Development of 5-HT transporter density and long-term effects of methylphenidate in an animal model of ADHD

World Journal of Biological Psychiatry

Volumn 10, Issue 4 PART 2, 2009, Pages 581-585

  Roessner, Veit ^a   Manzke, Till ^a   Becker, Andreas ^a   Rothenberger, Aribert ^a   Bock, Nathalie ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

ADHD; Methylphenidate; Serotonin transporter; Spontaneously hypertensive rat

Indexed keywords

METHYLPHENIDATE; SEROTONIN TRANSPORTER; CARRIER PROTEIN; CENTRAL STIMULANT AGENT; DRUG RECEPTOR; PAROXETINE; PAROXETINE RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SLC6A4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; AGE; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DOSE RESPONSE; MALE; METABOLISM; PATHOLOGY; WISTAR KYOTO RAT;

AGE FACTORS; ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CARRIER PROTEINS; CENTRAL NERVOUS SYSTEM STIMULANTS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; METHYLPHENIDATE; PAROXETINE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, DRUG; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS;

EID: 77449138792     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.1080/15622970802653709     Document Type: Article

References (22)

1. Adriani W, Caprioli A, Granstrem O, Carli M, Laviola G. 2003. The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopula-tions. Neurosci Biobehav Rev 27:639-651.
2. Albayrak O, Friedel S, Schimmelmann BG, Hinney A, Hebeb-rand J. 2008. Genetic aspects in attention-deficit/hyperactivity disorder. J Neural Transm 115:305-315.
3. Bizot JC, Chenault N, Houze B, Herpin A, David S, Pothion S, Trovero F. 2007. Methylphenidate reduces impulsive behaviour in juvenile Wistar rats, but not in adult Wistar, SHR and WKY rats. Psychopharmacology (Berlin) 193:215-223.
4. Bock N, Quentin DJ, Huther G, Moll GH, Banaschewski T, Rothenberger A. 2005. Very early treatment with fluoxetine and reboxetine causing long-lasting change of the serotonin but not the noradrenaline transporter in the frontal cortex of rats. World J Biol Psychiatry 6:107-112.
5. Bolanos CA, Barrot M, Berton O, Wallace-Black D, Nestler EJ. 2003. Methylphenidate treatment during pre-and periadoles-cence alters behavioral responses to emotional stimuli at adulthood. Biol Psychiatry 54:1317-1329.
6. Bolanos CA, Willey MD, Maffeo ML, Powers KD, Kinka DW, Grausam KB, Henderson RP. 2008. Antidepressant treatment can normalize adult behavioral deficits induced by early-life exposure to methylphenidate. Biol Psychiatry 63:309-316.
7. Carlezon WA Jr, Mague SD, Andersen SL. 2003. Enduring behavioral effects of early exposure to methylphenidate in rats. Biol Psychiatry 54:1330-1337.
8. Fox AT, Hand DJ, Reilly MP. 2008. Impulsive choice in a rodent model of attention-deficit/hyperactivity disorder. Behav Brain Res 187:146-152.
9. Grund T, Lehmann K, Bock N, Rothenberger A, Teuchert-Noodt G. 2006. Influence of methylphenidate on brain development-An update of recent animal experiments. Behav Brain Funct 2:2.
10. Kollins SH, March JS. 2007. Advances in the pharmacotherapy of attention-deficit/hyperactivity disorder. Biol Psychiatry 62:951-953.
11. Liu Y, Reichelt KL. 2001. A serotonin uptake-stimulating tetrapeptide found in urines from ADHD children. World J Biol Psychiatry 2:144-148.
12. Moll GH, Mehnert C, Wicker M, Bock N, Rothenberger A, Ruther E, Huether G. 2000. Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood. Brain Res Dev Brain Res 119:251-257.
13. Oades RD. 2007. Role of the serotonin system in ADHD: treatment implications. Expert Rev Neurother 7:1357-1374.
14. Oades RD, Slusarek M, Velling S, Bondy B. 2002. Serotonin platelet-transporter measures in childhood attention-deficit/hyperactivity disorder (ADHD): clinical versus experimental measures of impulsivity. World J Biol Psychiatry 3:96-100.
15. Pliszka SR. 2005. The neuropsychopharmacology of attention-deficit/ hyperactivity disorder. Biol Psychiatry 57:1385-1390.
16. Roessner V, Sagvolden T, Manzke T, Becker A, Rothenberger A, Bock N. 2008. d, 1-Methylphenidate normalizes elevated dopamine transporter density in an animal model of ADHD combined type, but not in one of ADHD inattentive type. submitted.
17. Schwarting RK, Thiel CM, Muller CP, Huston JP. 1998. Relationship between anxiety and serotonin in the ventral striatum. Neuroreport 9:1025-1029.
18. Soghomonian JJ, Doucet G, Descarries L. 1987. Serotonin innervation in adult rat neostriatum. I. Quantified regional distribution. Brain Res 425:85-100. (Pubitemid 17159372)
19. van den Bergh FS, Bloemarts E, Chan JS, Groenink L, Olivier B, Oosting RS. 2006. Spontaneously hypertensive rats do not predict symptoms of attention-deficit hyperactivity disorder. Pharmacol Biochem Behav 83:380-390.
20. Volkow ND, Insel TR. 2003. What are the long-term effects of methylphenidate treatment? Biol Psychiatry 54:1307-1309.
21. Winstanley CA, Eagle DM, Robbins TW 2006. Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies. Clin Psychol Rev 26:379-395.
22. Zhang K, Davids E, Tarazi FI, Baldessarini RJ. 2002. Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity. Brain Res Dev Brain Res 137:135-138.