S., Nagler, A., Kobayashi, Y., Sklar, J., Donlon, T., Souza, L.M. & Greenberg, P.L. (1990) Maintenance treatment of patients with myelodysplastic syndromes using recombinant human granulocyte colony stimulating factor. Blood, 76, 36-43.
22. Negrin, R.S., Stein, R., Doherty, K., Cornwell, J., Vardiman, J., Krantz, S. & Greenberg, P. (1993) Treatment of the anemia of myelodysplastic syndromes using human granulocyte-CSF in combination with erythropoietin. Blood, 82, 737-743.
23. Negrin, R.S., Stein, R., Doherty, K., Cornwell, J., Vardiman, J., Krantz, S. & Greenberg, P. (1996) Maintenance treatment of the anemia of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor and erythropoietin: evidence for in vivo synergy. Blood, 87, 4076-4081.
24. Rose, E.H., Abels, R.I., Nelson, R.A., McCullough, D.M. & Lessin, L. (1995) The use of r-HUEpo in the treatment of anaemia related to myelodysplasia (MDS). British Journal of Haematology, 89, 831-837.
25. Sanz, G.F., Sanz, M.A., Vallespi, T., Cañizo, M.C., Torrabadella, M., García, S., Irriguible, D. & San Miguel, J.F. (1989) Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: a multivariate analysis of prognostic factors in 370 patients. Blood, 74, 395-408.
26. Spegelhalter, D. & Knill-Jones, R. (1984) Statistical and knowledge-based approaches to clinical decision support systems, with an application in gastroenterology. Journal of the Royal Statistical Society A, 147, 35-77.
27. Wide, L., Bengtsson, C. & Birgegård, G. (1989) Circadian rhythm of human serum erythropoietin. British Journal of Haematology, 51, 189-199.